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Bso6.5
Black Seed Oil Research
Likely helps
169 peer-reviewed studies
What the evidence says
Likely helps
Black Seed Oil appears to help in 11 of 12 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2003–2026 with a typical study size of 358 participants.
Based on 169 studies · 52 meta-analyses · 68 RCTs · 35,460 total participants
Confidence
High confidence
What the studies found
11helped1unclear· 157 more without graded effect data
2Oxidative stress and inflammationMeta-AnalysisCited 1×n=1,033 · large study2024
Our results showed that THE consumption of N. sativa could be associated with improved oxidative stress and inflammation in patients with metabolic syndrome and related disorders.
Hosseini H et al. · Current pharmaceutical biotechnology (2024)
Huge benefit
← WorseNo effectBetter →
Likely real
In addition, SOD: (SMD: 1.35; (95% CI, from 0.77 to 1.93); P = 0.00) and TAC (SMD: 2.82; (95% CI, from 0.55 to 5.084); P = 0.01) levels significantly increased in the intervention group compared to the placebo group.
Our results showed that THE consumption of N. sativa could be associated with improved oxidative stress and inflammation in patients with metabolic syndrome and related disorders.
3Body weight reductionMeta-AnalysisCited 11×n=6,171 · very large study2023
We conducted random-effects network meta-analysis with a Frequentist framework to estimate mean difference [MD] and 95% confidence interval [CI] of the effect of nutraceuticals on weight loss.
Shahinfar H et al. · Pharmacological research (2023)
Noticeable benefit
← WorseNo effectBetter →
We conducted random-effects network meta-analysis with a Frequentist framework to estimate mean difference [MD] and 95% confidence interval [CI] of the effect of nutraceuticals on weight loss.
Supplementations with green tea (MD: -1.25 kg, 95%CI: -1.68, -0.82) and glucomannan (MD: -1.36 kg, 95%CI: -2.17, -0.54) demonstrated small weight loss, also the certainty of evidence was rated low.
Based on our findings, supplementations with nutraceuticals can result in a small weight loss in adults with overweight or obesity.
5Global symptoms of dyspepsiaSystematic ReviewCited 10×n=4,477 · very large study2023
Based on moderate to very low-certainty evidence, we identified some herbal medicines that may be effective in improving symptoms of dyspepsia.
Báez G et al. · The Cochrane database of systematic reviews (2023)
Noticeable benefit
← WorseNo effectBetter →
STW5 (Iberogast) may moderately improve global symptoms of dyspepsia compared with placebo at 28 to 56 days; however, the evidence is very uncertain (MD -2.64, 95% CI -4.39 to -0.90; I2 = 87%; 5 studies, 814 participants; very low CoE).
STW5 may also increase the improvement rate compared to placebo at four to eight weeks' follow-up (RR 1.55, 95% CI 0.98 to 2.47; 2 studies, 324 participants; low CoE).
There was little to no difference in adverse events for STW5 compared to placebo (RR 0.92, 95% CI 0.52 to 1.64; I2 = 0%; 4 studies, 786 participants; low CoE).
6Cholesterol levelsMeta-AnalysisCited 17×n=1,386 · large study2021
In addition, minimal evidence was found for any side effects associated with these herbs, positioning them as safe adjuvants to conventional treatments.
Gyawali D et al. · Medicina (Kaunas, Lithuania) (2021)
Noticeable benefit
← WorseNo effectBetter →
Likely real
Meta-analysis of the trials showed that guggulu reduced total cholesterol and low-density lipoprotein levels by 16.78 mg/dL (95% C.I. 13.96 to 2.61; p-value = 0.02) and 18.78 mg/dL (95% C.I. 34.07 to 3.48; p = 0.02), respectively.
Garlic reduced LDL-C by 10.37 mg/dL (95% C.I. -17.58 to -3.16; p-value = 0.005).
Black cumin lowered total cholesterol by 9.28 mg/dL (95% C.I. -17.36, to -1.19, p-value = 0.02).
7Idiopathic male infertility treatmentSystematic ReviewCited 3×n=1,218 · large study2022
Whitania somnifera roots, Alpinia officinarum, Nigella sativa seeds, Tomato, and Ceratonia siliqua and the formulation of Xperm, PHF, Churna Ratnam, Svaguptadi Churna, Y virilin capsule, manix capsule, and Tradafertil tablet revealed successful outcomes in treatment of idiopathic male infertility.
Ahmadian M et al. · Current drug discovery technologies (2022)
Whitania somnifera roots, Alpinia officinarum, Nigella sativa seeds, Tomato, and Ceratonia siliqua and the formulation of Xperm, PHF, Churna Ratnam, Svaguptadi Churna, Y virilin capsule, manix capsule, and Tradafertil tablet revealed successful outcomes in treatment of idiopathic male infertility.
8AST reductionMeta-AnalysisCited 25×n=1,295 · large study2020
Subgroup analysis showed that, an intervention of more than 12 weeks was found to have a reducing effect on aspartate- aminotransferase (AST) measures (2 trials, n = 201 participants, WMD= -11.317;...
Razmpoosh E et al. · Pharmacological research (2020)
Noticeable benefit
← WorseNo effectBetter →
Likely real
Subgroup analysis showed that, an intervention of more than 12 weeks was found to have a reducing effect on aspartate- aminotransferase (AST) measures (2 trials, n = 201 participants, WMD= -11.317; 95 % CI: -15.007, -7.626; P = 0.000; I2 = 0.0 %; P-heterogeneity = 0.977).
Creatinine levels increased significantly in studies that considered adjusted analysis based on covariates (3 trials, n = 152 participants, WMD = 0.070; 95 % CI: 0.027, 0.112 U/L; P = 0.001; I2 = 0.0 %; P-heterogeneity = 0.788).
Longer duration of intervention and normal daily dosages of N.S supplements led to significant reductions in ALP and AST concentrations, respectively, while higher daily dosages increased BUN levels.