Ci7.0

Cistanche Research

25 peer-reviewed studies · Evidence score: 7/10

Bioactive Components, Pharmacological Properties, and Applications of Cistanche deserticola Y. C. Ma: A Comprehensive Review

Liu X et al. • Nutrients (2025)

By integrating ethnopharmacological wisdom with modern scientific evidence, this work lays a robust foundation for advancing the applications of C. deserticola in nutraceuticals and therapeutics.

Mechanism analysis elucidated its anti-fatigue and immune-enhancing activities, primarily through the modulation of pivotal signaling pathways, including NF-κB, AMPK, and TLR4.
The review also highlights recent regulatory advancements in China, which have approved C. deserticola as a functional food ingredient, complementing its traditional uses in kidney yang tonification and promoting intestinal health.
Despite its promising attributes, challenges related to sustainable cultivation and clinical application remain.

Systematic Review

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Acteoside as a rising star for clinical treatment: Current fundamental research and future outlooks

Zhang FK et al. • Journal of integrative medicine (2026)

Acteoside as a rising star for clinical treatment: Current fundamental research and future outlooks.

Acteoside as a rising star for clinical treatment: Current fundamental research and future outlooks.
J Integr Med. 2026; 24(1):7-23.

Systematic Review

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A systematic review of the traditional uses, chemistry, and curative aptitude of echinacoside-a phenylethanoid glycoside

Baidya R et al. • Naunyn-Schmiedeberg's archives of pharmacology (2025)

The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

The ECH contents in the reported plants often own these multifaceted properties, highlighting their importance in clinical research.
Evident from its therapeutic efficacy, there is a huge potential for a comprehensive understanding of the mechanisms of actions of ECH, which underscores the need for more research in this area.
The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Systematic Review

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The potential, challenges, and prospects of polysaccharides from the genus Cistanche as therapeutic agents for aging-related diseases: A review

Tao J et al. • International journal of biological macromolecules (2025)

Given the critical role of CPS in biological research and drug discovery, this paper systematically reviews recent advancements in CPS research, encompassing extraction, isolation, purification met...

Given the critical role of CPS in biological research and drug discovery, this paper systematically reviews recent advancements in CPS research, encompassing extraction, isolation, purification methods, structural characterization, pharmacological activities, and potential mechanisms of action.
The paper also explores the potential mechanisms of action of CPS in mitigating age-related degenerative changes.
This review aims to provide a theoretical foundation for the advancing study of polysaccharides from the genus Cistanche and the development of functional foods targeting age-related health issues.Copyright © 2025 Elsevier B.V.

Systematic Review

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[Research progress on Parkinson's disease treatment with traditional Chinese medicine via regulating Nrf2/HO-1 signaling pathway]

Shu L et al. • Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2025)

It also discusses the mechanisms by which TCM active ingredients(flavonoids, alkaloids, terpenes, saponins, polyphenols, etc.), single herbs(Cistanche deserticola, Uraria crinite, and Melissa officinalis, etc.), and formulas(Bushen Jianpi Decoction, Didang Decoction, and Gancao Yangyin Decoction, etc.) modulate the Nrf2/HO-1 pathway in PD treatment, providing a theoretical basis for the clinical application and new drug development of TCM in PD prevention and treatment.

The nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1) signaling pathway plays a critical role in cellular antioxidation, anti-inflammation, and cellular repair mechanisms, which are crucial for neuroprotection against PD.
Studies indicate that TCM regulates the Nrf2/HO-1 pathway to enhance neuronal antioxidative capacity, inhibit neuroinflammation, promote dopaminergic neuron repair and survival, and slow pathological progression.
Further research warranted to confirm findings

Systematic Review

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Mechanistic Insights into the Anticancer Potential of Echinacoside: Therapeutic Applications and Future Directions

Sheokand A et al. • Archiv der Pharmazie (2025)

This manuscript also comprehensively integrates the latest preclinical findings, particularly highlighting emerging nanotechnological and synergistic strategies designed to overcome its bioavailability and stability barrier, thereby uniquely outlining a strategic roadmap for future research to facilitate the clinical application of echinacoside into precision oncology.

Additionally, echinacoside has significant synergistic potential with traditional chemotherapeutics, enhancing cytotoxicity while mitigating systemic toxicity and overcoming drug resistance.
Despite compelling evidence for its multi-targeted anticancer mechanisms, its clinical translation is restricted by various pharmacokinetic challenges, including limited absorption and fast metabolic clearance.
Although few reviews have addressed the general pharmacological activities of echinacoside, this article provides a novel and forward-looking perspective by critically bridging the gap between its multi-targeted anticancer mechanisms and its translational potential.

