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Cpt3.5

Captopril Research

Mostly mechanism / observational

715 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Captopril studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from high-quality meta-analyses and randomised trials published 1979–2026 with a typical study size of 88 participants.

Based on 715 studies · 1 meta-analysis · 706 RCTs · 2,872 total participants

Confidence

High confidence

By outcome

Cardiovascular & renalReduces mortality and morbidity in heart failure and after myocardial infarction (human RCTs) · Months to years
Mostly mechanism / observational508 studies
Safety profile
Mostly mechanism / observational13 studies
Lifespan & aging (model organisms)
Mostly mechanism / observational10 studies

Slowing down

Only 14 studies in the last 5 years · Latest meta-analysis: 2002

197920022026

1Meta-Analysis2002

Simko F, Simková M, Kovacs L · Ceska Slov Farm (2002)

2RCT1983

Andrén L, Svensson A, Hansson L · Acta Med Scand Suppl (1983)

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3RCT1985

Bernini G, Taddei S, Graziadei L, Pedrinelli R, Salvetti A · J Hypertens Suppl (1985)

4RCT1994

Creager MA, Roddy MA · Hypertension (1994)

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5RCT1993

Lewis EJ, Hunsicker LG, Bain RP, Rohde RD · N Engl J Med (1993)

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6RCT1992

Franco RJ, Sampaio M, Balbi AL, Martin LC, Luna RL · Arq Bras Cardiol (1992)

7RCT1992

Lacourcière Y, Poirier L, Provencher P · J Hum Hypertens (1992)

8RCT1992

Paterna S, di Pasquale P, Martino S, Arrostuto A, Ingurgio NC, Parrinello G · Clin Ter (1992)

9RCT1988

Birkebaek NH, Vejby-Christensen H, Jakobsen P, Winther K · J Hypertens Suppl (1988)

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10RCT1994

Søgaard P, Nøgaard A, Gøtzsche CO, Ravkilde J, Thygesen K · Am Heart J (1994)

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11RCT1994

Skoularigis J, Eitzman L, Davis J, Strugo V, Sareli P · Am J Hypertens (1994)

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12RCT1993

Galcera-Tomas J, Nuño de la Rosa JA, Torres-Martinez G, Rodriguez-Garcia P, Castillo-Soria FJ, Canton-Martinez A · Eur Heart J (1993)

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13RCT1993

Van Mieghem W, Van Hedent T, Byttebier G · Acta Cardiol (1993)

14RCT1988

Sharpe N, Murphy J, Smith H, Hannan S · Lancet (1988)

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15RCT1980

Man in 't Veld AJ, Schicht IM, Derkx FH, de Bruyn JH, Schalekamp MA · Br Med J (1980)

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16RCT1989

Mammarella A, Paoletti V, Barlattani M, Leone G, Filippello CP, Mariani AR · Clin Ter (1989)

17RCT1992

Roberts DH, Tsao Y, Linge K, McLoughlin GA, Breckenridge A · Angiology (1992)

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18RCT1990

Di Pasquale P, Barone G, Paterna S, Cannizzaro S, Giubilato A · Drugs Exp Clin Res (1990)

19RCT1996

Budaj A, Cybulski J, Cedro K, Karczmarewicz S, Maciejewicz J, Wiśniewski M · Eur Heart J (1996)

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20RCT1995

Steffensen R, Grande P, Madsen JK, Rasmussen S, Haunsø S · Cardiology (1995)

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View in Research Library

Captopril Research

Mostly mechanism / observational

[The ACE inhibitor, captopril, in the light of new clinical studies].

Captopril or atenolol in essential hypertension.

Naloxone does not modify the antihypertensive effect of captopril in essential hypertensive patients.

Effect of captopril and enalapril on endothelial function in hypertensive patients.

The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.

[An open comparative study of captopril + hydrochlorothiazide versus chlorthalidone for the treatment of mild and moderate primary hypertension].

Comparison of the effects of amlodipine and captopril on clinic and ambulatory blood pressure.

[Captopril versus placebo in the prevention of hemicrania without aura. A randomized double-blind study].

The effect of nifedipine and captopril on platelet activation and prostanoid production in essential hypertension.

Therapeutic effects of captopril on ischemia and dysfunction of the left ventricle after Q-wave and non-Q-wave myocardial infarction.

Nifedipine versus captopril in the management of moderate hypertension in black patients.

Effects of early use of captopril on haemodynamics and short-term ventricular remodelling in acute anterior myocardial infarction.

Acute haemodynamic effects of lisinopril and captopril in patients with severe congestive heart failure.

Treatment of patients with symptomless left ventricular dysfunction after myocardial infarction.

Effects of an angiotensin-converting enzyme inhibitor (captopril) on blood pressure in anephric subjects.

[Efficacy and tolerability of captopril-hydrochlorothiazide vs amiloride-hydrochlorothiazide combination in mild to moderate arterial hypertension].

Double-blind comparison of captopril with nifedipine in hypertension complicated by intermittent claudication.

Efficacy of captopril before thrombolysis in acute myocardial infarction: preliminary findings.

Effects of captopril on ventricular arrhythmias in the early and late phase of suspected acute myocardial infarction. Randomized, placebo-controlled substudy of ISIS-4.

Short-term effects of captopril on exercise tolerance in patients with chronic stable angina pectoris and normal left ventricular function.