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Cbd5.8
CBD Research
Mostly mechanism / observational
456 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most CBD studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1979–2026 with a typical study size of 63 participants.
Based on 456 studies · 57 meta-analyses · 249 RCTs · 60,446 total participants
Confidence
High confidence
By outcome
Therapeutic & clinical
Mostly mechanism / observational67 studies
Anxiety & stressMay reduce anxiety; evidence is promising but limited and lower-quality (not a substitute for proven treatments) · Acute-4 weeks
Mostly mechanism / observational30 studies
Cognitive function
Mostly mechanism / observational17 studies
Pain & analgesia
Mostly mechanism / observational17 studies
Safety profile
Mostly mechanism / observational16 studies
Sleep & insomniaWidely used for sleep, but a controlled trial found low-dose CBD no better than placebo on sleep metrics · Acute
Mostly mechanism / observational13 studies
Heart & blood pressure
Mostly mechanism / observational8 studies
Recovery
Mostly mechanism / observational6 studies
15 more outcomes with fewer studies not shown.
Active research area
313 studies in the last 5 years · Latest meta-analysis: 2026
197920022026
1Meta-Analysisn=2,949 · very large study2026
In plain English: However, the evidence certainty was low to very low, and these findings should be considered exploratory.
Kleiner D et al. · Medical sciences (Basel, Switzerland) (2026)
Data were combined into a common denominator and examined using a random-effects model with meta-regression expressed as mean difference (MD) and a 95% confidence interval (CI).
Significant improvements in spasm quality (MD = -16.87; 95% CI = (-29.75)-(-3.99)), bladder function (MD = -16.38; 95% CI = (-22.18)-(-10.58)), sleep disruption (MD = -15.75; 95% CI = (-22.02)-(-9.49)) and gait function (timed walk MD(s) = -5.31; 95% CI(s) = (-9.88)-(-0.74)) were observed.
The subject global impression of change (SGIC) improved significantly after the first month (odds ratio (OR) = 1.69; 95% CI = (1.30)-(2.18)).