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Ck3.5
Cramp Bark Research
Mostly mechanism / observational
7 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Cramp Bark studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality randomised trials published 2014–2025 with a typical study size of 86 participants.
Based on 7 studies · 1 RCT · 86 total participants
Confidence
Low confidence
What the studies found
1helped· 6 more without graded effect data
By outcome
Therapeutic & ethnobotany
Mostly mechanism / observational5 studies
Inflammation
Mostly mechanism / observational3 studies
Pain & analgesia
Too few graded studies1 study
Active research area
4 studies in the last 5 years
201420192025
1Systematic ReviewCited 5×2024
Stabnikova O et al. · Plant foods for human nutrition (Dordrecht, Netherlands) (2024)
These fruits have a great potential to be used in functional food making.
The possibilities of using the fruits of wild-grown shrubs in the preparation of functional foods and examples of their implementation for the manufacturing of dairy, bakery and meat products are considered.
3Medical expulsive therapy effectiveness for distal ureteral calculiRCTCited 3×n=86 · small study2021
V. opulus can be used effectively and safely for the treatment of MET in distal ureteral calculi.
Gok B et al. · International journal of clinical practice (2021)
Huge benefit
← WorseNo effectBetter →
Likely real
Additional analgesic requirement and need for emergency admission were found to be lower in the Viburnum opulus group (37.2% vs 65.1%, P = .017 and 11.6% vs 34.8%, P = .02, respectively).
V. opulus can be used effectively and safely for the treatment of MET in distal ureteral calculi.
4Mineral content comparison for hypocitraturic stone treatmentObservationalCited 2×2014
There was no difference between them in terms of the amount of magnesium and citrate.
Tuglu D et al. · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica (2014)
Likely real
Potassium was found to be statistically significantly higher in V. opulus than that in lemon juice (p = 0.006) whereas sodium (p = 0.004) and calcium (p = 0.008) were found to be lower.
Moreover, FJ and PJ were able to inhibit pancreatic lipase, which potentially could reduce the fat absorption from the intestinal lumen and the storage of body fat in the adipose tissues.
Zakłos-Szyda M, Pietrzyk N, Szustak M, Podsędek A · Nutrients (2020)
Decreased lipid and triacylglycerol accumulation in differentiated 3T3-L1 cells, with downregulation of PPARγ, C/EBPβ/α, and SREBP-1c expression
Reduced levels of lipid-metabolism enzymes (FAS, ACC) and inflammatory cytokines (TNFα, IL-6, leptin)
Inhibited pancreatic lipase activity; chlorogenic acid was the dominant phenolic compound identified
Due to their non-toxic, anticancer, and antioxidant properties, these nanovesicles hold significant potential in glioblastoma management.
Giritlioglu NI et al. · Medical oncology (Northwood, London, England) (2025)
Glioblastoma is the most common and highly invasive glial tumor, significantly reducing patient survival.
Analyses including clonogenic cell survival, wound healing, apoptosis, total antioxidant status, and total oxidant status were continued on only U87MG cells, as human dermal fibroblasts showed a low response to nanovesicle treatment.
Qualitative and quantitative assessments demonstrated that Viburnum opulus-derived nanovesicles effectively inhibited cancer cell proliferation and migration.
Nevertheless, their usefulness as diet supplements that are beneficial for the prevention of staphylococcal infections should be confirmed in animal models in the future.
Wójcik-Bojek U et al. · Molecules (Basel, Switzerland) (2021)
Due to the very high percentage of drug-resistant strains, the participation of drug-tolerant biofilms in pathological changes, and thus the limited number of effective antibiotics, there is an urgent need to search for alternative methods of prevention or treatment for S. aureus infections.
The cytotoxicity of V. opulus extracts to the human fibroblast line HFF-1 was also tested (MTT reduction).
V. opulus extracts strongly inhibited SrtA activity and SpA expression, caused modifications of S. aureus cell membrane, limited biofilm formation by staphylococci, and were non-cytotoxic.