Deglycyrrhizinated Licorice
Licorice root with the problematic compound removed, supporting gut lining healing and digestive comfort without affecting blood pressure.
DGL (Deglycyrrhizinated Licorice) is licorice root with glycyrrhizin removed — the compound that can raise blood pressure and cause potassium loss. What remains supports the gut lining, promotes mucus production, and has mild anti-inflammatory effects. Used for heartburn, ulcers, and gut healing. A safer alternative to regular licorice.
Stimulates protective mucus secretion
Supports gut lining repair
How DGL Licorice works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
380-760mg, 2-4 times daily
Can be taken without food
| Form | Type |
|---|---|
| 💊Chewable tablets (for GERD/reflux) | Recommended |
| 💊Capsules | Alternative |
| 🧪Powder | Alternative |
Chewing allows DGL to coat the esophagus and stomach directly. For capsules, open and mix with water for similar effect.
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: Not required
Note: Take 20-30 minutes before meals or between meals. Chewable form allows direct contact with esophagus for reflux.
Reduced acid reflux symptoms
Reduced digestive discomfort
DGL form is generally considered safe
DGL is safe — glycyrrhizin removed
DGL is much safer than regular licorice
Tip: Reduce dose
Top studies from 16+ peer-reviewed papers
Shi C et al. • Journal of biomaterials science. Polymer edition (2015)
“As there are still some problems with the development of DGL, further research is warranted for its broad applications.”
da Rocha CMM et al. • Nutrients (2022)
“Conclusions: Among NW adolescents, GL is a better measure of carbohydrate quality, but for those with overweight/obesity, carbohydrate consumption is more associated with GC, probably because they eat/report small amounts of carbohydrates.”
Rabe E et al. • Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (2021)
“This systematic-review examined the effects of DGL Licorice.”
Gu A et al. • The Journal of arthroplasty (2019)
“There is strong evidence that serologic malnutrition was associated with increased risk of poor postoperative outcome across all total joint replacement interventions.”
Wolf J et al. • Gastroenterology (2017)
“In a prospective study, we validated the TTG-IgA procedure and the TTG-DGL procedure in identification of pediatric patients with or without celiac disease, without biopsy.”
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