1Meta-Analysis2012
Irving G, Backonja M, Rauck R, Webster LR, Tobias JK, Vanhove GF · Clin J Pain (2012)
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183 peer-reviewed studies
What the evidence says
Most Capsaicin studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1990–2026 with a typical study size of 24 participants.
Based on 183 studies · 23 meta-analyses · 146 RCTs · 861 total participants
Confidence
High confidenceBy outcome
30 studies in the last 5 years · Latest meta-analysis: 2026
Irving G, Backonja M, Rauck R, Webster LR, Tobias JK, Vanhove GF · Clin J Pain (2012)
Whiting S, Derbyshire EJ, Tiwari B · Appetite (2014)
Zhang WY, Li Wan Po A · Eur J Clin Pharmacol (1994)
Zhang W, Zhang Q, Wang L, Zhou Q, Wang P, Qing Y · Br J Nutr (2023)
Irandoost P, Lotfi Yagin N, Namazi N, Keshtkar A, Farsi F, Mesri Alamdari N · Phytother Res (2021)
Zsiborás C, Mátics R, Hegyi P, Balaskó M, Pétervári E, Szabó I · Crit Rev Food Sci Nutr (2018)
Mason L, Moore RA, Derry S, Edwards JE, McQuay HJ · BMJ (2004)
Pourmand A, Esmailian G, Mazer-Amirshahi M, Lee-Park O, Tran QK · Am J Emerg Med (2021)
Persson MSM, Stocks J, Walsh DA, Doherty M, Zhang W · Osteoarthritis Cartilage (2018)
Foshati S, Moradi S, Tavassoly M, Rouhani MH · Food Funct (2021)
Mou J, Paillard F, Turnbull B, Trudeau J, Stoker M, Katz NP · Pain (2013)
van Nooten F, Treur M, Pantiri K, Stoker M, Charokopou M · Clin Ther (2017)
de Sèze M, Wiart L, Ferrière J, de Sèze MP, Joseph P, Barat M · Eur Urol (1999)
Grgic J, Memon AR, Chen S, Ramirez-Campillo R, Barreto G, Haugen ME · Nutrients (2022)
Ludy MJ, Moore GE, Mattes RD · Chem Senses (2012)
Griebeler ML, Morey-Vargas OL, Brito JP, Tsapas A, Wang Z, Carranza Leon BG · Ann Intern Med (2014)
Mou J, Paillard F, Turnbull B, Trudeau J, Stoker M, Katz NP · Clin J Pain (2014)
Whiting S, Derbyshire E, Tiwari BK · Appetite (2012)
Sabbineni M, Scott W, Punia K, Manuja K, Singh A, Campbell K · Acad Emerg Med (2024)
Goodwin B, Mitchell J, Major E, Podwojniak A, Brancaccio H, Rusinak K · Pain Manag (2024)