We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Cqu4.0
Cissus Quadrangularis Research
Mostly mechanism / observational
17 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Cissus Quadrangularis studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2006–2026 with a typical study size of 354 participants.
Based on 17 studies · 2 meta-analyses · 11 RCTs · 602 total participants
Confidence
High confidence
By outcome
Weight managementProprietary Cissus combination products reduced body weight and improved lipids/glucose vs placebo in trials, but single-ingredient data are weaker · 6-8 weeks
Mostly mechanism / observational7 studies
Bone healthMay support fracture healing and slow bone-turnover markers; meta-analysis showed benefit for fractures but a controlled trial found no change in bone mineral density · 6-24 weeks
Mostly mechanism / observational6 studies
Safety profile
Too few graded studies1 study
Active research area
8 studies in the last 5 years · Latest meta-analysis: 2025
200620162026
1Meta-Analysis2017
Sawangjit R, Puttarak P, Saokaew S, Chaiyakunapruk N · Phytother Res (2017)
Jain A, Dixit J, Prakash D · J Int Acad Periodontol (2008)
12Review2026
In plain English: However, the absence of standardized formulations, small sample sizes, short follow-ups, and lack of head‑to‑head comparisons with standard anti‑osteoporotic therapies currently available underscore the need for long-term, multicenter randomized controlled studies using bioavailable, well-characterized CQ preparations.
Manocchio N, Sorbino A, Devito A, Gallelli L, Romanello D, Rotunno S, Foti C, Migliore A. · Orthopedic research and reviews (2026)
In postmenopausal osteopenia, randomized trials show that 24‑week oral CQ stabilizes bone turnover markers and delays bone loss, albeit without short‑term gains in bone mineral density.
Published in Orthopedic research and reviews (2026)
In plain English: Conclusion It seems that plant-derived medicines have beneficial effects on bone and may manage osteoporosis by affecting different targets and pathways involved in osteoporosis; However, Future studies are needed to confirm the effectiveness and safety of these preparations.
Karimi SM, Bayat M, Rahimi R. · Journal of traditional and complementary medicine (2024)
It seems that multi-component herbal preparations were more effective than single-component ones; because of the synergistic effects of their constituents.
The investigated herbal medicines demonstrated their promising results in osteoporosis via targeting different pathways in bone metabolism, including balancing osteoblasts and osteoclasts, anti-inflammatory, immunomodulatory, antioxidant, and estrogen-like functions.
Conclusion It seems that plant-derived medicines have beneficial effects on bone and may manage osteoporosis by affecting different targets and pathways involved in osteoporosis; However, Future studies are needed to confirm the effectiveness and safety of these preparations.
In plain English: Clinical trial number Not applicable.
Na Takuathung M, Aisara J, Sawong S, Koonrungsesomboon N. · BMC complementary medicine and therapies (2025)
The summary effect measure was the standardized mean difference (SMD) with 95% confidence intervals (95% CI).
The analysis revealed that CQ intervention significantly elevated serum parathyroid hormone levels (SMD = 1.23; 95% CI = 0.79 to 1.67; p < 0.0001).
Conclusion The CQ intervention was significantly associated with increased serum parathyroid hormone levels, with no significant effects on other bone-related biomarkers.
In plain English: These findings indicate that both botanicals are promising natural agents for managing obesity through incretin-based mechanisms.
Youovop J, Takuissu G, Minoue R, Nwang F, Adegboyega M, Arrey C, Makamwe I, Oben J. · Medicina (Kaunas, Lithuania) (2025)
Results : Participants receiving DGE or CQE displayed notable elevations in circulating GLP-1 (+38.6 pg/mL and +42.2 pg/mL, respectively; p < 0.01) and significant reductions in DPP-4 activity (-15.3% and -17.8%; p < 0.01) compared with placebo.
Both extracts produced substantial improvements in body weight (-5.2% and -5.8%), body fat (-10.3% and -10.9%), energy intake (-16.2% and -17.5%), and satiety (+25.6% and +27.4%) ( p < 0.01).
Significant changes in fasting glucose and serum lipid levels were also observed ( p < 0.05).
In plain English: Cissus protected the microarchitecture of the long bones from ovariectomy-induced bone loss, likely via the BMP and Wnt signaling pathways.
Guerra JM, Hanes MA, Rasa C, Loganathan N, Innis-Whitehouse W, Gutierrez E, Nair S, Banu J · J Bone Miner Metab (2019)
Ovariectomized rats fed Cissus for 3 months retained trabecular bone in femur and tibia
In plain English: Cissus suppressed RANKL-induced osteoclastogenesis and preserved bone microarchitecture by shifting the host osteoimmune balance toward anti-osteoclastogenic immune cells.