Bth5.5

Betaine HCl Research

6 peer-reviewed studies · Evidence score: 5.5/10

Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption

Faber KP et al. • Pharmaceutical research (2017)

The co-administration of rabeprazole with atazanavir resulted in significant decreases in atazanavir exposure.

Pretreatment with rabeprazole resulted in significant reductions in atazanavir Cmax (p < 0.01) and AUC0-last (p < 0.001) (71 and 70%, respectively), and modest decreases in ritonavir Cmax and AUClast (p < 0.01) (40% and 41%, respectively).
The addition of betaine HCl restored 13% of ATV Cmax and 12% of AUClast lost due to rabeprazole.
The co-administration of rabeprazole with atazanavir resulted in significant decreases in atazanavir exposure.

RCTn=8

DOI

The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria

Yago MR et al. • The AAPS journal (2014)

Therefore, BHCl reversed the impact of hypochlorhydria on dasatinib drug exposure and may be an effective strategy to mitigate potential drug-drug interactions for drugs that exhibit pH-dependent solubility and are administered orally under hypochlorhydric conditions.

Rabeprazole (20 mg b.i.d.) significantly reduced dasatinib Cmax and AUC0-∞ by 92 and 78%, respectively.
However, coadministration of BHCl significantly increased dasatinib Cmax and AUC0-∞ by 15- and 6.7-fold, restoring them to 105 and 121%, respectively, of the control (dasatinib alone).
In this randomized, single-dose, three-way crossover study, healthy volunteers received dasatinib (100 mg) alone, after pretreatment with rabeprazole, and with 1500 mg BHCl after rabeprazole pretreatment, to determine if BHCl can enhance dasatinib absorption in hypochlorhydric conditions.

RCTn=25

DOI

Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria

Yago MR et al. • Molecular pharmaceutics (2013)

The rapid onset and relatively short duration of gastric pH reduction gives betaine HCl the potential to aid the absorption of orally administered weakly basic drugs that exhibit pH-dependent solubility when administered under hypochlorhydric conditions.

The reacidification period was temporary with a gastric pH < 3 and < 4 lasting 73 (± 33) and 77 (± 30) min, respectively.
Betaine HCl was well tolerated by all subjects.
In healthy volunteers with pharmacologically induced hypochlorhydria, betaine HCl was effective at temporarily lowering gastric pH.

RCT

DOI

Co-administration of methyl donors along with guanidinoacetic acid reduces the incidence of hyperhomocysteinaemia compared with guanidinoacetic acid administration alone

Ostojic SM et al. • The British journal of nutrition (2013)

The concomitant supplementation of methyl donors along with GAA largely precluded the elevation of serum homocysteine caused by GAA administration alone.

The proportion of participants who reported minor adverse events was 33.3 % in the GAA group, and 10.0 % in the GAA with methyl donors group (P= 0.30).
Hyperhomocysteinaemia was found in 55.6 % of participants supplemented with GAA, while no participant experienced hyperhomocysteinaemia in the group supplemented with GAA and methyl donors (P= 0.01).
In summary, both interventions strongly influenced creatine metabolism, resulting in a significant increase in fasting serum creatine.

RCT

DOI

Use of Betaine HCl with Pepsin in Esophageal Cancer Patient: A Case Report

Amidon S et al. • Journal of medicinal food (2024)

The success with BHClP for this patient case suggests that more research is needed to fully realize the mechanisms and clinical usage.

After a few months, the patient discontinued BHClP, and GI symptoms and dumping syndrome returned, leading to a loss of 7.5% of his body weight.
The patient reinitiated the supplement and GI symptoms dissipated, and weight was restored.
BHClP provided metabolic therapeutic benefit to optimize the patient's oral intake, preventing further complications and malnutrition.

Observational

DOI

In vitro hyperthermia with improved colloidal stability and enhanced SAR of magnetic core/shell nanostructures

Patil RM et al. • Materials science & engineering. C, Materials for biological applications (2016)

The cytotoxicity of core/shells done on L929 and HeLa cell lines using 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide and trypan blue dye exclusion assays showed >89% and >80% cell vi...

The cytotoxicity of core/shells done on L929 and HeLa cell lines using 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide and trypan blue dye exclusion assays showed >89% and >80% cell viability for 24 and 48h respectively.
About 95% cell death was occurred in 90min after hyperthermia treatment.
The mechanism of cell death was found to be elevated ROS generation in cells after exposure to core/shells in external magnetic field.

In Vitro

DOI

View in Research Library