Ck6.0

Cramp Bark Research

10 peer-reviewed studies · Evidence score: 6/10

Historical Review of Ethnopharmacology in Karelia (1850s-2020s): Herbs and healers

Kolosova V et al. • Journal of ethnopharmacology (2022)

Karelians and Russians are very disproportionally represented in the literature due to the lack of interest in the folk medicine of Russians in Karelia, in contrast to that of Karelians.

Karelians and Russians are very disproportionally represented in the literature due to the lack of interest in the folk medicine of Russians in Karelia, in contrast to that of Karelians.
The disparity does not allow adequate comparison, but nonetheless the available data demonstrate that the remedies shared by both ethnic groups are quite few.
The review also contributes to research on the relationship of folk medicine and various state institutions in Russia/the Soviet Union.

Systematic Reviewn=104

DOI

Fruits of Wild-Grown Shrubs for Health Nutrition

Stabnikova O et al. • Plant foods for human nutrition (Dordrecht, Netherlands) (2024)

The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

These fruits have a great potential to be used in functional food making.
The possibilities of using the fruits of wild-grown shrubs in the preparation of functional foods and examples of their implementation for the manufacturing of dairy, bakery and meat products are considered.
The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Systematic Review

DOI

Viburnum opulus L. — A Review of Phytochemistry and Biological Effects

Kajszczak D, Zaklos-Szyda M, Podsedek A • Nutrients (2020)

Viburnum opulus demonstrates antispasmodic, anti-inflammatory, and antioxidant activities supported by its rich polyphenolic composition.

Confirmed antispasmodic activity through multiple mechanisms including calcium channel modulation
Identified chlorogenic acid, catechin, and procyanidins as primary bioactive compounds
Demonstrated anti-inflammatory activity via inhibition of pro-inflammatory cytokines

Systematic Review

DOI

Gilaburu extract (Viburnum opulus Linnaeus) is as effective as Tamsulosin in medical expulsive therapy of distal ureteral calculi

Gok B et al. • International journal of clinical practice (2021)

V. opulus can be used effectively and safely for the treatment of MET in distal ureteral calculi.

Additional analgesic requirement and need for emergency admission were found to be lower in the Viburnum opulus group (37.2% vs 65.1%, P = .017 and 11.6% vs 34.8%, P = .02, respectively).
V. opulus can be used effectively and safely for the treatment of MET in distal ureteral calculi.
Further research warranted to confirm findings

RCTn=86

DOI

Flavonoids and Phenolic Acids Content in Cultivation and Wild Collection of European Cranberry Bush Viburnum opulus L

Goławska S et al. • Molecules (Basel, Switzerland) (2023)

The present study shows the potential of naturally grown and wild V. opulus for the human.

The dominant phenolic acids were p-coumaric and gallic acids.
The major flavonoids found in V. opulus leaves were myricetin and kaempferol.
Temperature and plant location affected the concentration of tested phenolic compounds.

Observational

DOI

Viburnum opulus: could it be a new alternative, such as lemon juice, to pharmacological therapy in hypocitraturic stone patients?

Tuglu D et al. • Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica (2014)

There was no difference between them in terms of the amount of magnesium and citrate.

Potassium was found to be statistically significantly higher in V. opulus than that in lemon juice (p = 0.006) whereas sodium (p = 0.004) and calcium (p = 0.008) were found to be lower.
Further research warranted to confirm findings

Observational

DOI

Gilaburu (Viburnum opulus L.) fruit extract has potential therapeutic and prophylactic role in a rat model of acetic acid-induced oxidant colonic damage

Gülada BÖ et al. • Journal of ethnopharmacology (2024)

Gilaburu shows both anti-inflammatory and antioxidant effects against AA-induced colonic damage by suppressing neutrophil infiltration, regulating inflammatory mediators, inhibiting reactive species production, lipid peroxidation, and apoptosis, conserving endogenous antioxidant glutathione, and ameliorating oxidative DNA damage.

Since the current ulcerative colitis drugs display limited benefits and adverse side effects, potential therapeutic and/or prophylactic role of gilaburu can be evaluated in ulcerative colitis.
Further research warranted to confirm findings

Animal

DOI

Biological Activities and Phytochemical Profile of Viburnum opulus Fruit Extracts

Zaklos-Szyda M, Majewska I, Redzynia M, Koziolkiewicz M • Molecules (2020)

Viburnum opulus fruit extracts exhibited potent antioxidant and cytoprotective properties in cellular models.

Potent antioxidant activity comparable to established antioxidant supplements
Cytoprotective effects against oxidative stress in cell models
Significant anti-diabetic potential through alpha-glucosidase inhibition

Preclinical

DOI

Cost-effective isolation of Viburnum opulus-derived nanovesicles and evaluation of their cytotoxic, anticancer, and antioxidant properties on human glioblastoma cell line U87MG

Giritlioglu NI et al. • Medical oncology (Northwood, London, England) (2025)

This observational examined the effects of Cramp Bark.

Glioblastoma is the most common and highly invasive glial tumor, significantly reducing patient survival.
Analyses including clonogenic cell survival, wound healing, apoptosis, total antioxidant status, and total oxidant status were continued on only U87MG cells, as human dermal fibroblasts showed a low response to nanovesicle treatment.
Qualitative and quantitative assessments demonstrated that Viburnum opulus-derived nanovesicles effectively inhibited cancer cell proliferation and migration.

In Vitro

DOI

An In Vitro Study of the Effect of Viburnum opulus Extracts on Key Processes in the Development of Staphylococcal Infections

Wójcik-Bojek U et al. • Molecules (Basel, Switzerland) (2021)

Nevertheless, their usefulness as diet supplements that are beneficial for the prevention of staphylococcal infections should be confirmed in animal models in the future.

Due to the very high percentage of drug-resistant strains, the participation of drug-tolerant biofilms in pathological changes, and thus the limited number of effective antibiotics, there is an urgent need to search for alternative methods of prevention or treatment for S. aureus infections.
The cytotoxicity of V. opulus extracts to the human fibroblast line HFF-1 was also tested (MTT reduction).
V. opulus extracts strongly inhibited SrtA activity and SpA expression, caused modifications of S. aureus cell membrane, limited biofilm formation by staphylococci, and were non-cytotoxic.

In Vitro

DOI

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