1Meta-Analysis2026
Shao C, Lin H, Yu J, Chen H, Ren Y, Ren J · Diabetes Obes Metab (2026)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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25 peer-reviewed studies
What the evidence says
Bimagrumab doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality meta-analyses and randomised trials published 2014–2026.
Based on 25 studies · 3 meta-analyses · 15 RCTs
Confidence
High confidenceBy outcome
16 studies in the last 5 years · Latest meta-analysis: 2026
Shao C, Lin H, Yu J, Chen H, Ren Y, Ren J · Diabetes Obes Metab (2026)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Spitz RW, Dankel SJ, Bell ZW, Wong V, Abe T, Kang M · Geriatr Gerontol Int (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Santos EJF, Farisogullari B, Yapp N, Townsley H, Sousa P, Machado PM · RMD Open (2025)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: Bimagrumab plus semaglutide resulted in substantial reductions in body weight, and safety was consistent with the known safety profiles of both drugs.
Heymsfield SB, Aronne LJ, Montgomery P, Klickstein LB, Coleman LA, Dole K, Mindeholm L, Spruill S, Li X, Attie KM, BELIEVE trial investigators. · Nature medicine (2026)
Rooks D, Swan T, Goswami B, Filosa LA, Bunte O, Panchaud N · JAMA Netw Open (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Amato AA, Hanna MG, Machado PM, Badrising UA, Chinoy H, Benveniste O · Neurology (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Garito T, Zakaria M, Papanicolaou DA, Li Y, Pinot P, Petricoul O · Clin Endocrinol (Oxf) (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Hofbauer LC, Witvrouw R, Varga Z, Shiota N, Cremer M, Tanko LB · Lancet Healthy Longev (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Hanna MG, Badrising UA, Benveniste O, Lloyd TE, Needham M, Chinoy H · Lancet Neurol (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Rooks DS, Laurent D, Praestgaard J, Rasmussen S, Bartlett M, Tankó LB · J Cachexia Sarcopenia Muscle (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Amato AA, Sivakumar K, Goyal N, David WS, Salajegheh M, Praestgaard J · Neurology (2014)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Polkey MI, Praestgaard J, Berwick A, Franssen FME, Singh D, Steiner MC · Am J Respir Crit Care Med (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Petricoul O, Nazarian A, Schuehly U, Schramm U, David OJ, Laurent D · Clin Pharmacokinet (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Rooks D, Yates DP, Neelakantham S, Praestgaard J, Cury RC, Lamb HJ · J Clin Endocrinol Metab (2026)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Heymsfield SB, Coleman LA, Miller R, Rooks DS, Laurent D, Petricoul O · JAMA Netw Open (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Garito T, Roubenoff R, Hompesch M, Morrow L, Gomez K, Rooks D · Diabetes Obes Metab (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Rooks D, Praestgaard J, Hariry S, Laurent D, Petricoul O, Perry RG · J Am Geriatr Soc (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Rooks D, Petricoul O, Praestgaard J, Bartlett M, Laurent D, Roubenoff R · J Cachexia Sarcopenia Muscle (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: This narrative review discusses the justification for focus on lean mass preservation and reviews the status of relevant drugs in development.
Ryan DH. · Reviews in endocrine & metabolic disorders (2025)
In plain English: Pharmacological adjunct therapies show potential for improving body composition and physical function during GLP-1 RA-induced weight loss.
Aimelet V, Holst JJ. · Diabetes, obesity & metabolism (2026)