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Coq8.0
CoQ10 – Forschung
Hilft wahrscheinlich
322 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
CoQ10 scheint in 14 von 19 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1993–2026 mit einer typischen Studiengröße von 371 Teilnehmenden.
Basierend auf 320 Studien · 68 Meta-Analysen · 218 RCTs · 39,358 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
14geholfen1unklar4nicht geholfen· 301 weitere ohne bewertete Effektdaten
Nach Outcome
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung49 Studien
Heart & blood pressureReduzierte Müdigkeit, insbesondere bei bestehendem Mangel · 2-4 weeks
Überwiegend Mechanismus / Beobachtung33 Studien
Glucose & metabolicMitochondriale und kardiovaskuläre Unterstützung · Langfristig
Überwiegend Mechanismus / Beobachtung23 Studien
Energy & fatigueBessere Belastungstoleranz und Regeneration · 4-8 weeks
Überwiegend Mechanismus / Beobachtung22 Studien
Fertility & reproductiveReduzierte Falten in einer kleinen RCT mit oralem CoQ10 · 12 weeks
Gemischte Evidenz18 Studien
Cholesterol & lipidsReduzierte Müdigkeit, insbesondere bei bestehendem Mangel · 2-4 weeks
Überwiegend Mechanismus / Beobachtung15 Studien
InflammationUnterstützt die mitochondriale ATP-Produktion und die metabolische Effizienz · 8-12 weeks
Überwiegend Mechanismus / Beobachtung12 Studien
Migraine & headache
Überwiegend Mechanismus / Beobachtung9 Studien
Endurance & exercise performanceVerbesserte kardiale Energieproduktion und Blutdruck innerhalb von 4-8 Wochen · 4-8 weeks
Überwiegend Mechanismus / Beobachtung6 Studien
Neuroprotection & brain agingUnterstützt einen gesunden Östrogenstoffwechsel und das hormonelle Gleichgewicht · 4-8 weeks
Überwiegend Mechanismus / Beobachtung6 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung5 Studien
Skin healthUnterstützt die neuronale mitochondriale Energie · 8-12 weeks · Modest improvement in skin smoothness/elasticity · 12 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
Vision & eye health
Überwiegend Mechanismus / Beobachtung3 Studien
In Zahlen
Aus 53 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
92%
über Studien hinweg
Untersuchte Personen
39k
typische Studie: 371 Personen
Stärkste Designs
286
68 gepoolt, 218 randomisiert
Zeigte Nutzen
74%
14/19 Studien
Wie lange Studien liefen
1–3 Monate
1
3+ Monate
4
Untersuchte Populationen
Heart failure patients3
Poor ovarian response patients undergoing IVF-ET1
Women with polycystic ovary syndrome1
General population1
Aktives Forschungsgebiet
100 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
199320092026
1Meta-Analysen=574 · large study2026
Einfach gesagt: In this updated Cochrane systematic review, meta-analysis of results on the ataxia rating scale showed that pharmacological treatments probably make little or no difference compared with placebo after 12 months of treatment.
Lyons S et al. · The Cochrane database of systematic reviews (2026)
Meta-analysis of seven studies demonstrated that pharmacological treatment probably makes little or no difference to scores on the ataxia rating scale after 12 months of treatment (SMD 0.02, 95% CI -0.23 to 0.26; I² = 42%; 7 studies, 513 participants; moderate-certainty evidence).
The evidence was very uncertain about the effects of treatment on IVSTd (MD -0.51, 95% CI -1.10 to 0.09; I² = 80%; 2 studies, 72 participants; very low-certainty evidence) and on ADL (MD -0.59, 95% CI -1.39 to 0.21; I² = 24%; 3 studies, 167 participants; very low-certainty evidence).
Meta-analysis of three studies showed that treatment probably improves upper limb dexterity (SMD -0.42, 95% CI -0.73 to -0.11; I² = 0%; 3 studies, 166 participants; moderate-certainty evidence).
2Clinical pregnancy rateMeta-Analysen=2,323 · very large study2023
Einfach gesagt: Compared with COS regimen, the adjuvant use of CoQ10, DHEA and GH before IVF may have a better clinical effect on the pregnancy outcome of POR patients.
Zhu F et al. · Reproductive biology and endocrinology : RB&E (2023)
Sehr groß Schaden
← SchlechterKein EffektBesser →
Compared with the control group, CoQ10 (OR 2.22, 95% CI: 1.05 to 4.71) and DHEA (OR 1.92, 95% CI: 1.16 to 3.16) had obvious advantages in improving the clinical pregnancy rate.
CoQ10 was the best in improving the live birth rate (OR 2.36, 95% CI: 1.07 to 5.38).
