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Ge9.0
Ginger Extract Research
Likely helpsHigh safety
45 peer-reviewed studies
What the evidence says
Likely helps
Ginger Extract appears to help in 7 of 7 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2009–2026 with a typical study size of 94 participants.
Based on 45 studies · 16 meta-analyses · 9 RCTs · 21,163 total participants
Confidence
High
What the studies found
7helped· 38 more without graded effect data
By outcome
InflammationReduced nausea and improved digestion · 30-60 minutes (acute)
Likely helps19 studies
Safety profile
Mostly mechanism / observational9 studies
Women's healthMay help reduce menstrual discomfort and PMS symptoms · 1-3 cycles · Provides essential nutrients for healthy pregnancy · Ongoing
2Dysmenorrhoea symptomsMeta-AnalysisCited 69×n=3,101 · very large study2016
There is no high quality evidence to support the effectiveness of any dietary supplement for dysmenorrhoea, and evidence of safety is lacking.
Pattanittum P et al. · The Cochrane database of systematic reviews (2016)
Supplements versus other supplementsThere was no evidence of a difference in effectiveness between ginger and zinc sulphate (MD 0.02 points, 95% CI -0.58 to 0.62; one RCT, 101 women).
Vitamin B1 may be more effective than fish oil (MD -1.59 points, 95% CI -2.25 to -0.93; one RCT, 120 women).
There is no high quality evidence to support the effectiveness of any dietary supplement for dysmenorrhoea, and evidence of safety is lacking.
4Inflammatory markersMeta-AnalysisCited 50×n=1,010 · large study2020
Standard mean differences and 95% confidence intervals were calculated for net changes in inflammatory mediators using a random-effects model.
Morvaridzadeh M et al. · Cytokine (2020)
Huge benefit
← WorseNo effectBetter →
Standard mean differences and 95% confidence intervals were calculated for net changes in inflammatory mediators using a random-effects model.
There was a significant reduction of circulating CRP (SMD: -5.11, 95% CI: -7.91, -2.30, I2 = 98.1%), hs-CRP (SMD: -0.88, 95% CI: -1.63, -0.12, I2 = 90.8%) and TNF-α levels (SMD: -0.85, 95% CI: -1.48, -0.21, I2 = 89.4%) following ginger supplementation.
However, meta-analysis results did not show any significant impact of ginger supplementation on IL-6 (SMD: -0.45, 95% CI: -1.29, 0.38, I2 = 89.2%), and sICAM levels (SMD: -0.05, 95% CI: -0.36, 0.26, I2 = 00.0%).
6Gingivitis and periodontitis improvementSystematic ReviewCited 14×2025
Natural products, including single extracts and polyherbal formulations, provide effective and safe alternatives for managing gingivitis and PD.
Malcangi G et al. · Nutrients (2025)
Natural products, including single extracts and polyherbal formulations, provide effective and safe alternatives for managing gingivitis and PD.
Their anti-inflammatory, antimicrobial, and antioxidant properties support their adjunctive role alongside with scaling and root planning therapy (SRP) in periodontal therapy.
However, further large-scale, long-term studies are needed to standardize formulations and establish optimal protocols.
Therefore, ginger could be considered as an effective lipid lowering nutraceuticals.
Salih AK et al. · Phytotherapy research : PTR (2023)
Noticeable benefit
← WorseNo effectBetter →
Likely real
In terms of ginger dose, the result of meta-regression found to be significant only for TC, so that increasing daily doses of ginger reduces TC levels by (β: -0.67; 95% CI: -1.28, -0.07; p = 0.028).
Ginger supplementation decreased TG in obese and diabetic subjects more efficiently.
Therefore, ginger could be considered as an effective lipid lowering nutraceuticals.
9Pain intensity in primary dysmenorrheaMeta-AnalysisCited 2×n=24 · very small study2024
The findings are limited due to risk of bias in the included studies and the unclear risk-benefit ratio.
