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Cmc2.5

Camu Camu Research

Mostly mechanism / observationalHigh safety

4 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Camu Camu studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from mixed-quality randomised trials published 2000–2021 with a typical study size of 20 participants.

Based on 4 studies · 1 RCT · 20 total participants

Confidence

Low

By outcome

InflammationA small RCT showed reduced hs-CRP, IL-6 and IL-8 — but only 20 subjects over 7 days · ~1 week (small-trial surrogate markers)
Too few graded studies1 study

Steady research

1 study in the last 5 years

200020102021

1RCTn=20 · very small study2008

Camu-camu juice significantly lowered oxidative-stress and inflammatory markers in smokers, while an equivalent dose of vitamin C did not.

Inoue T, Komoda H, Uchida T, Node K · J Cardiol (2008)

Randomized 7-day trial in 20 male smokers (camu-camu juice vs vitamin C tablets, both ~1050 mg vitamin C/day)
Camu camu significantly reduced urinary 8-OHdG, total ROS, hs-CRP, IL-6 and IL-8
The vitamin C tablet group showed no significant change in these markers

View source

2In Vitro2021

Camu-camu fruit extract reduced reactive oxygen species and inflammatory signaling and activated the Nrf2 antioxidant pathway in cultured human keratinocytes.

Do NQ, Zheng S, Park B, Nguyen QTN, Choi BR, Fang M, Kim M, Jeong J, Choi J, Yang SJ, Yi TH · Molecules (2021)

In-vitro study in high-glucose-stressed human keratinocytes (skin cells)
Extract reduced ROS and downregulated NF-κB, AP-1 and NFAT-linked inflammatory mediators
Activated Nrf2/NQO1 antioxidant defense

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3In Vitro2019

Camu-camu seed extracts showed high antioxidant capacity and reduced cisplatin-induced chromosomal damage in vitro.

Carmo MAVD, Fidelis M, Pressete CG, Marques MJ, Castro-Gamero AM, Myoda T, Granato D, Azevedo L · Food Res Int (2019)

In-vitro characterization of camu-camu seed extracts
High total phenolic content and antioxidant capacity (DPPH, FRAP)
Reduced cisplatin-induced chromosomal breaks by ~37% (antimutagenic signal)

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4In Vitro2000

Camu-camu pulp is one of the richest known sources of vitamin C, containing roughly 1.2-3.0 g per 100 g.

Justi KC, Visentainer JV, Evelázio de Souza N, Matsushita M · Arch Latinoam Nutr (2000)

Compositional analysis of camu-camu pulp
Confirmed exceptionally high vitamin C content (~1.2-3.0 g/100 g)
Documented vitamin C losses (~26%) over prolonged frozen storage

View in Research Library

Camu Camu Research

Mostly mechanism / observational

Tropical fruit camu-camu (Myrciaria dubia) has anti-oxidative and anti-inflammatory properties.

Camu-Camu Fruit Extract Inhibits Oxidative Stress and Inflammatory Responses by Regulating NFAT and Nrf2 Signaling Pathways in High Glucose-Induced Human Keratinocytes.

Hydroalcoholic Myrciaria dubia (camu-camu) seed extracts prevent chromosome damage and act as antioxidant and cytotoxic agents.

Nutritional composition and vitamin C stability in stored camu-camu (Myrciaria dubia) pulp.