1Meta-Analysis2023
Rastgoo S, Shimi G, Shiraseb F, Karbasi A, Ashtary-Larky D, Yousefi M · Front Immunol (2023)
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142 peer-reviewed studies
What the evidence says
Most CLA studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2000–2026 with a typical study size of 1,476 participants.
Based on 142 studies · 21 meta-analyses · 115 RCTs · 5,700 total participants
Confidence
High confidenceBy outcome
16 studies in the last 5 years · Latest meta-analysis: 2024
Rastgoo S, Shimi G, Shiraseb F, Karbasi A, Ashtary-Larky D, Yousefi M · Front Immunol (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Liang CW, Cheng HY, Lee YH, Liou TH, Liao CD, Huang SW · Nutr Rev (2023)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Mirzaii S, Mansourian M, Derakhshandeh-Rishehri SM, Kelishadi R, Heidari-Beni M · Nutrition (2016)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Schoeller DA, Watras AC, Whigham LD · Appl Physiol Nutr Metab (2009)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Asbaghi O, Shimi G, Naseri K, Saadati S, Kelishadi MR, Doaei S · Eur J Pharmacol (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Morvaridzadeh M, Estêvão MD, Morvaridi M, Belančić A, Mohammadi S, Hassani M · Prostaglandins Other Lipid Mediat (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Namazi N, Irandoost P, Larijani B, Azadbakht L · Crit Rev Food Sci Nutr (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Suksatan W, Putera HD, Abdulkadhim AH, Hammid AT, Ismailov JA, Jannat B · Clin Nutr ESPEN (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Haghighatdoost F, Nobakht M Gh BF · Eur J Clin Nutr (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Haghighat N, Shimi G, Shiraseb F, Karbasi A, Nadery M, Ashtary-Larky D · Pharmacol Res (2022)
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Ghodoosi N, Rasaei N, Goudarzi K, Hashemzadeh M, Dolatshahi S, Omran HS · Nutr J (2023)
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Derakhshande-Rishehri SM, Mansourian M, Kelishadi R, Heidari-Beni M · Public Health Nutr (2015)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Mazidi M, Karimi E, Rezaie P, Ferns GA · Cardiovasc Ther (2017)
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Onakpoya IJ, Posadzki PP, Watson LK, Davies LA, Ernst E · Eur J Nutr (2012)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Whigham LD, Watras AC, Schoeller DA · Am J Clin Nutr (2007)
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Rahbar AR, Ostovar A, Derakhshandeh-Rishehri SM, Janani L, Rahbar A · Endocr Metab Immune Disord Drug Targets (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Yang J, Wang HP, Zhou LM, Zhou L, Chen T, Qin LQ · Lipids Health Dis (2015)
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Haghighatdoost F, Hariri M · Endocr Metab Immune Disord Drug Targets (2018)
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Mohammadi-Sartang M, Sohrabi Z, Esmaeilinezhad Z, Aqaeinezhad R SM, Jalilpiran Y · Horm Metab Res (2018)
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In plain English: Future research should focus on personalized approaches to CLA supplementation, considering genetic and lifestyle factors for tailored nutritional guidance.
Rajendran M, Palani S, Singh TG, Oliver B, Dua K, Subramaniyan V, Narayanan K. · Food science & nutrition (2025)