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Fa2.5

Fadogia Agrestis Research

Mostly mechanism / observationalModerate safety

3 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Fadogia Agrestis studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from mixed-quality studies published 2005–2023.

Based on 3 studies

Confidence

Very low

By outcome

Men's vitalityPotential testosterone support within 4-8 weeks · 4-8 weeks · Anecdotal androgen support, limited human data · 4-8 weeks
Mostly mechanism / observational3 studies
Fertility & reproductive
Mostly mechanism / observational3 studies
Safety profile
Too few graded studies2 studies

Active research area

2 studies in the last 5 years

200520142023

1Testosterone enhancement evidence reviewReview2022

There is currently no human clinical trial data supporting Fadogia agrestis for testosterone enhancement; all evidence is derived from rat studies.

Clemesha CG et al. · International Journal of Impotence Research (2022)

No human clinical trials exist - all testosterone data comes from a single rat study
The original animal study showed increased serum testosterone but also testicular toxicity at higher doses
Concerns about heavy metal contamination and lack of standardization in commercial products

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2Erectile dysfunction biomarkers restorationAnimalCited 5×2023

Ogunro OB et al. · Reproductive sciences (Thousand Oaks, Calif.) (2023)

Contrastingly, AEFAS like sildenafil citrate increased (p < 0.05) the penile and testicular NO, cGMP, catalase, SOD, T-SH, GSH and GST and reduced AChE, PDE5, arginase, ACE, TBARS and H2O2 to levels that compared favourably (p > 0.05) with those of sham control.
The study concluded that AEFAS restored the NO/cGMP pathway and ED-associated key enzymes in the penile and testicular tissues of male rats via antioxidant means.
The study recommended the use of aqueous extract of Fadogia agrestis stem in managing ED after clinical trials.

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3AnimalCited 94×2005

Fadogia agrestis extract increased testosterone levels in rats but also caused dose-dependent changes in testicular tissue.

Yakubu MT et al. · Asian Journal of Andrology (2005)

Increased testosterone in rats
Dose-dependent testicular changes observed
Reversible effects at lower doses

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Fadogia Agrestis Research

Mostly mechanism / observational

A critical review of Fadogia agrestis as a testosterone booster: separating hype from evidence

Fadogia agrestis (Schweinf. Ex Hiern) Stem Extract Restores Selected Biomolecules of Erectile Dysfunction in the Testicular and Penile Tissues of Paroxetine-Treated Wistar Rats

Effect of Fadogia agrestis on serum testosterone in rats