42 peer-reviewed studies · Evidence score: 7.5/10
Smith AE et al. • Journal of the International Society of Sports Nutrition (2025)
Fragmented dosing protocols of 4-6.4g/day over 5-8 weeks optimize strength and power outcomes.
Siafis S et al. • Molecular autism (2022)
Some medications could improve core symptoms, although this could be likely secondary to the improvement of associated symptoms.
Li N et al. • BMC endocrine disorders (2025)
Carnosine and β-alanine supplementation show potential as adjunct therapies for improving FBG, HbA1c and HOMA-β in prediabetes and T2DM.
Hadi F et al. • BMC pharmacology & toxicology (2021)
Augmentation of glutamatergic medications with SSRIs are beneficial in obsessive-compulsive patients, no harmful significant differences in any safety outcome were found between the groups.
Saunders B et al. • British journal of sports medicine (2017)
β-alanine had a significant overall effect while subgroup analyses revealed a number of modifying factors.
Georgiou GD et al. • International journal of sport nutrition and exercise metabolism (2024)
This may be used to inform further research, and professional or recreational training design, and optimization of supplementation strategies.
Saadati S et al. • Nutrition reviews (2024)
Carnosine/HCD supplementation may reduce inflammatory and oxidative stress biomarkers, and potentially modulate the cardiometabolic risks associated with chronic low-grade inflammation and lipid peroxidation.
Gilsanz L et al. • Critical reviews in food science and nutrition (2023)
According to the results of the studies reviewed, we would recommend β-A and SB co-supplementation during high intensity exercises lasting between 30 s and 10 min.
Abraham DA et al. • Amino acids (2021)
Further studies are warranted to know the effect of L-Carnosine for ASD management.
Mahmoud A et al. • Nutrients (2022)
However, the evidence is still scarce, and larger trials are needed to confirm or refute our findings.
Frediani JK et al. • Pain practice : the official journal of World Institute of Pain (2024)
Based on the review, we cannot recommend any supplement use for the management of CIPN, although further research into N-acetyl-cysteine, l-carnosine, crocin, and magnesium is warranted.
Fernández-Lázaro D et al. • Nutrients (2023)
Finally, there was a non-significant (p > 0.05) improvement in the anthropometric parameters of lean mass and fat mass. β-alanine supplementation appears to be safe and could be a suitable nutritional ergogenic aid for combat athletes.
Bell SM et al. • Nutrition reviews (2024)
HCD, supplementation improved scores on the Delayed recall examination, a neuropsychological test affected early in Alzheimer's disease.
Sureshkumar K et al. • Frontiers in bioscience (Landmark edition) (2023)
Clinical studies were conducted to manage chemotherapy induced toxicities and there are no clinical studies available for its anti-cancer use, and the current evidence does not support its use in the treatment of cardiovascular disease.
Dubois VD et al. • The Cochrane database of systematic reviews (2017)
There is currently no convincing evidence that NAC reverses cataract, nor prevents progression of cataract (defined as a change in cataract appearance either for the better or for the worse).
Baumert P et al. • Journal of cachexia, sarcopenia and muscle (2024)
Understanding the mechanisms that regulate skeletal muscle mass will help in developing effective treatments for muscle weakness.
Mehta O et al. • The journal of pain (2023)
PERSPECTIVE: Foreseeing the global burden of knee pain in Osteoarthritis (OA) and adverse effects of current pharmacological therapies, this study is envisaged to investigate serum metabolites and ...
Peng W et al. • Complementary therapies in medicine (2020)
Carnosine supplementation results in a decrease in HbA1C, but elicits no effect on HOMA-IR, Cholesterol, fasting blood sugar, TG and HDL-C.
Hobson RM et al. • Amino acids (2012)
The median effect of β-alanine supplementation is a 2.85% (-0.37 to 10.49%) improvement in the outcome of an exercise measure, when a median total of 179 g of β-alanine is supplemented.
Matthews JJ et al. • Advances in nutrition (Bethesda, Md.) (2021)
Inferences were made on posterior samples generated by Hamiltonian Markov Chain Monte Carlo using 90% credible intervals (90% CrI) and calculated probabilities.