Moshfeghinia R et al. · Journal of integrative and complementary medicine (2024)
Huge benefit
← WorseNo effectBetter →
Random effects meta-analyses were performed to obtain standardized mean differences (SMD) and 95% confidence intervals (CI).
The combined results of the studies indicate that ginger is notably more effective than placebo in reducing both the intensity (SMD = -1.13; 95% CI = -1.59 to -0.68, I2 = 81.05%) and duration of pain (SMD = -0.29; 95% CI = -0.46 to -0.12).
There were no differences between ginger and nonsteroidal anti-inflammatory drugs (NSAIDs) (SMD = 0.01; 95% CI = -0.24 to 0.25), or exercise (SMD = 0.06; 95% CI = -0.66 to 0.78) for pain intensity.
10Glycemic control in type 2 diabetesMeta-AnalysisCited 3×2024
Currently published articles are still limited, requiring further studies of high methodological quality to verify the effectiveness of ginger supplementation on T2DM parameters control.
Schumacher JC et al. · Clinical nutrition ESPEN (2024)
However, individual studies reported mixed results, with two studies showing a significant reduction in FBS.
This suggests that while ginger may have potential as an adjuvant therapy, its overall impact on glycemic control in T2DM is not statistically significant when results are pooled.
Currently published articles are still limited, requiring further studies of high methodological quality to verify the effectiveness of ginger supplementation on T2DM parameters control.
This comprehensive review highlights the potential of herbal interventions as valuable adjuncts or alternatives for managing cardiovascular diseases.
Wal A et al. · Current cardiology reviews (2024)
This comprehensive review highlights the potential of herbal interventions as valuable adjuncts or alternatives for managing cardiovascular diseases.
Herbal remedies offer diverse mechanisms of action, targeting key CVD risk factors and pathways.
While promising, their clinical utility warrants further investigation through well-designed trials to establish their safety and efficacy, paving the way for integrated approaches to cardiovascular disease management.
Dietary consumption of ginger appears safe and may exert beneficial effects on human health and well-being, with greatest confidence in antiemetic effects in pregnant women, analgesic effects in osteoarthritis, and glycemic control.
Crichton M et al. · The American journal of clinical nutrition (2022)
Twenty-four systematic reviews were included with 3% overlap of primary studies.
The strongest evidence was found for the antiemetic effects of ginger in pregnant women (effect size: large; GRADE: high), analgesic effects for osteoarthritis (effect size: small; GRADE: high), and glycemic control (effect size: none to very large; GRADE: very low to moderate).
Future randomized controlled and dose-dependent trials with adequate sample sizes and standardized ginger products are warranted to better inform and standardize routine clinical prescription.
However, future clinical trials are essential to investigate the clinical application of ginger in this area.
Samadi M et al. · Phytotherapy research : PTR (2022)
Eighteen eligible studies were identified, including 17 in-vivo experiments in quantitative analysis and 3 clinical trials in qualitative analysis.
Ginger administration may reduce many clinical aspects of FLD by several mechanisms, including insulin-sensitive effects, stimulating the expression of antioxidant enzymes, reducing the generation of reactive oxygen species (ROS), having antidyslipidemic activities, and reducing hepatic fat content.
However, future clinical trials are essential to investigate the clinical application of ginger in this area.
15Health beneficial effects of ginger compoundsSystematic ReviewCited 127×2021
This review provides an up-to-date understanding of the scientific evidence on the development of ginger and its active compounds as health beneficial agents in future clinical trials.
Zhang M et al. · Phytotherapy research : PTR (2021)
In addition, gingerol analogues such as 6-gingerol and 6-shogaol can be rapidly eliminated in the serum and detected as glucuronide and sulfate conjugates.
Structural variation would be useful to improve the metabolic characteristics and bioactivities of lead compounds derived from ginger.
