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Eleutherococcus senticosus (Siberian Ginseng)
Traditional adaptogen used for stress, energy, and endurance — but controlled human trials have not demonstrated efficacy. Distinct from true ginseng.
What the evidence says
Eleuthero doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality meta-analyses and randomised trials published 1986–2022 with a typical study size of 50 participants.
Based on 26 studies · 1 meta-analysis · 16 RCTs · 512 total participants
Confidence
Moderate confidenceWhat the studies found
By outcome
Despite long traditional use, rigorous human trials are disappointing: a systematic review found no endurance benefit, a controlled trial showed no overall efficacy for fatigue, and HPA-axis effects remain unclear, earning only an emerging score.
13 randomised trials
every one checked individually
Every randomised or controlled trial of Eleuthero indexed in PubMed, not a hand-picked subset. Meta-analyses and systematic reviews are deliberately excluded from this count: most of them cover many compounds at once, so counting them would inflate it.
PubMed · as of Jul 2026
5 trials ongoing or recruiting · 5 completed on ClinicalTrials.gov
2 of the completed trials have posted results
Registered trials show research momentum for Eleuthero, not proof of effect — a registration is a plan, and posted results are sponsor-reported, not peer-reviewed. They are never counted toward the evidence rating above.
Browse these trials on ClinicalTrials.govClinicalTrials.gov · as of Oct 2026
Eleuthero, formerly called Siberian Ginseng, is a hardy adaptogen used extensively in Russia for performance, stress, and immune support. Unlike Panax ginseng, it doesn't contain ginsenosides but has its own active compounds (eleutherosides).
Despite its long traditional use, rigorous human trials have been disappointing: a systematic review found no endurance benefit, a controlled trial did not demonstrate overall efficacy for chronic fatigue, and human HPA-axis effects remain unclear. Immune and other effects rest largely on in-vitro and preclinical work.
Generally well tolerated, but current evidence for its headline benefits is weak.
Modulates stress response and improves resilience
Shifted human macrophages toward anti-inflammatory types in cell culture
How Eleuthero works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Insufficient data; avoid
May interfere with digoxin assays
Theoretical interaction A grade for this interaction is held for clinical review and has not been validated, so no severity is given. The precaution still applies: ask a pharmacist about the exact supplement and medicine. Do not stop or change prescribed medicines based on this notice.
Tip: Take earlier in day; reduce dose
Eleuthero has an evidence score of 3.5/10 — emerging evidence based on 26 indexed studies. Traditional adaptogen used for stress, energy, and endurance — but controlled human trials have not demonstrated efficacy. Distinct from true ginseng. Representative study: PMID 33650944.
The commonly studied dose of Eleuthero is 300-1200mg extract (standardized to 0.8% eleutherosides) (a typical label dose, no cited trial of this supplement alone states a dose). Individual needs vary — start at the lower end of the range and adjust based on how you respond.
The best time to take Eleuthero is in the morning. Taking it with food is preferred. Eleuthero (Eleutherococcus senticosus), formerly known as Siberian ginseng, is a mildly stimulating adaptogen containing eleutherosides that support stress resilience and sustained energy.
Eleuthero is generally well-tolerated and considered safe for most healthy adults at recommended doses. Reported side effects are uncommon and include insomnia. Use caution if any of these apply to you: Known allergy or hypersensitivity to Eleuthero or related compounds; Autoimmune conditions; Uncontrolled hypertension.
Rhodiola Rosea
Probably helpsFast-acting adaptogen that combats mental fatigue and improves cognitive performance under stress — works within days, not weeks.
Ashwagandha
Likely helpsReduces cortisol and anxiety while improving sleep quality and physical recovery in stressed adults.
Tyrosine
Too few graded studiesAmino acid precursor to dopamine and norepinephrine, supporting focus and mental performance under stress.
Beetroot
Likely helpsDietary nitrates convert to nitric oxide, enhancing oxygen delivery to muscles — a top-5 evidence-based ergogenic aid.
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Reviewed by Dr. Baher Al Hakim · Last reviewed June 2026 · evidence from 26 studies · how we score · editorial policy
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
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