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4 peer-reviewed studies
What the evidence says
Most Dihexa studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from mixed-quality studies published 2013–2024.
Based on 4 studies
Confidence
Very lowBy outcome
1 study in the last 5 years
Metabolically stabilized angiotensin IV analogs act as procognitive/antidementia agents in preclinical models.
McCoy, Benoist, Wright, Kawas, Bule-Ghogare, Zhu · The Journal of pharmacology and experimental therapeutics (2013)
Small-molecule angiotensin IV analogs are being developed to treat Alzheimer's and Parkinson's diseases.
Wright, Kawas, Harding · Progress in neurobiology (2015)
The brain HGF/c-Met receptor system is a target for treating Alzheimer's disease.
Wright, Harding · Journal of Alzheimer's disease : JAD (2015)
An angiotensin IV analog improved outcomes in a chemically induced Huntington's-disease-like rodent model.
Wells, Azzam, Hiller, Sardinia · Journal of Huntington's disease (2024)