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Deglycyrrhizinated Licorice
Licorice root with the problematic compound removed, supporting gut lining healing and digestive comfort without affecting blood pressure.
What the evidence says
Most DGL Licorice studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality randomised trials published 1975–2025 with a typical study size of 296 participants.
Based on 5 studies · 3 RCTs · 1,878 total participants
Confidence
ModerateWhat the studies found
By outcome
DGL Licorice has an evidence score of 6/10 — moderate evidence based on 5 indexed studies, including 1 meta-analysis. Licorice root with the problematic compound removed, supporting gut lining healing and digestive comfort without affecting blood pressure.
The commonly studied dose of DGL Licorice is 380-760mg, 2-4 times daily. Research points to an estimated optimal dose around 2280mg, with a minimum effective dose near 760mg. Individual response varies — start low and adjust.
The best time to take DGL Licorice is between meals. It can be taken on an empty stomach. DGL (deglycyrrhizinated licorice) works by stimulating mucin secretion and enhancing the protective mucosal barrier of the stomach and duodenum.
Ginger Extract
Likely helpsGingerols and shogaols reduce nausea, accelerate gastric emptying, and provide systemic anti-inflammatory benefits.
Inulin
Likely helpsPrebiotic fiber that selectively feeds Bifidobacteria and Lactobacilli, producing short-chain fatty acids for gut health and immunity.
Last reviewed May 2026 · evidence from 16 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
DGL (Deglycyrrhizinated Licorice) is licorice root with glycyrrhizin removed — the compound that can raise blood pressure and cause potassium loss. What remains supports the gut lining, promotes mucus production, and has mild anti-inflammatory effects. Used for heartburn, ulcers, and gut healing. A safer alternative to regular licorice.
Stimulates protective mucus secretion
Supports gut lining repair
How DGL Licorice works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
380-760mg, 2-4 times daily
Can be taken without food
| Form | Type |
|---|---|
| 💊Chewable tablets (for GERD/reflux) | Recommended |
| 💊Capsules | Alternative |
| 🧪Powder | Alternative |
Chewing allows DGL to coat the esophagus and stomach directly. For capsules, open and mix with water for similar effect.
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: Not required
Note: Take 20-30 minutes before meals or between meals. Chewable form allows direct contact with esophagus for reflux.
Based on limited RCT evidence (n=50) and systematic review findings. DGL form preferred to avoid aldosterone effects. Effectiveness estimates conservative given small study sizes.
Reduced acid reflux symptoms
Reduced digestive discomfort
DGL form is generally considered safe
DGL is safe — glycyrrhizin removed
DGL is much safer than regular licorice
Tip: Reduce dose
DGL Licorice is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are headache. Use caution if any of these apply to you: Known allergy or hypersensitivity to DGL Licorice or related compounds; Severe hypertension (even DGL form should be used cautiously).
Resistant Starch
Likely helpsBypasses small intestine digestion to feed colon bacteria that produce butyrate — supports blood sugar, gut integrity, and metabolic health.
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