Gse7.5

Grape Seed Extract

botanical

Grape Seed Extract (OPCs)

Rich source of oligomeric proanthocyanidins (OPCs) that support circulation, skin health, and antioxidant defense.

immunityantioxidantOPCscirculationskin health

38+ studies

Evidence

Reviewed 19 days ago

high

Safety

100-300mg (standardized to 95% OPCs)

Dose

4-12 weeks

Time to Effect

Standardized extract (95% OPCs or proanthocyanidins)

Best Form

Grape Seed Extract is rich in oligomeric proanthocyanidins (OPCs), powerful antioxidants that support blood vessel health, reduce oxidative stress, and support skin collagen. Research shows benefits for circulation, blood pressure, chronic venous insufficiency, and skin aging. One of the most potent antioxidant supplements available.

Mechanisms of Action

🛡️

OPC Antioxidant Activity

Among the most powerful natural antioxidants

🔄

Vascular Support

Strengthens blood vessel walls

✨

Collagen Protection

Protects and supports skin collagen

Biological PathwayBeta

How Grape Seed Extract works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.

Recommended Dose

100-300mg (standardized to 95% OPCs)

100mg600mg

Optimal Timing

With meals

Take with food

Available Forms

Form	Type
💊Standardized extract (95% OPCs or proanthocyanidins)	Recommended
💊Combined with resveratrol or pine bark	Alternative

Look for extracts standardized to OPC content. Quality varies between products.

Duration

Minimum: 4 weeks

Optimal: 12 weeks

Cycling: Not required

Note: Can be taken any time of day with food.

🔄

Improved Circulation

Better blood flow and reduced leg swelling

⏱️ 4-8 weeks

60% of users notice thispositive

📉

Blood Pressure Reduction

Modest decrease in blood pressure

⏱️ 8-12 weeks

50% of users notice thispositive

✨

Skin Health

Improved skin elasticity and appearance

⏱️ 8-12 weeks

50% of users notice thispositive

High SafetyMax safe dose: Up to 600mg/day used in studies

🟡

Pregnant/nursing

Insufficient data; consult doctor

Who Should NOT Take This

Grape allergy

Drug Interactions

Blood thinnersmild

May have mild antiplatelet effects — may affect platelet aggregation or vitamin K-dependent clotting factors, altering anticoagulant efficacy

Blood pressure medicationsmild

May have additive blood pressure lowering

Possible Side Effects

Headache

milduncommon

Tip: Usually resolves

GI upset

mildrare

Tip: Take with food

Dizziness

mildrare

Tip: May indicate blood pressure reduction

Warnings

May affect blood clotting — use caution before surgery
Quality varies — choose standardized extracts

✦ Vitamin C

enhances

OPCs regenerate vitamin C

Enhanced and prolonged antioxidant protection

⟡ Pycnogenol

complementary

Similar OPC compounds from different source

Comprehensive OPC coverage

Top studies from 38+ peer-reviewed papers

📚meta-analysisn=7690

DOI

Martinez-Zapata MJ et al. • The Cochrane database of systematic reviews (2020)

“There is moderate-certainty evidence that phlebotonics probably reduce oedema slightly, compared to placebo; moderate-certainty evidence of little or no difference in QoL; and low-certainty evidence that these drugs do not influence ulcer healing.”

Key Findings:

Pooled data suggest that phlebotonics probably increase adverse events slightly, compared to placebo (RR 1.14, 95% CI 1.02 to 1.27; 37 studies; 5789 participants; moderate-certainty evidence).
There is moderate-certainty evidence that phlebotonics probably reduce oedema slightly, compared to placebo; moderate-certainty evidence of little or no difference in QoL; and low-certainty evidence that these drugs do not influence ulcer healing.
Moderate-certainty evidence suggests that phlebotonics are probably associated with a higher risk of adverse events than placebo.
Studies included in this systematic review provided only short-term safety data; therefore, the medium- and long-term safety of phlebotonics could not be estimated.

📚meta-analysisn=1284

DOI

Goudarzi MA et al. • Current drug targets (2024)

“Our study suggests that grape products intake may help to decrease body weight in obese participants.”

Key Findings:

The outcomes have revealed grape products intake to significantly decrease body weight (p = 0.001) and body mass index (p = 0.004) in obese participants, and also, a greater effect was observed when grape seed extract was used.
Our study suggests that grape products intake may help to decrease body weight in obese participants.
Future large RCTs with longer duration and obese populations are needed to expand our findings.

📚systematic-review

DOI

GBD 2019 Lip, Oral, and Pharyngeal Cancer Collaborators et al. • JAMA oncology (2023)

“In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use.”

Key Findings:

In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use.
These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts.
Further research warranted to confirm findings

📊rctn=105

DOI

Angelopoulos N et al. • Nutrients (2023)

“Our results confirm the LDL-C-lowering properties of monacolin are clinically meaningful even in lower doses of 3 mg/day.”

Key Findings:

LDL-C decreased by 26.46% on average (p < 0.001) during treatment with 10 mg of monacolin and by 16.77% on average during treatment with 3 mg of monacolin (p < 0.001).
We observed a slight but significant reduction of the triglyceride levels only in the high-dose-treated group (mean -4.25%; 95% CI of mean -11.11 to 2.61).
No severe adverse events occurred during the study.
Our results confirm the LDL-C-lowering properties of monacolin are clinically meaningful even in lower doses of 3 mg/day.

📊rctn=863

DOI

Wang TY et al. • NEJM evidence (2023)

“CONCLUSIONS: Apixaban did not demonstrate noninferiority to warfarin and is less effective than warfarin for the prevention of valve thrombosis or thromboembolism in patients with an On-X mechanical aortic valve. (Funded by Artivion; ClinicalTrials.gov number, NCT04142658.)”

Key Findings:

Most (94%) participants took aspirin.
A total of 26 primary end-point events occurred, 20 (in 16 participants) in the apixaban group (4.2%/patient-year; 95% confidence interval [CI], 2.3 to 6.0) and 6 (in 6 participants) in the warfarin group (1.3%/patient-year; 95% CI, 0.3 to 2.3).
The difference in primary end-point rates between the apixaban and warfarin groups was 2.9 (95% CI, 0.8 to 5.0); noninferiority and OPC success criteria were not met.
Major bleeding rates were 3.6%/patient-year with apixaban and 4.5%/patient-year with warfarin.

View all 38+ studies

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Gse7.5

Grape Seed Extract

botanical

Grape Seed Extract (OPCs)

Rich source of oligomeric proanthocyanidins (OPCs) that support circulation, skin health, and antioxidant defense.

immunityantioxidantOPCscirculationskin health

38+ studies

Evidence

Reviewed 19 days ago

high

Safety

100-300mg (standardized to 95% OPCs)

Dose

4-12 weeks

Time to Effect

Standardized extract (95% OPCs or proanthocyanidins)

Best Form

Mechanisms of Action

🛡️

OPC Antioxidant Activity

Among the most powerful natural antioxidants

🔄

Vascular Support

Strengthens blood vessel walls

✨

Collagen Protection

Protects and supports skin collagen

Biological PathwayBeta

How Grape Seed Extract works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.

Supplement

Molecular Target

Biological Process

Health Outcome

Strong

Moderate

Emerging

strong

moderate

emerging

Tap node to isolate • Pinch to zoom • Tap edge for research

Recommended Dose

100-300mg (standardized to 95% OPCs)

100mg600mg

Optimal Timing

With meals

Take with food

Available Forms

Form	Type
💊Standardized extract (95% OPCs or proanthocyanidins)	Recommended
💊Combined with resveratrol or pine bark	Alternative

Look for extracts standardized to OPC content. Quality varies between products.

Duration

Minimum: 4 weeks

Optimal: 12 weeks

Cycling: Not required

Note: Can be taken any time of day with food.

🔄

Improved Circulation

Better blood flow and reduced leg swelling

⏱️ 4-8 weeks

60% of users notice thispositive

📉

Blood Pressure Reduction

Modest decrease in blood pressure

⏱️ 8-12 weeks

50% of users notice thispositive

✨

Skin Health

Improved skin elasticity and appearance

⏱️ 8-12 weeks

50% of users notice thispositive

High SafetyMax safe dose: Up to 600mg/day used in studies

🟡

Pregnant/nursing

Insufficient data; consult doctor

Who Should NOT Take This

Grape allergy

Drug Interactions

Blood thinnersmild

May have mild antiplatelet effects — may affect platelet aggregation or vitamin K-dependent clotting factors, altering anticoagulant efficacy

Blood pressure medicationsmild

May have additive blood pressure lowering

Possible Side Effects

Headache

milduncommon

Tip: Usually resolves

GI upset

mildrare

Tip: Take with food

Dizziness

mildrare

Tip: May indicate blood pressure reduction

Warnings

May affect blood clotting — use caution before surgery
Quality varies — choose standardized extracts

✦ Vitamin C

enhances

OPCs regenerate vitamin C

Enhanced and prolonged antioxidant protection

⟡ Pycnogenol

complementary

Similar OPC compounds from different source

Comprehensive OPC coverage

Top studies from 38+ peer-reviewed papers

📚meta-analysisn=7690

DOI

Martinez-Zapata MJ et al. • The Cochrane database of systematic reviews (2020)

“There is moderate-certainty evidence that phlebotonics probably reduce oedema slightly, compared to placebo; moderate-certainty evidence of little or no difference in QoL; and low-certainty evidence that these drugs do not influence ulcer healing.”

