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Fisetin (3,3',4',7-tetrahydroxyflavone)
Flavonoid with potent senolytic properties, may clear damaged cells and support healthy aging.
What the evidence says
Fisetin appears to help in 3 of 3 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality randomised trials published 2014–2026 with a typical study size of 40 participants.
Based on 55 studies · 9 RCTs · 3,613 total participants
Confidence
HighWhat the studies found
By outcome
Fisetin has an evidence score of 8/10 — strong evidence based on 55 indexed studies. Flavonoid with potent senolytic properties, may clear damaged cells and support healthy aging.
The commonly studied dose of Fisetin is 100-500mg (intermittent dosing for senolytic effect). Research points to an estimated optimal dose around 750mg, with a minimum effective dose near 250mg. Individual response varies — start low and adjust.
The best time to take Fisetin is with meals. Take it with food. Fisetin is a lipophilic flavonoid with extremely poor native bioavailability due to rapid glucuronidation and sulfation in the gut wall and liver.
Nicotinamide Riboside
Mostly mechanism / observationalA vitamin B3 precursor that efficiently raises cellular NAD+ levels, supporting energy metabolism, mitochondrial function, and healthy aging.
Alpha Lipoic Acid
Likely helpsUniversal antioxidant that works in both water and fat, supporting blood sugar control, nerve health, and cellular energy.
Last reviewed May 2026 · evidence from 39 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Fisetin is a flavonoid found in strawberries, apples, and other plants. It's gained significant attention in longevity research as a potent senolytic — a compound that selectively eliminates senescent (damaged, 'zombie') cells that accumulate with age and contribute to aging and disease. Animal studies show remarkable effects, and human trials are underway.
Selectively eliminates senescent cells
Neutralizes free radicals
Reduces inflammatory signaling
How Fisetin works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
100-500mg (intermittent dosing for senolytic effect)
Loading: Some use 'senolytic dosing': 500-1500mg for 2 consecutive days, once monthly
Take with food
| Form | Type |
|---|---|
| 💊Fisetin capsules or powder | Recommended |
| 💊Liposomal fisetin | Alternative |
Bioavailability is limited. Enhanced forms may improve absorption.
Minimum: 4 weeks
Optimal: weeks
Cycling: For senolytic effect: some researchers suggest 2-3 days of high-dose (500-1500mg) monthly or quarterly. Daily low-dose use is also studied.
Note: Fat improves absorption. For senolytic purposes, intermittent high-dose protocols are sometimes used.
Based primarily on one RCT with exercise intervention (n=60) and systematic reviews without dose-specific data. Long-term safety unclear. Bioavailability highly dependent on formulation - standard fisetin has poor absorption.
Reduces burden of damaged cells
Lower inflammatory markers
Avoid — affects cellular processes
Consult oncologist — senolytics may have complex effects
May have antiplatelet effects — may affect platelet aggregation or vitamin K-dependent clotting factors, altering anticoagulant efficacy
Tip: Take with food
Fisetin is generally safe at recommended doses, with a few precautions worth noting. The most commonly reported side effects are GI upset. Use caution if any of these apply to you: Pregnancy (affects cell processes).
Resveratrol
Likely helpsPolyphenol found in red wine and grapes, studied for its potential anti-aging and cardiovascular benefits through sirtuin activation.
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