DHEA increased the embryo implantation rate (OR 2.80, 95%CI: 1.41 to 5.57) and the high-quality embryo rate (OR 2.01, 95% CI: 1.07 to 3.78) and number of oocytes retrieved (WMD 1.63, 95% CI: 0.34 to 2.92) showed a greater advantage, with GH in second place.
4Inflammatory mediatorsMeta-Analysen=1,517 · large study2023
Einfach gesagt: This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.
Hou S et al. · Molecular nutrition & food research (2023)
This meta-analysis provides evidence for CoQ10 supplementation to reduce the level of inflammatory mediators in the general population and proposes that daily supplementation of 300-400 mg CoQ10 show superior inhibition of inflammatory factors.
5Clinical pregnancy ratesMeta-Analysen=2,617 · very large study2024
Einfach gesagt: The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to...
Shang Y et al. · Advances in nutrition (Bethesda, Md.) (2024)
The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to higher clinical pregnancy rates.
Appropriate antioxidant treatment should be offered at a low dose according to the patient's age and ovarian reserve.
7Lipid profile improvementMeta-Analysen=2,794 · very large study2022
Einfach gesagt: CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC.
Liu Z et al. · The Journal of clinical endocrinology and metabolism (2022)
CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC.
8All-cause mortalityMeta-Analysen=1,573 · large study2021
Einfach gesagt: The included studies provide moderate-quality evidence that coenzyme Q10 probably reduces all-cause mortality and hospitalisation for heart failure.
Al Saadi T et al. · The Cochrane database of systematic reviews (2021)
Groß Nutzen
← SchlechterKein EffektBesser →
Coenzyme Q10 probably reduces the risk of all-cause mortality more than control (RR 0.58, 95% CI 0.35 to 0.95; 1 study, 420 participants; number needed to treat for an additional beneficial outcome (NNTB) 13.3; moderate-quality evidence).
There was low-quality evidence of inconclusive results between the coenzyme Q10 and control groups for the risk of myocardial infarction (RR 1.62, 95% CI 0.27 to 9.59; 1 study, 420 participants), and stroke (RR 0.18, 95% CI 0.02 to 1.48; 1 study, 420 participants).
Coenzyme Q10 probably reduces hospitalisation related to heart failure (RR 0.62, 95% CI 0.49 to 0.78; 2 studies, 1061 participants; NNTB 9.7; moderate-quality evidence).
11Live birth rateMeta-AnalyseCited 102×n=7,760 · very large study2020
Einfach gesagt: In this review, there was low- to very low-quality evidence to show that taking an antioxidant may benefit subfertile women.
Showell MG et al. · The Cochrane database of systematic reviews (2020)
Sehr groß Schaden
← SchlechterKein EffektBesser →
Likely real
Due to the very low-quality of the evidence we are uncertain whether antioxidants improve live birth rate compared with placebo or no treatment/standard treatment (odds ratio (OR) 1.81, 95% confidence interval (CI) 1.36 to 2.43; P < 0.001, I2 = 29%; 13 RCTs, 1227 women).
This suggests that among subfertile women with an expected live birth rate of 19%, the rate among women using antioxidants would be between 24% and 36%.
Low-quality evidence suggests that antioxidants may improve clinical pregnancy rate compared with placebo or no treatment/standard treatment (OR 1.65, 95% CI 1.43 to 1.89; P < 0.001, I2 = 63%; 35 RCTs, 5165 women).
12Migraine duration reductionMeta-Analysen=371 · medium study2021
Einfach gesagt: CoQ10 appears to have beneficial effects in reducing duration and frequency of migraine attack.
Sazali S et al. · BMJ open (2021)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
There is no statistically significant reduction in severity of migraine headache with CoQ10 supplementation.
CoQ10 supplementation reduced the duration of headache attacks compared with the control group (MD: -0.19; 95% CI: -0.27 to -0.11; random effects; I2 statistic=0%; p<0.00001).
CoQ10 usage reduced the frequency of migraine headache compared with the control group (MD: -1.52; 95% CI: -2.40 to -0.65; random effects; I2 statistic=0%; p<0.001).
Einfach gesagt: Co-Q10 supplementation slightly but significantly reduced fasting blood glucose, but not fasting insulin and HbA1c.
Moradi M et al. · Archives of Iranian Medicine (2016)
Our preliminary meta-analysis on 14 eligible studies regarding the effect of Co-Q10 supplementation on FBG indicated a slightly significant decrement (SMD:-0.28 mg/d; 95% CI: -0.12, 0.04), with a substantial between-study heterogeneity.
The effect of Co-Q10 on HbA1c and fasting insulin was not significant.
Co-Q10 supplementation slightly but significantly reduced fasting blood glucose, but not fasting insulin and HbA1c.
18Meta-Analyse2015
Banach M, Serban C, Sahebkar A, Ursoniu S, Rysz J, Muntner P · Mayo Clin Proc (2015)