Zhou Z, Cui Y, Wu J, Ding R, Cai T, Gao Z · BMC Urol (2019)
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62 peer-reviewed studies
What the evidence says
Most Dutasteride studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2006–2026 with a typical study size of 416 participants.
Based on 62 studies · 14 meta-analyses · 38 RCTs · 26,844 total participants
Confidence
High confidenceBy outcome
21 studies in the last 5 years · Latest meta-analysis: 2026
Zhou Z, Cui Y, Wu J, Ding R, Cai T, Gao Z · BMC Urol (2019)
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Lee S, Lee YB, Choe SJ, Lee WS · Acta Derm Venereol (2019)
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Yin T, Qiao Z, Li Y, Li D, Jiang M, An C · Am J Ther (2017)
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Yang Y, Hu H, Zhang H, Liu Z, Zhao F, Yang J · Urol J (2021)
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Gupta AK, Mays RR, Dotzert MS, Versteeg SG, Shear NH, Piguet V · J Eur Acad Dermatol Venereol (2018)
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Corona G, Tirabassi G, Santi D, Maseroli E, Gacci M, Dicuio M · Andrology (2017)
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Zhou Z, Song S, Gao Z, Wu J, Ma J, Cui Y · Clin Interv Aging (2019)
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In plain English: Even short durations (2 weeks) of 5ARI therapy can significantly reduce prostate vascularity.
Hehir CM, Calpin GG, Cullivan O, Daly GR, Dowling GP, Davis NF. · BJU international (2026)
Kuzmenko AV, Kuzmenko VV, Gyaurgiev TA · Urologiia (2018)
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Tsai TF, Choi GS, Kim BJ, Kim MB, Ng CF, Kochhar P · J Dermatol (2018)
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Shanshanwal SJ, Dhurat RS · Indian J Dermatol Venereol Leprol (2017)
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D'Agate S, Wilson T, Adalig B, Manyak M, Palacios-Moreno JM, Chavan C · World J Urol (2020)
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Kramer JJ, Gu L, Moreira D, Andriole G, Csizmadi I, Freedland SJ · J Urol (2022)
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Na Y, Ye Z, Zhang S · Clin Drug Investig (2012)
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Haque N, Masumori N, Sakamoto S, Ye Z, Yoon SJ, Kuo HC · Int J Urol (2018)
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Gaudet M, Vigneault É, Foster W, Meyer F, Martin AG · Radiother Oncol (2016)
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Freitas D, Andriole GL, Freedland SJ, Neto BS, Moreira DM · Urology (2019)
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Kuhlmann PK, Fischer SC, Howard LE, Moreira DM, Andriole GL, Hopp ML · J Urol (2021)
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Sethi A, Sha L, Kumar N, Macias V, Deaton RJ, Gann PH · BJU Int (2018)
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Moreira DM, Fleshner NE, Freedland SJ · J Urol (2015)
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