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Ce5.0
Ceramides – Forschung
Überwiegend Mechanismus / Beobachtung
21 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Ceramides sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2011–2026 mit einer typischen Studiengröße von 60 Teilnehmenden.
Basierend auf 21 Studien · 1 Meta-Analyse · 11 RCTs · 285 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Was die Studien gefunden haben
2geholfen· 19 weitere ohne bewertete Effektdaten
Nach Outcome
Skin healthKleine RCTs zeigen eine verbesserte Hautfeuchtigkeit; erste Signale für Faltenreduktion/Elastizität · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung12 Studien
Depression & mood
Überwiegend Mechanismus / Beobachtung4 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung3 Studien
Glucose & metabolic
Zu wenige bewertete Studien2 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 11 Studien mit messbaren Effekten gezogen
Untersuchte Personen
285
typische Studie: 60 Personen
Stärkste Designs
12
1 gepoolt, 11 randomisiert
Zeigte Nutzen
100%
2/2 Studien
Wie lange Studien liefen
1–3 Monate
3
3+ Monate
1
Untersuchte Populationen
General population1
adults with dry skin1
Individuals with sphingolipid metabolism variations1
Patients with obesity and insulin resistance1
Aktives Forschungsgebiet
14 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2020
201120182026
1structural profiles and biological activities of sphingolipidsÜbersicht2026
10Emotional well-being and psychiatric disordersÜbersicht2026
Einfach gesagt: Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.
Kalinichenko LS et al. · Journal of neurochemistry (2026)
Multiple studies show the contribution of SLs to normal brain functioning and corresponding beneficial behavioral phenotypes, such as stress resilience, cognitive performance, and social interactions, which determine emotional well-being.
On the other hand, an imbalance in SL metabolism affects normal functioning of cells and thus contributes to the development of several psychiatric disorders, such as depression, anxiety, cognitive decline, schizophrenia, and others.
SLs are suggested as a potentially new mechanism of the key behavioral manifestations of emotional well-being, which might be further investigated as new biomarkers of life quality as well as physical and mental resilience.
Einfach gesagt: Nutritional strategies targeting ceramide metabolism represent a promising approach to improve metabolic health.
Arias-Marroquín AT et al. · Clinical nutrition ESPEN (2026)
Nutritional strategies targeting ceramide metabolism represent a promising approach to improve metabolic health.
Beyond their therapeutic potential, ceramides also emerge as dynamic lipidomic biomarkers capable of reflecting early metabolic changes and monitoring the efficacy of nutritional interventions.
Einfach gesagt: This article reviews the relationships between ceramides and disease pathogenesis, with a focus on dietary intervention as a viable strategy for lowering the concentration of circulating ceramides.
Wang S et al. · Journal of lipid research (2025)
Mechanistic insights into these interventions are discussed.
This article reviews the relationships between ceramides and disease pathogenesis, with a focus on dietary intervention as a viable strategy for lowering the concentration of circulating ceramides.
Einfach gesagt: Targeting sphingolipid metabolism through nutritional or pharmacological strategies may offer novel opportunities for preventing and managing diet-associated cardiac dysfunction.
Basilicata MG, Scisciola L, Capone F, Trevellin E, Paolisso P, Belmonte M, Marfella LV, Zanzillo M, Sabbatino L, De Rosa L, Celardo N, Acunto M, Pesapane A, Fontanella RA, Balzano N, Lettera N, Palazzo AMM, Tortorella G, Joshi R, Zia A, Ulfat Z, Arshad M, Fioretto P, Paolisso G, Barbieri M. · Nutrients (2026)
Lipidomic studies highlight species-specific effects, with C16-ceramides frequently associated with adverse metabolic and cardiovascular outcomes, whereas very-long-chain ceramides may exert distinct functional roles.
Circulating ceramide profiles have also been linked to diet-associated cardiovascular risk.
Conclusions: Diet-induced ceramide remodeling represents a central molecular axis connecting dietary lipid excess to altered cardiac metabolic signaling.
Einfach gesagt: While some evidence is promising, the reliability of these products, as well as their optimal dosage and frequency, remains uncertain.
Cespedes Zablah A et al. · Dermatitis : contact, atopic, occupational, drug (2026)
Oral ceramides, blackcurrant seed oil, and hempseed oil have yet to be thoroughly studied, but preliminary results are promising.
Among the studies, the supplementation doses and duration of treatment varied extensively.
The literature did not provide comparative analysis between the supplements, and data on the overall safety and tolerability of these supplements are limited.
16Skin aging (wrinkles, hydration, elasticity)RCTn=63 · small study2025
Einfach gesagt: The intervention group exhibited significant increases in skin hydration and elasticity in the leg region relative to the placebo group.
Grier-Welch AM et al. · Dermatology and Therapy (Heidelberg) (2025)
63 participants randomized to an oral supplement of wheat oil extract plus low-molecular-weight sodium hyaluronate or placebo for 12 weeks
Significant reduction in crow's-feet wrinkles and improved facial and global smoothness from week 8 onward vs placebo
Significant increases in leg-region skin hydration and elasticity vs placebo
Einfach gesagt: Skin hydration was significantly increased between D0 and D84 on the arms (P < 0.001) and legs (P = 0.012) in the WEO group compared with placebo.
Guillou S et al. · International Journal of Cosmetic Science (2011)
51 women aged 20-63 with dry to very dry skin received either 350 mg/day wheat extract oil (rich in ceramides) or placebo for 3 months
Skin hydration significantly increased on arms (P<0.001) and legs (P=0.012) vs placebo
Skin dryness and redness tended to be reduced; WEO capsules well tolerated
Einfach gesagt: The barrier function improving effect of plant-derived CERs has attracted much attention... effects of phytoCER-based oral dietary supplements for skin hydration and skin barrier reinforcement have been indicated in several studies.
Tessema EN et al. · Skin Pharmacology and Physiology (2017)
Review of phyto-derived ceramides (phytoCERs) as the backbone of intercellular lipid membranes in the stratum corneum
Oral phytoCER dietary supplements have indicated skin-hydration and barrier-reinforcement effects in animal and human studies
PhytoCERs are preferred over animal-derived ceramides for cosmetic/supplement use