1Meta-Analysis2026
Shao C, Lin H, Yu J, Chen H, Ren Y, Ren J · Diabetes Obes Metab (2026)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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25 peer-reviewed studies
What the evidence says
Most Bimagrumab studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2014–2026 with a typical study size of 507 participants.
Based on 25 studies · 3 meta-analyses · 15 RCTs · 507 total participants
Confidence
High confidenceBy outcome
16 studies in the last 5 years · Latest meta-analysis: 2026
Shao C, Lin H, Yu J, Chen H, Ren Y, Ren J · Diabetes Obes Metab (2026)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Spitz RW, Dankel SJ, Bell ZW, Wong V, Abe T, Kang M · Geriatr Gerontol Int (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Santos EJF, Farisogullari B, Yapp N, Townsley H, Sousa P, Machado PM · RMD Open (2025)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Heymsfield SB, Aronne LJ, Montgomery P, Klickstein LB, Coleman LA, Dole K, Mindeholm L, Spruill S, Li X, Attie KM, BELIEVE trial investigators. · Nature medicine (2026)
Rooks D, Swan T, Goswami B, Filosa LA, Bunte O, Panchaud N · JAMA Netw Open (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Amato AA, Hanna MG, Machado PM, Badrising UA, Chinoy H, Benveniste O · Neurology (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Garito T, Zakaria M, Papanicolaou DA, Li Y, Pinot P, Petricoul O · Clin Endocrinol (Oxf) (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Hofbauer LC, Witvrouw R, Varga Z, Shiota N, Cremer M, Tanko LB · Lancet Healthy Longev (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Hanna MG, Badrising UA, Benveniste O, Lloyd TE, Needham M, Chinoy H · Lancet Neurol (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Rooks DS, Laurent D, Praestgaard J, Rasmussen S, Bartlett M, Tankó LB · J Cachexia Sarcopenia Muscle (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Amato AA, Sivakumar K, Goyal N, David WS, Salajegheh M, Praestgaard J · Neurology (2014)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Polkey MI, Praestgaard J, Berwick A, Franssen FME, Singh D, Steiner MC · Am J Respir Crit Care Med (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Petricoul O, Nazarian A, Schuehly U, Schramm U, David OJ, Laurent D · Clin Pharmacokinet (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Rooks D, Yates DP, Neelakantham S, Praestgaard J, Cury RC, Lamb HJ · J Clin Endocrinol Metab (2026)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Heymsfield SB, Coleman LA, Miller R, Rooks DS, Laurent D, Petricoul O · JAMA Netw Open (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Garito T, Roubenoff R, Hompesch M, Morrow L, Gomez K, Rooks D · Diabetes Obes Metab (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Rooks D, Praestgaard J, Hariry S, Laurent D, Petricoul O, Perry RG · J Am Geriatr Soc (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Rooks D, Petricoul O, Praestgaard J, Bartlett M, Laurent D, Roubenoff R · J Cachexia Sarcopenia Muscle (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: This narrative review discusses the justification for focus on lean mass preservation and reviews the status of relevant drugs in development.
Ryan DH. · Reviews in endocrine & metabolic disorders (2025)
In plain English: Preliminary findings are promising, but larger, controlled trials are necessary to confirm efficacy and safety before clinical implementation can be considered.
Aimelet V, Holst JJ. · Diabetes, obesity & metabolism (2026)