Fisetin (3,3',4',7-tetrahydroxyflavone)
Flavonoid with potent senolytic properties, may clear damaged cells and support healthy aging.
Fisetin is a flavonoid found in strawberries, apples, and other plants. It's gained significant attention in longevity research as a potent senolytic — a compound that selectively eliminates senescent (damaged, 'zombie') cells that accumulate with age and contribute to aging and disease. Animal studies show remarkable effects, and human trials are underway.
Selectively eliminates senescent cells
Neutralizes free radicals
Reduces inflammatory signaling
How Fisetin works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
100-500mg (intermittent dosing for senolytic effect)
Loading: Some use 'senolytic dosing': 500-1500mg for 2 consecutive days, once monthly
Take with food
| Form | Type |
|---|---|
| 💊Fisetin capsules or powder | Recommended |
| 💊Liposomal fisetin | Alternative |
Bioavailability is limited. Enhanced forms may improve absorption.
Minimum: 4 weeks
Optimal: weeks
Cycling: For senolytic effect: some researchers suggest 2-3 days of high-dose (500-1500mg) monthly or quarterly. Daily low-dose use is also studied.
Note: Fat improves absorption. For senolytic purposes, intermittent high-dose protocols are sometimes used.
Reduces burden of damaged cells
Lower inflammatory markers
Avoid — affects cellular processes
Consult oncologist — senolytics may have complex effects
May have antiplatelet effects — may affect platelet aggregation or vitamin K-dependent clotting factors, altering anticoagulant efficacy
Tip: Take with food
Top studies from 39+ peer-reviewed papers
Lucke-Wold B et al. • Nutritional neuroscience (2025)
“Nutraceuticals and supplements show promising potential in the management of TBI.Trial registration: ClinicalTrials.gov identifier: NCT01814527.Trial registration: ClinicalTrials.gov identifier: NCT03032302.”
López-Gómez L et al. • Nutrients (2024)
“In summary, although certain polyphenols appear to exert some effect, their role in the prevention or treatment of CRC is inconclusive, and more clinical studies under more controlled conditions are needed.”
Joma N et al. • Aging cell (2024)
“Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.”
Wendlocha D et al. • Nutrients (2023)
“In the future, these compounds may find applications in the prevention and treatment of gynecological cancers and breast cancer, but this requires further, more advanced research.”
Wiciński M et al. • Nutrients (2023)
“This review aims to summarize recent findings on the properties of phytochemicals in the modulation of sirtuin activity, with a particular focus on biochemical aspects.”
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