1Meta-Analysis2018
Wu H, Shang H, Wu J · Endocrine (2018)
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209 peer-reviewed studies
What the evidence says
Most Ezetimibe (Zetia) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2003–2026 with a typical study size of 9,438 participants.
Based on 209 studies · 52 meta-analyses · 151 RCTs · 29,455 total participants
Confidence
High confidenceBy outcome
55 studies in the last 5 years · Latest meta-analysis: 2026
Wu H, Shang H, Wu J · Endocrine (2018)
Miao XY, Liu HZ, Jin MM, Sun BR, Tian H, Li J · Eur Rev Med Pharmacol Sci (2019)
Gencer B, Marston NA, Im K, Cannon CP, Sever P, Keech A · Lancet (2020)
Jamialahmadi T, Baratzadeh F, Reiner Ž, Simental-Mendía LE, Xu S, Susekov AV · Mediators Inflamm (2021)
Mahajan K, Nagendra L, Dhall A, Dutta D · Eur J Intern Med (2024)
Awad K, Mikhailidis DP, Katsiki N, Muntner P, Banach M · Drugs (2018)
Luo L, Yuan X, Huang W, Ren F, Zhu H, Zheng Y · Intern Med J (2015)
Benhuri B, Ueyama H, Takagi H, Briasoulis A, Kuno T · Curr Vasc Pharmacol (2021)
Lee HY, Jun DW, Kim HJ, Oh H, Saeed WK, Ahn H · Korean J Intern Med (2019)
Chiu SW, Pratt CM, Feinn R, Chatterjee S · J Cardiovasc Pharmacol Ther (2020)
Bhagavathula AS, Aldhaleei WA, Al Matrooshi NO, Rahmani J · Clin Drug Investig (2020)
Zhang S, Sun T, Song L, Jin X, Li B · Eur J Med Res (2025)
Araya FI, Grassi B · Medwave (2016)
de Oliveira Almeida G, Balieiro C, Bertoli ED, Moreira MEL, Silva ALS, Minucci BS · Coron Artery Dis (2025)
Lorenzi M, Ambegaonkar B, Baxter CA, Jansen J, Zoratti MJ, Davies G · Clin Res Cardiol (2019)
Ragbourne SC, Crook MA · J Clin Lipidol (2015)
Banach M, Jaiswal V, Ang SP, Sawhney A, Deb N, Amarenco P · Mayo Clin Proc (2025)
Lin YC, Lai TS, Wu HY, Chou YH, Chiang WC, Lin SL · Clin Pharmacol Ther (2020)
Thomopoulos C, Skalis G, Michalopoulou H, Tsioufis C, Makris T · Clin Cardiol (2015)
Dolezelova E, Stein E, Derosa G, Maffioli P, Nachtigal P, Sahebkar A · Br J Clin Pharmacol (2017)