1Systematic Review2016
A Cochrane review found moderate evidence that devil's claw (harpagoside) reduces low-back pain.
Gagnier JJ et al. · Spine (2016)
- Harpagoside ≥50mg/day reduced pain vs placebo
- Cochrane-level evidence
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6 peer-reviewed studies
What the evidence says
Most Devil's Claw studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality studies published 2004–2016.
Based on 6 studies
Confidence
LowBy outcome
Newest study from 2016
A Cochrane review found moderate evidence that devil's claw (harpagoside) reduces low-back pain.
Gagnier JJ et al. · Spine (2016)
A Cochrane review of herbal medicine for low-back pain supported devil's claw among effective herbs.
Oltean H et al. · The Cochrane database of systematic reviews (2014)
A systematic review found Harpagophytum procumbens (devil's claw) effective for osteoarthritis and low-back pain.
Gagnier JJ et al. · BMC complementary and alternative medicine (2004)
An evidence-based review summarized devil's claw's anti-inflammatory/analgesic uses.
Brendler T et al. · Journal of herbal pharmacotherapy (2006)
A systematic review assessed the safety of Harpagophytum preparations.
Vlachojannis J et al. · Phytotherapy research : PTR (2008)
A review of nutraceuticals for osteoarthritis included devil's claw among options.
Ameye LG et al. · Arthritis research & therapy (2006)