Systematic Review

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Cistanche flavonoids activate the Keap1-Nrf2-ARE signaling pathway in improving cognitive dysfunction in Alzheimer's disease: A review

Zhao R et al. • Journal of Alzheimer's disease : JAD (2025)

This comprehensive analysis underscores their therapeutic potential in alleviating AD through oxidative stress reduction and antioxidant activation.

This process significantly increases the production of antioxidant enzymes, such as superoxide dismutase and glutathione peroxidase.
Elevated enzyme levels enhance cellular antioxidant defenses, reduce oxidative damage at the cellular and neuronal levels, and improve cognitive function in AD mouse models.
The study examined the molecular composition of Cistanche flavonoids and their impact on the Keap1-Nrf2-ARE pathway, revealing their potential in mitigating AD-related changes.

Systematic Review

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Considering traditional Chinese medicine as adjunct therapy in the management of chronic constipation by regulating intestinal flora

Wang K et al. • Bioscience trends (2024)

We hope this review can contribute to an understanding of TCM as an adjunct therapy for chronic constipation and that it can provide useful information for the development of more effective constipation therapies.

Therefore, we reviewed the relationship between intestinal flora and chronic constipation as well as advances in research on TCM as adjunct therapy in the management of chronic constipation by regulating intestinal flora.
Moreover, some external forms of TCM, and especially acupuncture, have also been found to improve intestinal movement and alleviate constipation symptoms by regulating intestinal flora.
We hope this review can contribute to an understanding of TCM as an adjunct therapy for chronic constipation and that it can provide useful information for the development of more effective constipation therapies.

Systematic Review

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The role of Cistanches Herba and its ingredients in improving reproductive outcomes: A comprehensive review

Li Z et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)

Herba and its active ingredients also exhibit pleasing safety.

Herba is a promising source of natural medicine for infertility.
Additionally, compared to current therapeutic drugs, its favorable safety also supports its development as a nutritional supplement.
However, high-quality clinical studies are required to validate its effectiveness for the development of novel therapeutic strategies.

Systematic Review

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Chemical composition, pharmacological effects, and parasitic mechanisms of Cistanche deserticola: An update

Zhang S et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)

In recent years, C. deserticola has garnered considerable attention due to its distinctive pharmacological properties.

In recent years, C. deserticola has garnered considerable attention due to its distinctive pharmacological properties.
This comprehensive review aims to establish a scientific foundation for the development of potential novel drugs and the enhancement of both the quantity and quality of C. deserticola.
It accomplishes this by meticulously analyzing and evaluating the latest research findings pertaining to its chemical composition, pharmacological impacts, and parasitic mechanisms.

Systematic Review

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Unveiling the Therapeutic Potential and Conservation Strategies for Rare and Endangered Medicinal Plants in Traditional Chinese Medicine: A Comprehensive Review

Rastogi S et al. • Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology (2024)

When rare and threatened medical plants from Traditional Chinese Medicine (TCM) are used in modern medicine, it can improve health and help protect wildlife.

When rare and threatened medical plants from Traditional Chinese Medicine (TCM) are used in modern medicine, it can improve health and help protect wildlife.
Using both old information and new science discoveries together can lead to new treatments and long-term uses for these plant materials.
Large-scale clinical studies, new ways of growing plants, and looking into how TCM herbs and regular drugs can work together should be the main topics of future study.

Systematic Review

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Advance in Cistanche deserticola Y. C. Ma. polysaccharides: Isolation, structural characterization, bioactivities and application: A review

Xue T et al. • International journal of biological macromolecules (2024)

However, there is currently no comprehensive review available concerning CDPs.

However, there is currently no comprehensive review available concerning CDPs.
Meanwhile, the shortcomings of CDPs research are further discussed in detail, and new valuable insights for future CDPs research as therapeutic agents and functional foods are proposed.Copyright © 2024 Elsevier B.V.

Systematic Review

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Cistanche Deserticola for Regulation of Bone Metabolism: Therapeutic Potential and Molecular Mechanisms on Postmenopausal Osteoporosis

Wang C et al. • Chinese journal of integrative medicine (2023)

The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature.

Therefore, Cistanche deserticola has attracted increasing attention for its efficacy in the prevention and treatment of osteoporosis in recent years.
Our objective is to clarify the mechanism of Cistanche deserticola in the treatment of osteoporosis.
The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature.

Systematic Review

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Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review

Zhang F et al. • Phytotherapy research : PTR (2022)

In order to better understand the research status of loganin and promote its application in human health, this paper systematically summarized the phytochemistry, analysis methods, synthesis, pharmacological properties and related mechanisms, and pharmacokinetics based on the research in the past decades.

