50 peer-reviewed studies · Evidence score: 8/10
Jafari A et al. • Pharmacological research (2025)
Our findings suggest that N. sativa could be a promising adjunct therapy for improving cardiovascular disease (CVD) risk factors.
Hosseini H et al. • Current pharmaceutical biotechnology (2024)
Our results showed that THE consumption of N. sativa could be associated with improved oxidative stress and inflammation in patients with metabolic syndrome and related disorders.
Shahinfar H et al. • Pharmacological research (2023)
We conducted random-effects network meta-analysis with a Frequentist framework to estimate mean difference [MD] and 95% confidence interval [CI] of the effect of nutraceuticals on weight loss.
Kavyani Z et al. • Inflammopharmacology (2023)
N. sativa supplementation had beneficial effects on CRP, TNF-α, MDA, SOD, GPx, and TAC.
Báez G et al. • The Cochrane database of systematic reviews (2023)
Based on moderate to very low-certainty evidence, we identified some herbal medicines that may be effective in improving symptoms of dyspepsia.
Gyawali D et al. • Medicina (Kaunas, Lithuania) (2021)
In addition, minimal evidence was found for any side effects associated with these herbs, positioning them as safe adjuvants to conventional treatments.
Ahmadian M et al. • Current drug discovery technologies (2022)
Whitania somnifera roots, Alpinia officinarum, Nigella sativa seeds, Tomato, and Ceratonia siliqua and the formulation of Xperm, PHF, Churna Ratnam, Svaguptadi Churna, Y virilin capsule, manix capsule, and Tradafertil tablet revealed successful outcomes in treatment of idiopathic male infertility.
Razmpoosh E et al. • Pharmacological research (2020)
Subgroup analysis showed that, an intervention of more than 12 weeks was found to have a reducing effect on aspartate- aminotransferase (AST) measures (2 trials, n = 201 participants, WMD= -11.317;...
Nordin A et al. • BMC complementary and alternative medicine (2019)
Through this review, Nigella sativa and thymoquinone have been associated with events in Type 2 EMT.
Javidi N et al. • Current drug discovery technologies (2023)
Some herbal remedies, including Nigella sativa L., ashwagandha, and Mentha x Piperita L., can improve the signs and symptoms of primary hypothyroidism, but using a more extensive and advanced methodology will provide us with more complete results.
Tang G et al. • Phytotherapy research : PTR (2021)
High-quality large sample RCTs are necessary to confirm the benefit of NS supplementation for NAFLD.
Li E et al. • BMC complementary medicine and therapies (2025)
Current evidence supports the use of ginger and turmeric for glycaemic control in type 2 diabetes, however, given the high clinical heterogeneity and low quality of the review, our confidence in this finding is somewhat limited.
Karimi M et al. • Complementary therapies in medicine (2025)
Black seed supplementation appears to significantly improve FBG, HbA1c, TC, and LDL levels in patients with T2DM.
Shirvani S et al. • Prostaglandins & other lipid mediators (2024)
Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as weighted mean differences with a 95 % confidence interval.
Malekian S et al. • Journal of complementary & integrative medicine (2021)
Thus, further studies are required to fully assess its impacts on all oxidative stress and inflammatory biomarkers.
Sahebkar A et al. • Pharmacological Research (2016)
Black seed improved multiple metabolic parameters.
Gandhi GR et al. • Critical reviews in food science and nutrition (2024)
In conclusion, dietary plant-derived essential oil compounds have potential anti-diabetic effects by influencing different signaling pathways and molecular targets linked to glucose metabolism, and should be safe and beneficial against diabetes and related complications.
Kow CS et al. • Phytotherapy research : PTR (2024)
This meta-analysis examined the effects of Black Seed Oil.
Osowiecka K et al. • Nutrients (2023)
Therefore, there is a great need for further experimental studies to determine whether any nutritional interventions are beneficial in Hashimoto's disease.
Elhariri S et al. • West African journal of medicine (2024)
Nigella Sativa has proved to have a significant positive effect on lipid profile and glycaemic index.