We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies

Fa2.5

Fadogia Agrestis Research

Mostly mechanism / observational

3 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Fadogia Agrestis studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from mixed-quality studies published 2005–2023.

Based on 3 studies

Confidence

Very low confidence

By outcome

Men's vitalityRaised testosterone only in rats; no human evidence and animal toxicity signals · Not established in humans · Traditional aphrodisiac use; rat-only data, no human trials · Not established in humans
Mostly mechanism / observational3 studies
Fertility & reproductive
Too few graded studies1 study

Active research area

1 study in the last 5 years

200520142023

1Erectile dysfunction biomarkers restorationAnimalCited 5×2023

The study concluded that AEFAS restored the NO/cGMP pathway and ED-associated key enzymes in the penile and testicular tissues of male rats via antioxidant means.

Ogunro OB et al. · Reproductive sciences (Thousand Oaks, Calif.) (2023)

Contrastingly, AEFAS like sildenafil citrate increased (p < 0.05) the penile and testicular NO, cGMP, catalase, SOD, T-SH, GSH and GST and reduced AChE, PDE5, arginase, ACE, TBARS and H2O2 to levels that compared favourably (p > 0.05) with those of sham control.
The study concluded that AEFAS restored the NO/cGMP pathway and ED-associated key enzymes in the penile and testicular tissues of male rats via antioxidant means.
The study recommended the use of aqueous extract of Fadogia agrestis stem in managing ED after clinical trials.

View source

2Liver and kidney cellular toxicityAnimal2009

The other evidence in this study suggests disruption of the ordered lipid bilayer of the plasma membranes of the hepatocytes and nephrons.

Yakubu MT et al. · Human & experimental toxicology (2009)

Extract administration significantly reduced (p < .05) the activities of alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase in the liver and kidney with corresponding increases in the serum.
Serum malondialdehyde also increased significantly in all the extract-treated groups.
The other evidence in this study suggests disruption of the ordered lipid bilayer of the plasma membranes of the hepatocytes and nephrons.

View source

3AnimalCited 94×2005

The aqueous extract of Fadogia agrestis stem increased the blood testosterone concentrations and this may be the mechanism responsible for its aphrodisiac effects and various masculine behaviors.

Yakubu MT et al. · Asian Journal of Andrology (2005)

There was also a significant increase in serum testosterone concentrations in all the groups in a manner suggestive of dose-dependence.
All the doses resulted in significant increase in mount frequency, intromission frequency.
Phytochemical screening revealed the presence of alkaloids and saponins.

View source Free full text

View in Research Library

Fadogia Agrestis Research

Mostly mechanism / observational

Fadogia agrestis (Schweinf. Ex Hiern) Stem Extract Restores Selected Biomolecules of Erectile Dysfunction in the Testicular and Penile Tissues of Paroxetine-Treated Wistar Rats

Mode of cellular toxicity of aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male rat liver and kidney

Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats