We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies

Cph2.5

Centrophenoxine Research

Mostly mechanism / observational

5 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Centrophenoxine studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from medium-quality randomised trials published 1977–2008 with a typical study size of 50 participants.

Based on 5 studies · 3 RCTs · 50 total participants

Confidence

Moderate confidence

By outcome

Cognitive functionPossible modest memory-consolidation benefit — based on small, decades-old double-blind studies · Weeks (uncertain)
Mostly mechanism / observational4 studies

Older research base

Newest study from 2008

197719922008

1RCT2008

Zou JJ, Ji HJ, Wu DW, Yao J, Hu Q, Xiao DW · Clin Ther (2008)

View source

2RCTn=50 · small study1989

In plain English: 48% of the centrophenoxine group displayed improvements in memory functions against 28% of the placebo group.

Pek G, Fulop T, Zs-Nagy I. · Arch Gerontol Geriatr (1989)

Double-blind randomized trial in 50 nursing-home residents over 60 with mid-level dementia
Centrophenoxine 2 g/day for 8 weeks after a 2-week placebo run-in
Memory improvement in 48% of the verum group vs 28% of placebo (semi-quantitative, intra-individual comparison)

View source

3Review1989

In plain English: Changes in neuronal lipopigment have been reported with chronic administration of agents including centrophenoxine, which might protect neuronal function.

Dowson JH. · Br J Psychiatry (1989)

Review of neuronal lipopigment (lipofuscin) as a marker of cognitive impairment and aging
Notes centrophenoxine among agents reported to alter neuronal lipopigment
Frames the lipofuscin-clearance rationale as hypothesis warranting long-term study

View source

4RCT1977

In plain English: Meclofenoxate appears to increase the consolidation of new information into long-term memory, but does not affect other aspects of remembering.

Marcer D, Hopkins SM. · Age Ageing (1977)

Double-blind study in fit, able elderly subjects
Improved consolidation of new information into long-term memory
Significantly more subjects on meclofenoxate reported increased mental alertness

View source

5Animal1992

In plain English: The learning- and memory-facilitating effects of CDP-choline were similar to those of meclofenoxate and piracetam.

Petkov VD, Mosharrof AH, Kehayov R, et al. · Methods Find Exp Clin Pharmacol (1992)

Rodent learning/memory study comparing CDP-choline with meclofenoxate and piracetam
Meclofenoxate improved learning and memory in several avoidance and maze paradigms
Preclinical (rats/mice) — supports mechanism, not human efficacy

View in Research Library

Centrophenoxine Research

Mostly mechanism / observational

Bioequivalence and pharmacokinetic comparison of a single 200-mg dose of meclofenoxate hydrochloride capsule and tablet formulations in healthy Chinese adult male volunteers: a randomized sequence, open-label, two-period crossover study.

Gerontopsychological studies using NAI ('Nurnberger Alters-Inventar') on patients with organic psychosyndrome (DSM III, Category 1) treated with centrophenoxine in a double blind, comparative, randomized clinical trial.

Neuronal lipopigment: a marker for cognitive impairment and long-term effects of psychotropic drugs.

The differential effects of meclofenoxate on memory loss in the elderly.

Effect of CDP-choline on learning and memory processes in rodents.