Loganin, an IG, is one of the main active ingredient of Cornus officinalis Sieb. et Zucc., which approved as a medicinal and edible plant in China.
Loganin has been widely concerned due to its extensive pharmacological effects, including anti-diabetic, antiinflammatory, neuroprotective, and anti-tumor activities, etc.
Studies have shown that these underlying mechanisms include anti-oxidation, antiinflammation and anti-apoptosis by regulating a variety of signaling pathways, such as STAT3/NF-κB, JAK/STAT3, TLR4/NF-κB, PI3K/Akt, MCP-1/CCR2, and RAGE/Nox4/p65 NF-κB signaling pathways.

Systematic Review

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Cistanches Herba, from an endangered species to a big brand of Chinese medicine

Song Y et al. • Medicinal research reviews (2021)

The current review summarizes the research progresses concerning the distribution and cultivation, phytochemistry, pharmacology, metabolism and product development of CH in the past decades, and the emerging challenges and developing prospects are discussed as well.

Due to the parasitic nature of Cistanche plants, the wild source was once endangered and listed in the Appendix II of Convention on International Trade in Endangered Species of Wild Fauna and Flora.
Noteworthily, great achievements have reached concerning the research and development of relevant products, such as modern drugs, traditional Chinese medicine prescriptions, and dietary supplements.
The current review summarizes the research progresses concerning the distribution and cultivation, phytochemistry, pharmacology, metabolism and product development of CH in the past decades, and the emerging challenges and developing prospects are discussed as well.

Systematic Review

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Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery

Shen CY et al. • British journal of pharmacology (2017)

To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc.

Systematic review examining Cistanche efficacy
Further research warranted to confirm findings

Systematic Review

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Cistanche deserticola Y. C. Ma, "Desert ginseng": a review

Wang T et al. • The American journal of Chinese medicine (2012)

This review summarizes the up-to-date and comprehensive information on C. deserticola covering the aspects of the botany, traditional uses, phytochemistry, and pharmacology.

The dried fleshy stem of C. deserticola has been generally used as a tonic in China and Japan for many years.
The phenylethanoid glycosides (PhGs) presented in C. deserticola have been identified as the major active components.
This review summarizes the up-to-date and comprehensive information on C. deserticola covering the aspects of the botany, traditional uses, phytochemistry, and pharmacology.

Systematic Review

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Phenylethanoid Glycosides from Cistanche deserticola Y. C. Ma: Synergistic Effects, Multi-target Mechanisms and Translational Applications

Liu X et al. • Nutrients (2026)

PhGs from C. deserticola possess distinct pharmacological effects and broad application prospects.

PhGs from C. deserticola possess distinct pharmacological effects and broad application prospects.
Future research should emphasize in-depth structure-activity relationship investigations, multi-component synergistic mechanisms, safety evaluation, and formulation design to enhance bioavailability, thus promoting the industrial development and application of PhGs.
Further research warranted to confirm findings

Systematic ReviewAI-discovered

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A randomized, double-blind, placebo-controlled study of Cistanche tubulosa and Ginkgo biloba extracts for the improvement of cognitive function in middle-aged and elderly people

Chen L et al. • Phytotherapy research : PTR (2024)

These findings indicated that CG supplementation could potentially serve as an effective supplementary solution for enhancing cognitive and memory functions.

Moreover, cognitive-related blood biomarkers, including total tau, pT181, pS199, pT231, pS396, and thyroid-stimulating hormone, significantly decreased, whereas triiodothyronine and free triiodothyronine significantly increased.
Notably, both the Cognitrax matrix test and the Wechsler Memory Scale-Revised demonstrated enhanced memory functions, including long-term and delayed memory, after CG intervention.
No treatment-related adverse events were reported, and routine blood and urine tests remained stable.

RCTn=100

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Effects of Cistanche deserticola Y.C. Ma Supplementation on Muscle Strength and Recovery: A Randomized Controlled Trial

Tao B et al. • Nutrients (2025)

Daily supplementation with 5 g of CD extract for eight consecutive weeks significantly enhanced muscle strength and endurance in males with different training backgrounds and facilitated post-exercise recovery by modulating hormonal responses and reducing stress levels and inflammation.

Among untrained individuals, the CD group showed significantly greater improvements in 1RM bench press and squat compared with the PLAC group (p < 0.05), with MVIC and RTF also significantly increased (p < 0.01).
Serum cortisol levels were reduced (p < 0.05), and significant improvements were observed in testosterone, CRP, and CK (p < 0.01).
In trained individuals, CD supplementation led to significant increases in 1RM squat and MVIC (p < 0.05), along with improvements in testosterone and cortisol levels (p < 0.05) and marked reductions in CRP and CK (p < 0.01).

RCTn=48

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