1Systematic Review2014
Ulbricht C, Bramwell R, Catapang M, Giese N, Isaac R, Le TD · J Diet Suppl (2014)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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16 peer-reviewed studies
What the evidence says
Chlorophyll doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality randomised trials published 1983–2026 with a typical study size of 10 participants.
Based on 16 studies · 8 RCTs · 20 total participants
Confidence
Moderate confidenceBy outcome
4 studies in the last 5 years
Ulbricht C, Bramwell R, Catapang M, Giese N, Isaac R, Le TD · J Diet Suppl (2014)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: While promising, these findings require further clinical validation to establish effective therapeutic applications.
Sartore G, Zagotto G, Ragazzi E. · Nutrients (2025)
Egner PA, Wang JB, Zhu YR, Zhang BC, Wu Y, Zhang QN · Proc Natl Acad Sci U S A (2001)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Fujiwara T, Nishida N, Nota J, Kitani T, Aoishi K, Takahashi H · Eur Arch Otorhinolaryngol (2016)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Shaughnessy DT, Gangarosa LM, Schliebe B, Umbach DM, Xu Z, MacIntosh B · PLoS One (2011)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Gao F, Hu XF · Chin J Integr Med (2005)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Christiansen SB, Byel SR, Strømsted H, Stenderup JK, Eickhoff JH · Ugeskr Laeger (1989)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Egner PA, Muñoz A, Kensler TW · Mutat Res (2003)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Nahata MC, Slencsak CA, Kamp J · Drug Intell Clin Pharm (1983)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: The objective of this review is to highlight the value of phyllobilins by compiling current knowledge, with a particular emphasis on their bioactivity and potential impact on human health.
Serra MDR, Pérez-Gálvez A, Roca M. · Antioxidants (Basel, Switzerland) (2026)
In plain English: Chlorophyllin is a cheap, safe, and readily available phytopharmaceutical drug, which is being investigated in the phase 2 study and, if proven effective, can be considered an alternative for treating radionecrosis.
Dasgupta A, Sawant S, Chatterjee A, Gota V, Sahu A, Choudhari A, Bhattacharya K, Puranik A, Dev I, Moiyadi A, Shetty P, Singh V, Menon N, Epari S, Sahay A, Shah A, Bano N, Shaikh F, Jirage A, Gupta T. · Cancer medicine (2025)
In plain English: Additionally, it explores the prospects and potential of microalgae to unlock novel applications in the healthcare field, ultimately providing valuable directions for future research in this burgeoning area.
Shen HL, Zhuang HX, Sun J, Hou J, Xianyu Y, Zhou WW. · Nanoscale (2026)
In plain English: A review situating chlorophyllin among dietary factors that reduce aflatoxin genotoxicity by blocking carcinogen activation/absorption — useful mechanistic context, not new efficacy.
Gross-Steinmeyer K, Eaton DL · Toxicology (2012)
In plain English: A small uncontrolled 8-week pilot reported improvement in fine lines and solar lentigines with a topical chlorophyllin gel — again pilot-grade and not controlled.
Sigler ML, Stephens TJ · J Drugs Dermatol (2015)
In plain English: A small, single-center, uncontrolled 3-week pilot reported that a topical chlorophyllin gel improved acne and pore appearance — promising but low-quality and not placebo-controlled.
Stephens TJ, McCook JP, Herndon JH Jr · J Drugs Dermatol (2015)
In plain English: A case-study report described reduced facial redness with topical chlorophyllin gel — the weakest tier of clinical evidence.
Vasily DB · J Drugs Dermatol (2015)