37 peer-reviewed studies · Evidence score: 7/10
Alamoudi A et al. • Orbit (Amsterdam, Netherlands) (2025)
Tranexamic acid, vessel-preserving surgical methods, and magnesium sulfate dressings are among the most effective strategies for minimizing ecchymosis and edema in eyelid and periocular surgery.
Pereira IC et al. • Clinical nutrition ESPEN (2023)
The general effect of bromelain supplementation on inflammation is inconsistent because of population heterogeneity, doses used, treatment duration, and parameters evaluated.
Gremmler L et al. • Anticancer research (2021)
On the basis of existing evidence, there is no clear therapeutic benefit of enzymes neither as supportive therapy nor as part of antineoplastic therapy.
De Freitas LR et al. • Journal of burn care & research : official publication of the American Burn Association (2025)
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Pereira IC et al. • Journal of medicinal food (2025)
In general, it was possible to observe that supplementation was able to reduce side effects of adjuvant hormone therapy and chemotherapy, such as mucosal dryness, arthralgia, and peripheral neuropathy induced by chemotherapy.
Alves Nobre T et al. • Natural product research (2025)
Bromelain reduced IL-1β, IL-6 and TNF-α secretion when immune cells were already stimulated in an overproduction condition by proinflammatory cytokines, generating a modulation in the inflammatory response through prostaglandins reduction and activation of a cascade reactions that trigger neutrophils and macrophages, in addition to accelerating the healing process.
Pereira IC et al. • Clinical nutrition ESPEN (2025)
Our research suggests that bromelain possesses both prophylactic and curative qualities in terms of liver damage, as supported by its ability to decrease enzyme levels, enhance liver structure, reduce oxidative stress markers, and regulate lipid metabolism.
Buso G et al. • VASA. Zeitschrift fur Gefasskrankheiten (2025)
Dedicated clinical studies are needed to clarify the efficacy and safety of a combination of these molecules in CVD management.
Mohammed JS et al. • The Journal of pharmacy and pharmacology (2025)
Bromelain supplementation is effective in improving glycemic and lipid indices in diabetes.
Atiyeh B et al. • Journal of burn care & research : official publication of the American Burn Association (2024)
Though available evidence is not entirely in favor of replacing the current surgical SOC with BBD, it certainly presents ED as a highly advantageous modality for the management of burn wounds.
Kansakar U et al. • Nutrients (2024)
Since then, bromelain has gained recognition in both traditional and modern medicine for its potential therapeutic effects.
Leelakanok N et al. • Nutrition and health (2023)
Major health risks were not reported during the treatment with bromelain.
Shoham Y et al. • International wound journal (2023)
International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.
de A C Almeida R et al. • International journal of oral and maxillofacial surgery (2019)
A meta-analysis was performed for the outcomes pain and trismus and was based on the inverse variance method for continuous outcomes, considering the mean difference (MD) and corresponding 95% conf...
H S Delgado A et al. • Scientific reports (2022)
This systematic-review examined the effects of Bromelain.
Ahmadian R et al. • Wounds : a compendium of clinical research and practice (2021)
Per the studies included in this review, medicinal plants can be recommended as promising adjuvant therapies to conventional wound care to accelerate wound healing in patients with DFUs.
Ribeiro JS et al. • Phytotherapy research : PTR (2020)
Therefore, the current literature does not support the use of natural agents as dental bleaching.
de Souza GM et al. • Phytotherapy research : PTR (2019)
The results suggest that the bromelain appears to be effective in the control of pain, edema, and trismus after lower third molar surgeries; however, further high-quality studies are needed to confirm this finding.
Knackstedt R et al. • Annals of plastic surgery (2020)
However, there was no effect demonstrated when evaluating topical arnica following blepharoplasty procedures.
Wu AW et al. • International forum of allergy & rhinology (2020)
Some alternative therapies show promise as potential treatments for sinusitis and rhinitis, mostly compared to placebo.