Col9.0

Collagen Research

78 peer-reviewed studies · Evidence score: 9/10

Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis

Almohanna HM et al. • The American Journal of Medicine (2025)

23 RCTs showed improvements in hydration, elasticity, and wrinkles, though quality of studies varied.

23 RCTs with 1474 participants
High-quality studies showed less effect
Funding source influenced outcomes

Meta-Analysisn=1,474

DOI

Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials

Simental-Mendía M et al. • Clinical and experimental rheumatology (2025)

The results of this meta-analysis suggest that oral collagen administration relieves OA symptoms.

The meta-analysis revealed an overall significant improvement of both function [MD, -6.46 (95% CI -9.52, -3.40); I2=75%; p=0.00001] and pain scores [MD, -13.63 (95% CI -20.67, -6.58); I2=88%; p=0.00001], favouring collagen supplementation.
The results of this meta-analysis suggest that oral collagen administration relieves OA symptoms.
Our findings revealed noteworthy improvements, statistically and clinically, in both functional and pain scores.

Meta-Analysisn=870

DOI

Treatment outcomes of regenerative endodontic therapy in immature permanent teeth with pulpal necrosis: A systematic review and network meta-analysis

Sabeti M et al. • International endodontic journal (2024)

Limited evidence suggests both PRP and PRF exhibit success in the short-term, not long-term.

Six interventions from nine included studies were identified: blood clot scaffold (BC), blood clot scaffold with basic fibroblast growth factor, blood clot scaffold with collagen, platelet pellet, platelet-rich plasma (PRP) and platelet-rich fibrin (PRF).
The PRP scaffold showed the greatest increase in root lengthening at 6-12 months (MD = 4.2; 95% CrI, 1.2 to 6.8; SUCRA = 89.0%, very low confidence).
Blood clot scaffold (with collagen or combined with basic fibroblast growth factor (bFGF)) achieved the highest level of success for secondary outcomes beyond 12 months follow-up.

Meta-Analysisn=3,021

DOI

Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis

Bischof K et al. • Sports medicine (Auckland, N.Z.) (2024)

This systematic review and meta-analysis represents the first comprehensive investigation into the effects of long-term CP supplementation combined with regular physical training on various aspects of musculoskeletal health in adults.

This systematic review and meta-analysis represents the first comprehensive investigation into the effects of long-term CP supplementation combined with regular physical training on various aspects of musculoskeletal health in adults.
The findings indicate significant, though of low to moderate certainty, evidence of improvements in fat-free mass (FFM), tendon morphology, muscle mass, maximal strength, and recovery in reactive strength following exercise-induced muscle damage.
However, further research is required to fully understand the mechanisms underlying these effects, particularly regarding tendon mechanical properties and short-term adaptations to collagen peptide (CP) intake without exercise, as observed in recovery outcomes.

Meta-Analysisn=768

DOI

Effects of Hydrolyzed Collagen as a Dietary Supplement on Fibroblast Activation: A Systematic Review

Inacio PAQ et al. • Nutrients (2024)

Hydrolyzed collagens or collagen peptides with molecular sizes ranging from <3 to 3000 KDa promote the stimulation of fibroblasts in human tissues.

Hydrolyzed collagens or collagen peptides with molecular sizes ranging from <3 to 3000 KDa promote the stimulation of fibroblasts in human tissues.
Further research warranted to confirm findings

Systematic Review

DOI

A systematic review and meta-analysis of nutritional and dietary interventions in randomized controlled trials for skin symptoms in children with atopic dermatitis and without food allergy: An EAACI task force report

Vassilopoulou E et al. • Allergy (2024)

Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

A meta-analysis of 20 RCTs assessing probiotics, alone or combined with prebiotics, revealed a significant reduction in SCORAD scores, suggesting a consistent trend in alleviating AD symptoms in children without food allergies.
The review encompassed 27 RCTs examining prebiotics, Vitamin D, evening primrose oil, and substituting cow's milk formula with partially hydrolyzed whey milk formula.
Nonetheless, evidence for other dietary interventions remains limited, underscoring the necessity for well-designed intervention studies targeting multiple factors to understand etiological interactions and propose reliable manipulation strategies.

Meta-Analysis

DOI

Infant Formulas With Partially or Extensively Hydrolyzed Milk Proteins for the Prevention of Allergic Diseases: A Systematic Review and Meta-Analysis of Clinical Trials

Li X et al. • Advances in nutrition (Bethesda, Md.) (2024)

GRADE was low for the evidence that, compared with CMF, infants early fed with EHF had lower risk of cow's milk allergy at age 0-2 y [relative risk (RR): 0.62; 95% CI: 0.39, 0.99].

