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Fisetin (3,3',4',7-tetrahydroxyflavone)
A dietary flavonoid studied as a senolytic. The honest verdict: the striking longevity effects are from mice, and the few small human trials have largely been null or inconclusive.
What the evidence says
Most Fisetin studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality randomised trials published 2014–2026 with a typical study size of 37 participants.
Based on 69 studies · 7 RCTs · 131 total participants
Confidence
Moderate confidenceWhat the studies found
By outcome
Striking senolytic and lifespan effects come from mouse studies; the few small human trials were largely null (Gulf War illness, liver function) or only modestly positive, keeping it emerging.
18 trials ongoing or recruiting · 7 completed on ClinicalTrials.gov
5 of the completed trials have posted results
Registered trials show research momentum for Fisetin, not proof of effect — a registration is a plan, and posted results are sponsor-reported, not peer-reviewed. They are never counted toward the evidence rating above.
Browse these trials on ClinicalTrials.govClinicalTrials.gov · as of Oct 2026
Fisetin is a flavonoid found in strawberries, apples, and other plants. It has drawn attention in longevity research as a candidate senolytic — a compound that may selectively eliminate senescent ('zombie') cells that accumulate with age.
The striking healthspan and lifespan effects come from mouse studies; in humans the evidence is still emerging.
The handful of human trials are small and have largely been null or inconclusive (e.g., no benefit in Gulf War illness or liver-function trials, modest inflammatory changes in a small colorectal-cancer study), and senolytic trials in people are still ongoing. Bioavailability is also poor, complicating translation.
May selectively eliminate senescent cells (demonstrated in animal/preclinical models; not confirmed in humans)
Neutralizes free radicals
Reduces inflammatory signaling
How Fisetin works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Avoid — affects cellular processes
Consult oncologist — senolytics may have complex effects
Like other flavonoids, may have mild antiplatelet activity; theoretical additive effect with anticoagulants/antiplatelets (preclinical, not established in humans) A grade for this interaction is held for clinical review and has not been validated, so no severity is given. The precaution still applies: ask a pharmacist about the exact supplement and medicine. Do not stop or change prescribed medicines based on this notice.
Tip: Take with food
Fisetin has an evidence score of 3.5/10 — emerging evidence based on 69 indexed studies. A dietary flavonoid studied as a senolytic. The honest verdict: the striking longevity effects are from mice, and the few small human trials have largely been null or inconclusive. Representative study: PMID 39203871.
The commonly studied dose of Fisetin is 100-500mg (a typical label dose, not the dose used in the cited trials, the one that states its dose gave 200 mg a day, taken daily for 12 weeks). Individual needs vary — start at the lower end of the range and adjust based on how you respond.
The best time to take Fisetin is with meals. Take it with food. Fisetin is a lipophilic flavonoid with extremely poor native bioavailability due to rapid glucuronidation and sulfation in the gut wall and liver.
Fisetin has a safety rating of "moderate". That is a category, not a measure of individual risk, and there are precautions worth knowing. Reported side effects are uncommon and include GI upset. Use caution if any of these apply to you: Pregnancy (affects cell processes).
CoQ10
Likely helpsA lipid-soluble antioxidant central to mitochondrial energy production, with the strongest trial support for fertility/IVF outcomes and heart failure.
Berberine
Likely helpsActivates AMPK to regulate blood sugar, improve insulin sensitivity, and support lipid metabolism. Its only head-to-head trial with metformin cited here was a 36-person pilot, which does not show it can replace metformin.
Alpha Lipoic Acid
Likely helpsUniversal antioxidant that works in both water and fat, supporting blood sugar control, nerve health, and cellular energy.
Huperzine A
Too few graded studiesAcetylcholinesterase inhibitor from club moss, studied mainly for Alzheimer's and dementia; cognitive evidence is mixed and limited by trial quality.
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Reviewed by Dr. Baher Al Hakim · Last reviewed June 2026 · evidence from 69 studies · how we score · editorial policy
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
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