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Cln3.0

Clenbuterol Research

Mostly mechanism / observational

30 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Clenbuterol studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from high-quality randomised trials published 1977–2026 with a typical study size of 113 participants.

Based on 30 studies · 22 RCTs · 127 total participants

Confidence

Moderate confidence

By outcome

Muscle / lean mass (animal)Muscle/anti-catabolic effects seen in animals only; no human physique evidence and significant cardiac/electrolyte risk. · Not established in humans
Mostly mechanism / observational5 studies
Cardiac toxicity
Mostly mechanism / observational5 studies
Safety profile
Mostly mechanism / observational5 studies
Fat loss & repartitioning (animal)Produces leaner carcasses in animals, but there is no human fat-loss RCT, and it causes cardiac toxicity (tachycardia, arrhythmia, MI), hypokalemia, and tremor. Banned in sport and not human-approved in the US. · Not established in humans
Mostly mechanism / observational4 studies

Steady research

5 studies in the last 5 years

197720012026

1Systematic Review2023

Kumari S, Pal B, Sahu SK, Prabhakar PK, Tewari D · Int J Legal Med (2023)

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2RCT1987

Kovács L, Mészáros G, Pál A, Szász K · Zentralbl Gynakol (1987)

3RCT2008

Kamalakkannan G, Petrilli CM, George I, LaManca J, McLaughlin BT, Shane E · J Heart Lung Transplant (2008)

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4RCT2000

Ishiko O, Ushiroyama T, Saji F, Mitsuhashi Y, Tamura T, Yamamoto K · Int J Gynaecol Obstet (2000)

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5RCT1987

Crimi N, Palermo F, Cacopardo B, Vancheri C, Oliveri R, Palermo B · Eur J Respir Dis (1987)

6RCT1990

Yamamoto H, Nagata M, Tabe K, Suzuki S, Maruo H, Sakamoto Y · Arerugi (1990)

7RCT1980

Keelan P, Gray P, Cox GA · Ir Med J (1980)

8RCT2018

Koeberl DD, Case LE, Smith EC, Walters C, Han SO, Li Y · Mol Ther (2018)

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9RCT1986

Weisbach W, Wagner F, Jäger KH · Zentralbl Gynakol (1986)

10RCT1989

Valente Mérida J, Medina J · Rev Alerg Mex (1987) (1989)

11RCT1985

Schaffler K, Schuster D · Arzneimittelforschung (1985)

12RCT1980

Brusasco V, Crimi E, Mangini S, Vibelli C · Curr Med Res Opin (1980)

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13RCT1980

Villate Navarro JI, Sobradillo Peña V, Atxotegui Iraola-Goitia V, Uresandi Romero F, Sánchez García J · Rev Clin Esp (1980)

14RCT1988

Boner AL, Vallone G, Brighenti C, Schiassi M, Miglioranzi P, Richelli C · Pediatr Pulmonol (1988)

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15RCT1983

Pasargiklian R, Monti G, Bertulessi C · Minerva Ginecol (1983)

16RCT1977

Dorow P · Arzneimittelforschung (1977)

17RCT1983

Jaffé G, Grimshaw JJ · Pharmatherapeutica (1983)

18RCT1993

Maltin CA, Delday MI, Watson JS, Heys SD, Nevison IM, Ritchie IK · Clin Sci (Lond) (1993)

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19RCT1982

Wheatley D · Curr Med Res Opin (1982)

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20RCT1983

Agostini M, Barlocco G, Mastella G · Eur J Respir Dis Suppl (1983)

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Clenbuterol Research

Mostly mechanism / observational

Adverse events of clenbuterol among athletes: a systematic review of case reports and case series.

[Tocolysis with clenbuterol tablets].

Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure.

beta(2)-adrenergic agonists and pelvic floor exercises for female stress incontinence.

Bronchodilator effect of Aerochamber and Inspirease in comparison with metered dose inhaler.

[The inhibitory effect of long-acting beta-adrenergic agonists, mabuterol, clenbuterol and fenoterol on "morning dipping" in patients with asthma].

A multiple-dose response study of clenbuterol in bronchial asthma.

Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease.

[Oral long-term tocolysis of threatened premature labor using clenbuterol (Contraspasmin, Spiropent). A placebo-controlled double-blind method].

[Placebo-controlled comparative study of clenbuterol and terbutaline in asthmatic children].

[Novel quantitative assessment of the tremorogenic effects of the beta 2-mimetics clenbuterol and salbutamol after oral administration].

A clinical trial of oral clenbuterol (NAB 365) in chronic airways obstruction.

[Action of 3 beta-mimetic bronchodilators: clenbuterol, hexoprenaline, fenoterol. Comparative study].

Comparison of the protective effect and duration of action of orally administered clenbuterol and salbutamol on exercise-induced asthma in children.

[Clenbuterol in the treatment of premature labor].

[The bronchodilatory effect of fenoterol-HBr in comparison to the new beta2-bronchodilator (NAB 365, clenbuterol-HCl) (author's transl)].

Clenbuterol and salbutamol in the symptomatic treatment of patients with reversible airways obstruction.

Clenbuterol, a beta-adrenoceptor agonist, increases relative muscle strength in orthopaedic patients.

Clenbuterol ("Spiropent'): a long-acting bronchodilator.

Protective effect of fenoterol spray, ipratropium bromide plus fenoterol spray, and oral clenbuterol, on exercise-induced asthma in children. Double blind controlled and randomized clinical trial.