1RCT1987
Manni A, Santen RJ, Boucher AE, Lipton A, Harvey H, Simmonds M · J Steroid Biochem (1987)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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16 peer-reviewed studies
What the evidence says
Most Fluoxymesterone (Halotestin) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality randomised trials published 1974–2016.
Based on 16 studies · 11 RCTs
Confidence
Moderate confidenceBy outcome
Newest study from 2016
Manni A, Santen RJ, Boucher AE, Lipton A, Harvey H, Simmonds M · J Steroid Biochem (1987)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Champlin RE, Ho WG, Feig SA, Winston DJ, Lenarsky C, Gale RP · Blood (1985)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ingle JN, Twito DI, Schaid DJ, Cullinan SA, Krook JE, Mailliard JA · J Clin Oncol (1988)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Westerberg H · Cancer Treat Rep (1980)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ingle JN, Twito DI, Schaid DJ, Cullinan SA, Krook JE, Mailliard JA · Cancer (1991)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Tormey DC, Lippman ME, Edwards BK, Cassidy JG · Ann Intern Med (1983)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Sledge GW, Hu P, Falkson G, Tormey D, Abeloff M · J Clin Oncol (2000)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Manni A, Santen RJ, Boucher AE, Lipton A, Harvey H, Simmonds M · J Urol (1986)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Loprinzi CL, Kugler JW, Sloan JA, Mailliard JA, Krook JE, Wilwerding MB · J Clin Oncol (1999)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ingle JN, Suman VJ, Mailliard JA, Kugler JW, Krook JE, Michalak JC · Breast Cancer Res Treat (2006)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Brubaker LH, Brière J, Laszlo J, Kraut E, Landaw SA, Peterson P · Arch Intern Med (1982)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: Peliosis hepatis was found in 12 patients treated with high-dose oral oxymetholone or fluoxymesterone therapy; in three patients the lesion contributed to fatal hepatic failure, and in one biopsy-confirmed case the lesion regressed after the drug was withdrawn.
Nadell J, Kosek J. · Archives of Pathology & Laboratory Medicine (1977)
In plain English: Among 103 patients ... the median progression-free survival was 3.9 months (95% CI 3.2-5.3 months) and the clinical benefit rate was 43% ... fluoxymesterone remains a treatment option in heavily pretreated hormone receptor-positive metastatic breast cancer.
Kono M, Fujii T, Lyons GR, Huo L, Bassett R, Gong Y, Karuturi MS, Tripathy D, Ueno NT. · Breast Cancer Research and Treatment (2016)
In plain English: The 17 alpha-alkylated steroids (methyltestosterone, oxymetholone, and stanozolol) are directly toxic to hepatocytes ... whereas the nonalkylated steroids were not, supporting the role of 17 alpha-alkylation in anabolic-steroid hepatotoxicity.
Welder AA, Robertson JW, Melchert RB. · Journal of Pharmacological and Toxicological Methods (1995)
In plain English: In men who did not recover spontaneously, sequential treatments were given; only the androgen produced acceptable results and then only at unusually high doses, suggesting androgen insensitivity in these patients.
Van Thiel DH, Gavaler JS, Sanghvi A. · Gastroenterology (1983)
In plain English: Long-term preventive management with the synthetic androgens fluoxymesterone and oxymetholone reduced the frequency and severity of attacks in severely affected patients with hereditary angioedema.
Davis PJ, Davis FB, Charache P. · The Johns Hopkins Medical Journal (1974)