We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies

Can4.0

Canakinumab Research

Mostly mechanism / observational

123 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Canakinumab studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from high-quality meta-analyses and randomised trials published 2008–2026 with a typical study size of 355 participants.

Based on 122 studies · 24 meta-analyses · 64 RCTs · 4,386 total participants

Confidence

High confidence

By outcome

Inflammation & inflammagingDose-dependently reduced hsCRP and IL-6 with no effect on lipids — a clean test of the inflammation hypothesis · Weeks
Mostly mechanism / observational30 studies
Cardiovascular (CANTOS)CANTOS showed the 150 mg dose reduced recurrent cardiovascular events in post-MI patients, independent of any lipid change · Months to years
Mostly mechanism / observational16 studies
Cancer & periodic fever syndromes
Mostly mechanism / observational16 studies
Aging & healthspan (hypothesis)
Too few graded studies2 studies
Safety profile
Too few graded studies1 study

Active research area

55 studies in the last 5 years · Latest meta-analysis: 2026

200820172026

1Meta-Analysis2020

Kuemmerle-Deschner JB, Gautam R, George AT, Raza S, Lomax KG, Hur P · RMD Open (2020)

Canakinumab Research

Mostly mechanism / observational

Systematic literature review of efficacy/effectiveness and safety of current therapies for the treatment of cryopyrin-associated periodic syndrome, hyperimmunoglobulin D syndrome and tumour necrosis factor receptor-associated periodic syndrome.

Efficacy and safety of biological agents for systemic juvenile idiopathic arthritis: a systematic review and meta-analysis of randomized trials.

Systematic Review and Metaanalysis of Pharmacological Interventions in Adult-Onset Still Disease and the Role of Biologic Disease-Modifying Antirheumatic Drugs.

Comparative Effectiveness of Anti-Inflammatory Drug Treatments in Coronary Heart Disease Patients: A Systematic Review and Network Meta-Analysis.

Effect of anti-inflammatory therapy on major cardiovascular events in patients with diabetes: A meta-analysis.

Comparison of the efficacy and safety of biological agents in patients with systemic juvenile idiopathic arthritis: A Bayesian network meta-analysis of randomized controlled trials.

Early intensification versus step-up biologic strategies in systemic juvenile idiopathic arthritis: a Bayesian network meta-analysis of remission and safety outcomes.

Interleukin-1 inhibitors for acute gout.

Efficacy of biological agents in juvenile idiopathic arthritis: a systematic review using indirect comparisons.

The effect of canakinumab on clinical outcomes in patients with COVID-19: A meta-analysis.

A Systematic Review and Meta-Analysis of Injection Site Reactions in Randomized-Controlled Trials of Biologic Injections.

Effect of canakinumab on clinical and biochemical parameters in acute gouty arthritis: a meta-analysis.

A systematic literature review of efficacy, effectiveness and safety of biologic therapies for treatment of familial Mediterranean fever.

Efficacy and Safety of Pharmacologic Interventions in Patients Experiencing a Gout Flare: A Systematic Review and Network Meta-Analysis.

Interleukin-receptor antagonist and tumour necrosis factor inhibitors for the primary and secondary prevention of atherosclerotic cardiovascular diseases.

The benefit-risk balance for biological agents in juvenile idiopathic arthritis: a meta-analysis of randomized clinical trials.

Emerging biological therapies for treating chronic obstructive pulmonary disease: A pairwise and network meta-analysis.

Efficacy and safety of anti-interleukin-1 treatment in familial Mediterranean fever patients: a systematic review and meta-analysis.

A signaling pathway-driven bioinformatics pipeline for predicting therapeutics against emerging infectious diseases.

Impacts of pro-inflammatory cytokines variant on cardiometabolic profile and premature coronary artery disease: A systematic review and meta-analysis.