1Meta-Analysis2024
Zhao C, Hao X, Cai W, Zeng LF, Zhao W, Li X · PLoS One (2024)
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336 peer-reviewed studies
What the evidence says
Most Colchicine studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1974–2026 with a typical study size of 808 participants.
Based on 335 studies · 87 meta-analyses · 219 RCTs · 52,789 total participants
Confidence
High confidenceBy outcome
146 studies in the last 5 years · Latest meta-analysis: 2026
Zhao C, Hao X, Cai W, Zeng LF, Zhao W, Li X · PLoS One (2024)
Liu W, Wang H, Su C, Kuang S, Xiong Y, Li Y · Biomed Res Int (2022)
Cueva-Cañola LE, Tapia C, Torres Castro AP, Espinosa-Temaxte CE, Castillo Bringas VA, Zuñiga-Montaño KP · Med Clin (Barc) (2026)
Tucker B, Goonetilleke N, Patel S, Keech A · Heart (2024)
Al-Abdouh A, Barbarawi M, Khan SU, Osman M, Upadhrasta S, Solipuram V · Coron Artery Dis (2021)
Escalera E, Saver JL · J Stroke Cerebrovasc Dis (2025)
Samuel M, Tardif JC, Bouabdallaoui N, Khairy P, Dubé MP, Blondeau L · Can J Cardiol (2021)
De-Miguel-Balsa E, Estevan-Ortega R, Sempere-Selva MT, Latour-Pérez J, Baeza-Román A, Moya-Martinez A · Eur Rev Med Pharmacol Sci (2021)
Wang MK, Razeghi G, Eikelboom JW, Devereaux PJ, Budgeon CA, Jacka MJ · Can J Cardiol (2024)
Hemkens LG, Ewald H, Gloy VL, Arpagaus A, Olu KK, Nidorf M · Cochrane Database Syst Rev (2016)
Hariyanto TI, Halim DA, Jodhinata C, Yanto TA, Kurniawan A · Clin Exp Pharmacol Physiol (2021)
Khandkar C, Vaidya K, Patel S · Clin Ther (2019)
Desai D, Maheta D, Agrawal SP, Shah AB, Panchal A, Shah H · Panminerva Med (2025)
Brophy JM · Can J Cardiol (2025)
Imazio M, Brucato A, Forno D, Ferro S, Belli R, Trinchero R · Heart (2012)
Kofler T, Kurmann R, Lehnick D, Cioffi GM, Chandran S, Attinger-Toller A · J Am Heart Assoc (2021)
Aw KL, Koh A, Lee HL, Kudzinskas A, De Palma R · Open Heart (2022)
Fallahtafti P, Farooqi M, Looha MA, Azizpour A, Mohammadi Y, Fekri M · BMC Cardiovasc Disord (2025)
Yasmin F, Najeeb H, Moeed A, Hassan W, Khatri M, Asghar MS · PLoS One (2022)
Ballacci F, Giordano F, Conte C, Telesca A, Collini V, Imazio M · J Cardiovasc Med (Hagerstown) (2025)