40 peer-reviewed studies · Evidence score: 8/10
Ba DM et al. • Nutrition journal (2021)
In a meta-analysis of prospective cohort studies, mushroom consumption was associated with a lower risk of all-cause mortality.
Arslan NP et al. • Critical reviews in food science and nutrition (2025)
This review summarizes the antioxidant potential of different fungi (mushrooms, yeasts, and molds)-derived natural compounds such as polysaccharides, pigments, peptides, ergothioneine, ergosterol, phenolics, alkaloids, etc.
Jędrejko M et al. • Nutrients (2025)
Nevertheless, supplementation with anserine and ergothioneine shows promise for enhancing physical performance and recovery, though further research is required to better understand their mechanisms and optimize their use in sports and exercise.
Xu R et al. • International journal of impotence research (2025)
The Author(s), under exclusive licence to Springer Nature Limited.
Lu Y et al. • Advanced biology (2025)
Moreover, recent advancements in SIRT6-regulated compounds (e.g., C3G, BZBS, Fisetin, FNDC5, Lycorine hydrochloride, and Ergothioneine) are discussed as potential therapeutic agents for these mediated diseases.
Syahputra RA et al. • The Journal of nutritional biochemistry (2025)
Clinical and preclinical studies have indicated its involvement in metabolic regulation, endothelial protection, and attenuation of neurodegeneration, further reinforcing its significance as a func...
Wen T et al. • The Journal of nutritional biochemistry (2025)
The unique chemical properties and biological functions of EGT position it as a promising candidate for the research and treatment of metabolic diseases.
Halliwell B et al. • Annual review of food science and technology (2023)
By contrast, α-tocopherol has demonstrated in vivo antioxidant effects in humans.
Granados JC et al. • Pharmacology & therapeutics (2024)
The RSST has general applicability to other multi-specific SLC and ABC "drug" transporters (e.g., OCT1, OCT2, SLCO1B1, SLCO1B3, ABCG2, P-gp, ABCC2, ABCC3, ABCC4).
Pochini L et al. • Biomolecules (2024)
In the present review, we wish to provide a state of the art on OCTN1 and OCTN2 transport function and regulation in relationships with inflammation and inflammatory diseases focusing on the metabolic signature collected in different body districts and gene polymorphisms related to inflammatory diseases.
Jomova K et al. • Archives of toxicology (2023)
This systematic-review examined the effects of Ergothioneine.
Tian X et al. • The British journal of nutrition (2023)
We comment on some of the outstanding research questions in the field and consider the question of whether or not ergothioneine should be considered a conditionally essential micronutrient.
Liu HM et al. • Molecules (Basel, Switzerland) (2023)
We believe that ergothioneine has good prospects in the food and cosmetics industries, and can thus meet some needs of the health and beauty industry.
Tao Z et al. • International journal of medicinal mushrooms (2023)
In this paper, the recent studies on the cultivation, degradation characteristics application, and health effects of P. citrinopileatus are reviewed, and their development trends are discussed.
Takhor NH et al. • Inflammopharmacology (2025)
The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Kondoh H et al. • FEBS letters (2022)
Using these opposing dementia markers, not only diagnosis, but also therapeutic interventions to mitigate cognitive decline may now become possible.
Nakamichi N et al. • Neurochemical research (2022)
The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Cordell GA et al. • Molecules (Basel, Switzerland) (2022)
The history, chemistry, biology, and biosynthesis of the globally occurring histidine-derived alkaloids ergothioneine (10), ovothiol A (11), and selenoneine (12) are reviewed comparatively and their significance to human well-being is discussed.
Holeček M • Nutrients (2020)
Of concern should be findings of hepatic enlargement and increases in ammonia and glutamine and of decrease in branched-chain amino acids (valine, leucine, and isoleucine) in blood plasma indicating that HIS supplementation is inappropriate in patients with liver disease.
Ames BN • Proceedings of the National Academy of Sciences of the United States of America (2018)
Because nutrient deficiencies are highly prevalent in the United States (and elsewhere), appropriate supplementation and/or an improved diet could reduce much of the consequent risk of chronic disease and premature aging.