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Dehydroepiandrosterone
Adrenal hormone precursor that declines with age, supporting hormone balance, energy, and body composition.
What the evidence says
DHEA helped in about half (4/8) of the studies that measured an effect — promising, but not unanimous.
Most evidence is from high-quality meta-analyses and randomised trials published 1999–2026 with a typical study size of 686 participants.
Based on 27 studies · 13 meta-analyses · 1 RCT · 15,617 total participants
Confidence
HighWhat the studies found
By outcome
See full supplement plans that include DHEA.
DHEA has an evidence score of 9/10 — very strong evidence based on 27 indexed studies, including 18 meta-analyses. Adrenal hormone precursor that declines with age, supporting hormone balance, energy, and body composition.
The commonly studied dose of DHEA is 25-50mg for women; 50-100mg for men (start low). Research points to an estimated optimal dose around 75mg, with a minimum effective dose near 25mg. Individual response varies — start low and adjust.
The best time to take DHEA is in the morning. Take it with food. DHEA (dehydroepiandrosterone) is an adrenal steroid hormone precursor with natural circadian secretion peaking in the early morning alongside cortisol.
Last reviewed May 2026 · evidence from 36 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
DHEA is a steroid hormone produced by the adrenal glands that serves as a precursor to testosterone and estrogen. Levels peak in the mid-20s and decline ~2% per year thereafter. Research suggests benefits for energy, mood, bone density, body composition, and sexual function, particularly in those with low levels. A cornerstone of anti-aging medicine.
Converts to testosterone and estrogen
Direct effects on brain function
How DHEA works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
25-50mg for women; 50-100mg for men (start low)
Loading: Start at 25mg and titrate based on blood levels
Take with food
| Form | Type |
|---|---|
| 💊Micronized DHEA capsules | Recommended |
| 💊7-Keto DHEA (doesn't convert to sex hormones) | Alternative |
| 💊Sublingual | Alternative |
7-Keto DHEA may be preferable for those concerned about sex hormone conversion.
Minimum: 8 weeks
Optimal: 16 weeks
Cycling: Monitor DHEA-S levels every 3-6 months. Adjust dose to keep in optimal range.
Note: Take in the morning to mimic natural cortisol/DHEA rhythm. Monitor blood levels.
Based on meta-analysis showing OR 1.92 for clinical pregnancy rate in poor ovarian response patients. Effect specific to fertility treatment context with medical supervision. Limited long-term safety data.
Better energy and mood
May improve muscle/fat ratio
Use lower doses (10-25mg); watch for androgenic effects
Generally not needed unless deficient
Additive hormonal effects
May affect blood sugar
Tip: Reduce dose
Tip: Reduce dose
Tip: Discontinue or switch to 7-Keto
Tip: Adjust dose
DHEA is generally safe at recommended doses, with a few precautions worth noting. The most commonly reported side effects are acne, oily skin/hair, hair loss (androgenic). Use caution if any of these apply to you: Hormone-sensitive cancers (breast, prostate, ovarian); PCOS (may worsen symptoms); Liver disease.
DIM
Likely helpsShifts estrogen metabolism toward beneficial 2-hydroxy metabolites, reducing harmful estrogen dominance in both men and women.
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