GRADE was low for the evidence that, compared with CMF, infants early fed with EHF had lower risk of cow's milk allergy at age 0-2 y [relative risk (RR): 0.62; 95% CI: 0.39, 0.99].
Moderate evidence supported that PHF and EHF reduced risk of eczema in children aged younger or older than 2 y, respectively (RR: 0.71; 95% CI: 0.52, 0.96; and RR: 0.79; 95% CI: 0.67, 0.94, respectively).
We also identified moderate systematic evidence indicating that PHF reduced risk of wheeze at age 0-2 y compared with CMF (RR: 0.50; 95% CI: 0.29, 0.85), but PHF and EHF increased the risk compared with BM (RR: 1.61; 95% CI: 1.11, 2.31; and RR: 1.64; 95% CI: 1.26, 2.14).

Meta-Analysis

DOI

Bioinductive patch as an augmentation for rotator cuff repair, a systematic review and meta-analysis

Warren JR et al. • Journal of shoulder and elbow surgery (2024)

The bioinductive collagen patch appears to be a safe augmentation for rotator cuff repair.

Overall retear rate after full thickness RCR augmented with the bioinductive patch was 8.3%.
For partial thickness RCR, total retear rate was of 1.1% across all patients.
The overall complication rate with the bioinductive patch was 15.5% across all full-thickness RCR studies and 16.2% in partial thickness RCR.

Meta-Analysis

DOI

Autogenous graft versus collagen matrices for peri-implant soft tissue augmentation. A systematic review and network meta-analysis

Tommasato G et al. • Clinical oral investigations (2024)

While CTG demonstrated better performance in all the comparison and FGG showed to be the best graft to increase keratinized mucosa up to 90 days, ADM and VCMX may be used to increase soft tissue horizontal thickness with lower patients' morbidity.

While CTG demonstrated better performance in all the comparison and FGG showed to be the best graft to increase keratinized mucosa up to 90 days, ADM and VCMX may be used to increase soft tissue horizontal thickness with lower patients' morbidity.
Further research warranted to confirm findings

Meta-Analysisn=10

DOI

Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis

Liu X et al. • British journal of sports medicine (2018)

The overall analysis including all trials showed that supplements provided moderate and clinically meaningful treatment effects on pain and function in patients with hand, hip or knee osteoarthritis at short term, although the quality of evidence was very low.

Another six (undenatured type II collagen, avocado soybean unsaponifiables, methylsulfonylmethane, diacerein, glucosamine and chondroitin) revealed statistically significant improvements on pain, but were of unclear clinical importance.
Chondroitin demonstrated statistically significant, but not clinically important structural improvement (effect size -0.30, -0.42 to -0.17).
The overall analysis including all trials showed that supplements provided moderate and clinically meaningful treatment effects on pain and function in patients with hand, hip or knee osteoarthritis at short term, although the quality of evidence was very low.

Meta-Analysis

DOI

Comparative Meta-Analysis of the Effect of Concentrated, Hydrolyzed, and Isolated Whey Protein Supplementation on Body Composition of Physical Activity Practitioners

A Castro LH et al. • Nutrients (2019)

Due to several and important limitations, more detailed analyses are required regarding FFM gain.

Random effect meta-analyses were performed from the final and initial body composition values of 246 healthy athletes undergoing 64.5 ± 15.3 days of training in eight randomized clinical trials (RCT) collected systematically from five scientific databases.
There was no significant effect on FFM in any of the scenarios investigated (p > 0.05).
Due to several and important limitations, more detailed analyses are required regarding FFM gain.

Meta-Analysis

DOI

Collagen supplementation for skin health: A mechanistic systematic review

Barati M et al. • Journal of cosmetic dermatology (2020)

In this systematic review, three different mechanisms of action were clarified for the intervention.

In this systematic review, three different mechanisms of action were clarified for the intervention.
Direct effects of collagen peptides on fibroblasts, M2-like macrophages, and oral tolerance-related mechanisms are the possible mechanisms for the beneficial effects of collagen supplementation.
Further research warranted to confirm findings

Systematic Review

DOI

Effect of alveolar ridge preservation interventions following tooth extraction: A systematic review and meta-analysis

Avila-Ortiz G et al. • Journal of clinical periodontology (2019)

Alveolar ridge preservation is an effective therapy to attenuate the dimensional reduction of the alveolar ridge that normally takes place after tooth extraction.

Alveolar ridge preservation is an effective therapy to attenuate the dimensional reduction of the alveolar ridge that normally takes place after tooth extraction.
Further research warranted to confirm findings

Meta-Analysisn=22

DOI

Guided Bone Regeneration with Collagen Membranes and Particulate Graft Materials: A Systematic Review and Meta-Analysis

Wessing B et al. • The International journal of oral & maxillofacial implants (2018)

Guided bone regeneration with particulate graft materials and resorbable collagen membranes is an effective technique for lateral alveolar ridge augmentation.

The membrane exposure rate of cross-linked membranes was approximately 30% higher than that of non-cross-linked membranes.
Guided bone regeneration with particulate graft materials and resorbable collagen membranes is an effective technique for lateral alveolar ridge augmentation.
Because implant survival rates for simultaneous and subsequent implant placement were similar, simultaneous implant placement is recommended when possible.

Meta-Analysis

DOI