62 peer-reviewed studies · Evidence score: 9/10
Yang M et al. • Critical reviews in food science and nutrition (2026)
These findings could provide guidance for infant feeding.
Sagaro GG et al. • Journal of Alzheimer's disease : JAD (2023)
α-GPC alone or in combination with donepezil improved cognition, behavior, and functional outcomes among patients with neurological conditions associated with cerebrovascular injury.
Yang Q et al. • European journal of clinical investigation (2023)
Higher levels of circulating choline were associated with a higher risk of CVD and all-cause mortality.
Sharifi-Zahabi E et al. • Nutrition research (New York, N.Y.) (2024)
This study showed that each 100 mg/day increment in choline consumption was significantly associated with a 6% and 11% higher risk of all-cause and cardiovascular disease mortality respectively.
Khodabakhshi A et al. • Nutrition and cancer (2023)
The present study demonstrates that serum TAMO levels were insignificantly associated with cancer incidence.
Chen X et al. • Archives of physical medicine and rehabilitation (2022)
VR rehabilitation training promotes the rehabilitation of cognitive function and recovery of ADL in patients with PSCI and may be a good complementary approach to conventional cognitive interventions.
Ma W et al. • European radiology (2022)
The DRs of PSMA-radiotracers were greater than those of choline-radiotracers and fluciclovine-radiotracers at the patient level. 18F-labeled PSMA achieved a higher DR than 68Ga-labeled PSMA.
Millard HR et al. • American Journal of Clinical Nutrition (2021)
Higher choline intake was not associated with increased cardiovascular disease risk and may provide modest protection against coronary heart disease.
Moretti A et al. • Nutrients (2020)
Our scoping review elucidates and summarizes the crucial role of choline in modulating muscle fat metabolism, muscle proteins homeostasis, and the modulation of inflammation and autophagy.
Ylilauri MP et al. • The American Journal of Clinical Nutrition (2019)
Higher choline intake was associated with a reduced risk of dementia and better cognitive performance in prospective cohort analyses.
Poly C et al. • American Journal of Clinical Nutrition (2011)
Higher choline intake was associated with better cognitive performance.
Pînzariu O et al. • Journal of investigative medicine : the official publication of the American Federation for Clinical Research (2023)
Matrix-assisted laser desorption/ionization coupled with MS imaging confirmed the functional nature of GH-secreting PAs and accurately discriminated PAs from healthy pituitary tissue.
Evangelista L et al. • Nuclear medicine communications (2016)
The presence of high heterogeneity among the studies should be considered carefully.
Nguyen HT et al. • Nutrition reviews (2025)
The existing guidelines highlight the importance of choline in supporting maternal health and fetal development during pregnancy.
Thomson AR et al. • Neuroscience and biobehavioral reviews (2024)
Data were extracted and grouped by metabolite, brain region and several other factors before calculation of standardised effect sizes.
Van Puyvelde H et al. • Cancer epidemiology (2023)
This study did not suggest an effect of dietary intake of methionine, choline, nor betaine on breast cancer risk, mainly due to the lack of precision of the combined risk estimates as few studies are available.
Tammenmaa-Aho I et al. • The Cochrane database of systematic reviews (2018)
TD remains a major public health problem.
Razavi SA et al. • Cancer medicine (2024)
It appears that the field of TC metabolomics will experience notable advancement, leading to the discovery of trustworthy diagnostic and prognostic biomarkers.
Xu M et al. • Diabetes care (2022)
Our study identified the causal roles of SGLT2 inhibition in choline metabolites.
Obeid R et al. • Advances in nutrition (Bethesda, Md.) (2022)
Low maternal choline intake/circulating concentrations were associated with a higher OR for NTDs among 1131 mothers of newborns with NTDs and 4439 control mothers (pooled estimate = 1.36; 95% CI: 1...