1Meta-Analysis2025
Jha M, Agrawal SP, Maheta D, Bhattacharjee P, Jain H, Zacks J · Expert Opin Biol Ther (2025)
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141 peer-reviewed studies
What the evidence says
Most Evolocumab (Repatha) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2012–2026 with a typical study size of 115 participants.
Based on 140 studies · 7 meta-analyses · 125 RCTs · 115 total participants
Confidence
High confidenceBy outcome
61 studies in the last 5 years · Latest meta-analysis: 2025
Jha M, Agrawal SP, Maheta D, Bhattacharjee P, Jain H, Zacks J · Expert Opin Biol Ther (2025)
Ge X, Zhu T, Zeng H, Yu X, Li J, Xie S · Biomed Res Int (2021)
Daviglus ML, Ferdinand KC, López JAG, Wu Y, Monsalvo ML, Rodriguez CJ · J Am Heart Assoc (2021)
Gandra SR, Villa G, Fonarow GC, Lothgren M, Lindgren P, Somaratne R · Clin Cardiol (2016)
Toth PP, Descamps O, Genest J, Sattar N, Preiss D, Dent R · Circulation (2017)
Sattar N, Preiss D, Robinson JG, Djedjos CS, Elliott M, Somaratne R · Lancet Diabetes Endocrinol (2016)
He XX, Zhang R, Zuo PY, Liu YW, Zha XN, Shan SS · Eur J Intern Med (2017)
Eslami SM, Nikfar S, Ghasemi M, Abdollahi M · J Pharm Pharm Sci (2017)
AlHajri L, AlHadhrami A, AlMheiri S, AlMutawa Y, AlHashimi Z · Ther Adv Cardiovasc Dis (2017)
Le Thi TG, Geist M, Novosad Y, Litwin A, Gomes D, Grünzner J · Eur J Prev Cardiol (2026)
Wilson PWF, Polonsky TS, Miedema MD, Khera A, Kosinski AS, Kuvin JT · J Am Coll Cardiol (2019)
Pan C, Zhou X, Wang Y, Wu Y, Han Q, Cui X · Expert Opin Drug Saf (2026)
Bandukwala LM, Curley D, Bontinis A, Bontinis V, Shalhoub J · Ann Vasc Surg (2026)
Rosenson RS, Jacobson TA, Preiss D, Djedjos CS, Dent R, Bridges I · Cardiovasc Drugs Ther (2016)
Wang J, Deng S, Liu Y, She Q, Du J · Zhonghua Wei Zhong Bing Ji Jiu Yi Xue (2020)
Karim SR, Jensen NM, Holck EN, Clemmesen TS, Christiansen EH, Jakobsen L · J Heart Lung Transplant (2026)
Ziogos E, Chelko SP, Harb T, Engel M, Vavuranakis MA, Landim-Vieira M · Eur Heart J Cardiovasc Pharmacother (2023)
Peach M, Xu R, Fitzpatrick D, Hamilton L, Somaratne R, Scott R · J Lipid Res (2016)
Leiter LA, Giugliano RP, Marston NA, De Ferrari G, Nicolau JC, Bhatia AK · Diabetes Care (2026)
Stein EA, Honarpour N, Wasserman SM, Xu F, Scott R, Raal FJ · Circulation (2013)