Furthermore, some clinical trials have indicated that ginger can be consumed for attenuating nausea and vomiting during early pregnancy; however, there is not sufficient data available to rule out its potential toxicity, which should be monitored especially over longer periods.
16Blood lipids and body weightMeta-AnalysisCited 2×2022
The present meta-analysis and review revealed that ginger supplementation can improve lipid profile and body weight if used at the appropriate dose and duration.
Asghari-Jafarabadi M et al. · Current pharmaceutical design (2022)
Noticeable benefit
← WorseNo effectBetter →
The results showed that ginger consumption could significantly improve lipid profile including total triglyceride (-12.54 (-20.01 to -5.08)), cholesterol (-6.53 (-10.76 to -2.31)), LDL (-5.14 (-8.79 to -1.50)), and HDL (1.13 (0.35 to 1.91)).
Moreover, ginger supplementation could significantly decrease body mass index (BMI) (-0.49 (-0.79 to -0.18)).
However, the small number of sample studies that investigated reductions in body weight (-0.52 (-1.48 to 0.43)) were not statistically significant.
Furthermore, the pharmacology of gut microbiota-related gastrointestinal benefits has also been discussed in order to explore better ways to prevent and treat gastrointestinal disorders, which can be used as a reference for further research.
Lai W et al. · The American journal of Chinese medicine (2022)
Previous researches mainly focused on the differences in chemical composition between them, but there was no systematical comparison on the similarity concerning research achievements of the two herbs.
Meanwhile, ginger has traditionally been used for the treatment of gastrointestinal disorders, but so far, the possible interaction with human gut microbiota has hardly been considered.
This review comprehensively presents similarities and differences between SJ and GJ retrospectively, particularly proposing them the significant differences in botany, phytochemistry and ethnopharmacology, which can be used as evidence for clinical application of SJ and GJ.
18Encapsulation of ginger bioactive compoundsSystematic ReviewCited 10×2022
The potential use of encapsulated GBCs as a promising active ingredient to be applied in different food products is discussed in detail.
Tavares L et al. · Food & function (2022)
However, these bioactive compounds are unstable and susceptible to degradation, volatilization and oxidation during extraction and processing, mainly owing to their exposure to environments with adverse conditions, such as high temperature, the presence of O2 and light.
This work summarizes the fundamental principles of, recent progress in and effectiveness of different methods regarding the physicochemical, structural and functional properties of encapsulated GBCs.
The potential use of encapsulated GBCs as a promising active ingredient to be applied in different food products is discussed in detail.
19Dyslipidaemia, blood pressure, and inflammationSystematic ReviewCited 5×n=24 · very small study2022
Although there remains a paucity of studies, Z. officinale may be beneficial for improving dyslipidaemia and inflammation.
Daniels CC et al. · Clinical nutrition ESPEN (2022)
A total of 24 studies were included, mostly (79.2%) showing low risk of bias.
These were based on obesity and cardio-metabolic derangements (33.3%), type 2 diabetes mellitus (37.5%), and miscellaneous conditions (29.2%).
Inflammatory markers (CRP, TNF-α) were more consistently reduced by Z. officinale, while only 3 studies reported a non-significant reduction of blood pressure.
20Body weight and obesity parametersSystematic ReviewCited 54×2018
This review article provides some convincing evidence to support the efficacy of ginger in obesity management and demonstrates the importance of future clinical trials.
Ebrahimzadeh Attari V et al. · Phytotherapy research : PTR (2018)
Twenty-seven articles (6 in vitro, 17 animal, and 4 human studies) were reviewed.
Most of the experimental studies supported the weight lowering effect of ginger extract or powder in obese animal models, whereas the results of the available limited clinical studies showed no changes or slight changes of anthropometric measurements and body composition in subjects with obesity.
Ginger could modulate obesity through various potential mechanisms including increasing thermogenesis, increasing lipolysis, suppression of lipogenesis, inhibition of intestinal fat absorption, and controlling appetite.