1Meta-Analysis2020
Hadi A, Askarpour M, Salamat S, Ghaedi E, Symonds ME, Miraghajani M · Pharmacol Res (2020)
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153 peer-reviewed studies
What the evidence says
Most Flaxseed studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1999–2026 with a typical study size of 68 participants.
Based on 153 studies · 25 meta-analyses · 120 RCTs · 4,471 total participants
Confidence
High confidenceBy outcome
48 studies in the last 5 years · Latest meta-analysis: 2026
Hadi A, Askarpour M, Salamat S, Ghaedi E, Symonds ME, Miraghajani M · Pharmacol Res (2020)
Hadi A, Askarpour M, Ziaei R, Venkatakrishnan K, Ghaedi E, Ghavami A · Phytother Res (2020)
Villarreal-Renteria AI, Herrera-Echauri DD, Rodríguez-Rocha NP, Zuñiga LY, Muñoz-Valle JF, García-Arellano S · Complement Ther Med (2022)
Ren GY, Chen CY, Chen GC, Chen WG, Pan A, Pan CW · Nutrients (2016)
Li L, Li H, Gao Y, Vafaei S, Zhang X, Yang M · Food Funct (2023)
Askarpour M, Karimi M, Hadi A, Ghaedi E, Symonds ME, Miraghajani M · Cytokine (2020)
Mohammadi-Sartang M, Mazloom Z, Raeisi-Dehkordi H, Barati-Boldaji R, Bellissimo N, Totosy de Zepetnek JO · Obes Rev (2017)
Rahimlou M, Jahromi NB, Hasanyani N, Ahmadi AR · Adv Nutr (2019)
Mohammadi-Sartang M, Sohrabi Z, Barati-Boldaji R, Raeisi-Dehkordi H, Mazloom Z · Nutr Rev (2018)
Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M · Clin Nutr (2016)
Pan A, Yu D, Demark-Wahnefried W, Franco OH, Lin X · Am J Clin Nutr (2009)
Błaszczuk A, Barańska A, Kanadys W, Malm M, Jach ME, Religioni U · Nutrients (2022)
Xi H, Zhou W, Sohaib M, Niu Y, Zhu R, Guo Y · Nutr Res (2023)
Jalili C, Pezeshki M, Askarpour M, Marx W, Hassani B, Hadi A · Phytother Res (2020)
Sadat Masjedi M, Mohammadi Pour P, Shokoohinia Y, Asgary S · Curr Probl Cardiol (2022)
Sahebkar A, Katsiki N, Ward N, Reiner Ž · Altern Ther Health Med (2021)
Khalesi S, Irwin C, Schubert M · J Nutr (2015)
Flower G, Fritz H, Balneaves LG, Verma S, Skidmore B, Fernandes R · Integr Cancer Ther (2014)
Shim YY, Kim JH, Cho JY, Reaney MJT · Crit Rev Food Sci Nutr (2024)
In plain English: Meanwhile, the effect of flaxseed oil intervention on waist circumstance, mood, and cognition need more human trials to determine.
Nie Y, Wang Y, Hui J, Shao D, Chen R, Deng Q, Chen Y, Wang X, Zhu D. · Nutrients (2025)