We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Dul7.0
Dulaglutide Research
Mostly mechanism / observational
128 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Dulaglutide studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2012–2026 with a typical study size of 440 participants.
Based on 128 studies · 13 meta-analyses · 103 RCTs · 92,119 total participants
Confidence
High confidence
By outcome
Blood sugar & glycemic controlLarge, consistent HbA1c reductions across the AWARD phase-3 program; superior to insulin glargine and exenatide · Weeks to months
Mostly mechanism / observational99 studies
Weight managementReal but modest weight reduction (typically a few kilograms, dose-dependent) — less than semaglutide head-to-head · Months
Mostly mechanism / observational16 studies
Cardiovascular outcomes12% relative reduction in major adverse cardiovascular events in the dedicated REWIND outcomes trial (HR 0.88) · Months to years
Mostly mechanism / observational15 studies
Safety & adverse effects
Mostly mechanism / observational10 studies
Active research area
61 studies in the last 5 years · Latest meta-analysis: 2026
201220192026
1Meta-Analysis2024
Li Y, Gong X, Găman MA, Hernández-Wolters B, Velu P, Li Y · Eur J Clin Invest (2024)
Overall, GLP-1 receptor agonist treatment reduced MACE by 12% (HR 0.88, 95% CI 0.82-0.94; p<0.0001)... a broad composite kidney outcome by 17% (0.83, 0.78-0.89; p<0.0001)... There was no increase in risk of severe hypoglycaemia, pancreatitis, or pancreatic cancer.
Class-level 12% reduction in MACE (HR 0.88, 95% CI 0.82-0.94), with 12% lower cardiovascular and all-cause mortality and 9% fewer heart-failure hospitalizations
17% reduction in a composite kidney outcome (HR 0.83), mainly driven by reduced urinary albumin excretion
Mazdutide was generally safe, although the incidence of gastrointestinal adverse events was higher for mazdutide than for dulaglutide.
Guo L, Zhang B, Xue X, Zhang X, Cai H, Jiang H, Zhang L, Jin P, Wang X, Cheng Z, Zhang S, Geng J, Guo Y, Hu H, Ma Q, Li L, Du H, Han-Zhang H, Xue F, Deng H, Qian L, Yang W, DREAMS-2 investigators. · Nature (2026)
Significantly greater reductions in body weight were achieved with mazdutide than with dulaglutide, with a least-squares mean treatment difference of -3.78% for 4 mg mazdutide and -5.76% for 6 mg mazdutide (both P < 0.0001), relative to dulaglutide.
Moreover, significantly more participants who received mazdutide 4 mg or 6 mg reached the composite end point of HbA 1c < 7.0% with a body-weight reduction of at least 5% at week 28 (both P < 0.0001), compared with those who received dulaglutide.
The most common treatment-emergent adverse events were diarrhoea, nausea and vomiting.
Thus, it is crucial that patients and providers alike are aware of these AEs when considering their use.
Joy B, Ramsamooj A, Ibrahim S, Wen J, Hsu N, Frezza E. · Endocrine (2026)
Head-to-head comparisons revealed tirzepatide to carry the highest risk ratios for nausea and diarrhea while semaglutide carries the highest risk ratios for vomiting and constipation.
CONCLUSIONS: Regardless of the GLP-1 RAs used, it is apparent that GI AEs are significant and highly prevalent.
Thus, it is crucial that patients and providers alike are aware of these AEs when considering their use.
Corcoran E, Kettlety M, Mogul U, Azah JN, Cork SC. · Molecular and cellular neurosciences (2026)
While pre-clinical data has been encouraging, clinical evidence remains limited.
Conclusions There is consistent preclinical evidence that GLP-1R agonists are effective in reducing Aβ levels and hyperphosphorylated tau.
While the neuroprotective effect in preclinical studies is clear, clinical findings have so far failed to demonstrate an arresting effect on cognitive.
In conclusion, thevketogenic diet combined with dulaglutide can effectively improve glucose and lipid metabolism, insulin function and quality of life in diabetes mellitus patients.
Gao R, Yan L, Du X, He S, Xue L, Li T, Wei M, Gu Y. · Pakistan journal of pharmaceutical sciences (2025)
The results showed that, in comparison with the control group, the blood glucose and blood lipid levels in the study group were lower than those in the control group after treatment (P<0.05).
The insulin resistance index of the study group was decreased and the insulin sensitivity index was increased (P<0.05).
At the 6-month follow-up, the Pittsburgh Sleep Quality Index score was lower and the quality of life was better in the study group (P<0.05).
He Y, Mi N, Cheng Z, Xue H, Han J, Wang H, Wang H, Wu J, Shi X, Zhao S, Duan B, Zhu Y, Zhou Y, Li F, Wang X, Ling H, Wang S, Li Q, Jiang F, Yang M, Bing S, Zheng Q, Ning J, Guo M, Bu Y, Guan L, Li Y, Yang L, Guo W, Pan H, Li X. · The lancet. Diabetes & endocrinology (2025)
At week 32, mean HbA 1c reductions were 1·91% (SE 0·05; -20·86 mmol/mol [0·53]) with ecnoglutide 0·6 mg, 1·89% (0·05; -20·69 mmol/mol [0·54]) with ecnoglutide 1·2 mg, and 1·65% (0·05; -18·02 mmol/mol [0·53]) with dulaglutide.
Estimated treatment differences versus dulaglutide were -0·26% (95% CI -0·39 to -0·13; -2·84 mmol/mol [-4·29 to -1·38]) with ecnoglutide 0·6 mg and -0·24% (-0·38 to -0·11; -2·67 mmol/mol [-4·14 to -1·20]; p=0·0002 for superiority) with ecnoglutide 1·2 mg.
During the 52 weeks, six (3%) of 206 patients in the ecnoglutide 0·6 mg group, eight (4%) of 208 patients in the ecnoglutide 1·2 mg group, and six (3%) of 207 patients in the dulaglutide group discontinued treatment due to adverse events.
Insulin regimens and specific glucagon-like peptide-1 receptor agonists (GLP-1 RAs) added to metformin-based background therapy produced the greatest reductions in hemoglobin A1c.
Tsapas A, Avgerinos I, Karagiannis T, Malandris K, Manolopoulos A, Andreadis P, Liakos A, Matthews DR, Bekiari E. · Ann Intern Med (2020)
Network meta-analysis of 453 trials assessing 21 antidiabetic interventions across 9 drug classes
GLP-1 receptor agonists (including dulaglutide) added to metformin-based therapy were among the most effective for HbA1c reduction
In patients at increased cardiovascular risk, specific GLP-1 RAs and SGLT2 inhibitors favorably affected vascular outcomes