Key Findings:

Pooled data suggest that phlebotonics probably increase adverse events slightly, compared to placebo (RR 1.14, 95% CI 1.02 to 1.27; 37 studies; 5789 participants; moderate-certainty evidence).
There is moderate-certainty evidence that phlebotonics probably reduce oedema slightly, compared to placebo; moderate-certainty evidence of little or no difference in QoL; and low-certainty evidence that these drugs do not influence ulcer healing.
Moderate-certainty evidence suggests that phlebotonics are probably associated with a higher risk of adverse events than placebo.
Studies included in this systematic review provided only short-term safety data; therefore, the medium- and long-term safety of phlebotonics could not be estimated.

📚meta-analysisn=1284

DOI

Goudarzi MA et al. • Current drug targets (2024)

“Our study suggests that grape products intake may help to decrease body weight in obese participants.”

Key Findings:

The outcomes have revealed grape products intake to significantly decrease body weight (p = 0.001) and body mass index (p = 0.004) in obese participants, and also, a greater effect was observed when grape seed extract was used.
Our study suggests that grape products intake may help to decrease body weight in obese participants.
Future large RCTs with longer duration and obese populations are needed to expand our findings.

📚systematic-review

DOI

GBD 2019 Lip, Oral, and Pharyngeal Cancer Collaborators et al. • JAMA oncology (2023)

“In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use.”

Key Findings:

In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use.
These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts.
Further research warranted to confirm findings

📊rctn=105

DOI

Angelopoulos N et al. • Nutrients (2023)

“Our results confirm the LDL-C-lowering properties of monacolin are clinically meaningful even in lower doses of 3 mg/day.”

Key Findings:

LDL-C decreased by 26.46% on average (p < 0.001) during treatment with 10 mg of monacolin and by 16.77% on average during treatment with 3 mg of monacolin (p < 0.001).
We observed a slight but significant reduction of the triglyceride levels only in the high-dose-treated group (mean -4.25%; 95% CI of mean -11.11 to 2.61).
No severe adverse events occurred during the study.
Our results confirm the LDL-C-lowering properties of monacolin are clinically meaningful even in lower doses of 3 mg/day.

📊rctn=863

DOI

Wang TY et al. • NEJM evidence (2023)

“CONCLUSIONS: Apixaban did not demonstrate noninferiority to warfarin and is less effective than warfarin for the prevention of valve thrombosis or thromboembolism in patients with an On-X mechanical aortic valve. (Funded by Artivion; ClinicalTrials.gov number, NCT04142658.)”

Key Findings:

Most (94%) participants took aspirin.
A total of 26 primary end-point events occurred, 20 (in 16 participants) in the apixaban group (4.2%/patient-year; 95% confidence interval [CI], 2.3 to 6.0) and 6 (in 6 participants) in the warfarin group (1.3%/patient-year; 95% CI, 0.3 to 2.3).
The difference in primary end-point rates between the apixaban and warfarin groups was 2.9 (95% CI, 0.8 to 5.0); noninferiority and OPC success criteria were not met.
Major bleeding rates were 3.6%/patient-year with apixaban and 4.5%/patient-year with warfarin.

View all 38+ studies

What would you like to do next?

Compare with Others Find Based on Your Goals

Related Supplements

Asx7.5

Astaxanthin

7.5/10

Carotenoid from algae that spans cell membranes for full-spectrum protection — studied for skin, eye health, and exercise recovery.

Age9.0

Aged Garlic Extract

9/10

Odorless garlic extract with strong evidence for cardiovascular health, blood pressure, and immune support.

Cur9.0

Curcumin

9/10

Turmeric's active compound that modulates NF-kB inflammatory pathways — supports mood, joint health, and post-exercise recovery.

Gte9.0

Green Tea Extract

9/10

Concentrated catechins from green tea that support metabolism, fat oxidation, brain health, and antioxidant defense.