Borage Oil Research

Oral evening primrose oil and borage oil for eczema.

In plain English: This Cochrane review of 27 trials concluded that oral borage oil and evening primrose oil lack effect on eczema, with improvement no better than placebo.

Bamford JT, Ray S, Musekiwa A, van Gool C, Humphreys R, Ernst E · Cochrane Database Syst Rev (2013)

Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis.

Rosenstein ED, Kushner LJ, Kramer N, Kazandjian G · Prostaglandins Leukot Essent Fatty Acids (2003)

[Treatment of atopic dermatitis with borage seed oil (Glandol)--a time series analytic study].

Bahmer FA, Schäfer J · Kinderarztl Prax (1992)

Essential fatty acids in breast milk of atopic mothers: comparison with non-atopic mothers, and effect of borage oil supplementation.

Thijs C, Houwelingen A, Poorterman I, Mordant A, van den Brandt P · Eur J Clin Nutr (2000)

Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema.

Henz BM, Jablonska S, van de Kerkhof PC, Stingl G, Blaszczyk M, Vandervalk PG · Br J Dermatol (1999)

Alteration of baroreflex control of forearm vascular resistance by dietary fatty acids.

Mills DE, Mah M, Ward RP, Morris BL, Floras JS · Am J Physiol (1990)

Is there a beneficial effect of gamma-linolenic acid supplementation on body fat in postmenopausal hypertensive women? A prospective randomized double-blind placebo-controlled trial.

da Costa Hime LFC, Carvalho Lopes CM, Roa CL, Zuchelo LTS, Baracat EC, de Andrade J · Menopause (2021)

Dietary fatty acid supplementation alters stress reactivity and performance in man.

Mills DE, Prkachin KM, Harvey KA, Ward RP · J Hum Hypertens (1989)

[Gamma-linolenic-acid-rich borage seed oil capsules in children with atopic dermatitis. A placebo-controlled double-blind study].

Borrek S, Hildebrandt A, Forster J · Klin Padiatr (1997)

The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers.

Miles EA, Banerjee T, Calder PC · Prostaglandins Leukot Essent Fatty Acids (2004)

Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma.

Ziboh VA, Naguwa S, Vang K, Wineinger J, Morrissey BM, Watnik M · Clin Dev Immunol (2004)

Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and ɣ-linolenic acid-containing botanical oils.

Sergeant S, Hallmark B, Mathias RA, Mustin TL, Ivester P, Bohannon ML · Am J Clin Nutr (2020)

Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial.

Takwale A, Tan E, Agarwal S, Barclay G, Ahmed I, Hotchkiss K · BMJ (2003)

Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants.

Demmelmair H, Feldl F, Horváth I, Niederland T, Ruszinkó V, Raederstorff D · Lipids (2001)

Treatment of rheumatoid arthritis with gammalinolenic acid.

Leventhal LJ, Boyce EG, Zurier RB · Ann Intern Med (1993)

Gamma-linolenic acid supplementation for prophylaxis of atopic dermatitis--a randomized controlled trial in infants at high familial risk.

van Gool CJ, Thijs C, Henquet CJ, van Houwelingen AC, Dagnelie PC, Schrander J · Am J Clin Nutr (2003)

Gamma-linolenate reduces weight regain in formerly obese humans.

Schirmer MA, Phinney SD · J Nutr (2007)

Herbal therapy for treating rheumatoid arthritis.

In plain English: This Cochrane review found moderate evidence that GLA-containing oils — including borage, evening primrose, and blackcurrant seed oil — afford some benefit in relieving rheumatoid arthritis symptoms.

Cameron M, Gagnier JJ, Chrubasik S · Cochrane Database Syst Rev (2011)

Effect of borage oil consumption on fatty acid metabolism, transepidermal water loss and skin parameters in elderly people.

In plain English: Two months of borage oil consumption produced a statistically significant ~11% reduction in transepidermal water loss, indicating improved skin-barrier function in elderly people.

Brosche T, Platt D · Arch Gerontol Geriatr (2000)