1Meta-Analysis2017
Sawangjit R, Puttarak P, Saokaew S, Chaiyakunapruk N · Phytother Res (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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17 peer-reviewed studies
What the evidence says
Most Cissus Quadrangularis studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2006–2026 with a typical study size of 354 participants.
Based on 17 studies · 2 meta-analyses · 11 RCTs · 602 total participants
Confidence
High confidenceBy outcome
8 studies in the last 5 years · Latest meta-analysis: 2025
Sawangjit R, Puttarak P, Saokaew S, Chaiyakunapruk N · Phytother Res (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Panpimanmas S, Sithipongsri S, Sukdanon C, Manmee C · J Med Assoc Thai (2010)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ross SM · Holist Nurs Pract (2012)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Altaweel AA, Baiomy AABA, Shoshan HS, Abbas H, Abdel-Hafiz AA, Gaber AE · BMC Oral Health (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Kuate D, Nash RJ, Bartholomew B, Penkova Y · Nat Prod Commun (2015)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Nash R, Azantsa B, Kuate D, Singh H, Oben J · J Altern Complement Med (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T · Phytomedicine (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Oben J, Kuate D, Agbor G, Momo C, Talla X · Lipids Health Dis (2006)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Oben JE, Ngondi JL, Momo CN, Agbor GA, Sobgui CS · Lipids Health Dis (2008)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Chatree S, Sitticharoon C, Maikaew P, Pongwattanapakin K, Keadkraichaiwat I, Churintaraphan M · Sci Rep (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Jain A, Dixit J, Prakash D · J Int Acad Periodontol (2008)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: However, the absence of standardized formulations, small sample sizes, short follow-ups, and lack of head‑to‑head comparisons with standard anti‑osteoporotic therapies currently available underscore the need for long-term, multicenter randomized controlled studies using bioavailable, well-characterized CQ preparations.
Manocchio N, Sorbino A, Devito A, Gallelli L, Romanello D, Rotunno S, Foti C, Migliore A. · Orthopedic research and reviews (2026)
In plain English: Conclusion It seems that plant-derived medicines have beneficial effects on bone and may manage osteoporosis by affecting different targets and pathways involved in osteoporosis; However, Future studies are needed to confirm the effectiveness and safety of these preparations.
Karimi SM, Bayat M, Rahimi R. · Journal of traditional and complementary medicine (2024)
In plain English: Clinical trial number Not applicable.
Na Takuathung M, Aisara J, Sawong S, Koonrungsesomboon N. · BMC complementary medicine and therapies (2025)
In plain English: These findings indicate that both botanicals are promising natural agents for managing obesity through incretin-based mechanisms.
Youovop J, Takuissu G, Minoue R, Nwang F, Adegboyega M, Arrey C, Makamwe I, Oben J. · Medicina (Kaunas, Lithuania) (2025)
In plain English: Cissus protected the microarchitecture of the long bones from ovariectomy-induced bone loss, likely via the BMP and Wnt signaling pathways.
Guerra JM, Hanes MA, Rasa C, Loganathan N, Innis-Whitehouse W, Gutierrez E, Nair S, Banu J · J Bone Miner Metab (2019)
In plain English: Cissus suppressed RANKL-induced osteoclastogenesis and preserved bone microarchitecture by shifting the host osteoimmune balance toward anti-osteoclastogenic immune cells.
Azam Z, Sapra L, Baghel K, Sinha N, Gupta RK, Soni V, Saini C, Mishra PK, Srivastava RK · Cells (2023)