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Gua3.0
Guarana Research
Mostly mechanism / observational
23 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Guarana studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2006–2026 with a typical study size of 2,062 participants.
Based on 23 studies · 4 meta-analyses · 15 RCTs · 2,082 total participants
Confidence
High confidence
By outcome
Energy & fatigueReliable caffeine-driven energy; a meta-analysis supports reduced cancer-related fatigue specifically · 30-60 minutes
Mostly mechanism / observational8 studies
Safety profile
Too few graded studies1 study
Active research area
13 studies in the last 5 years · Latest meta-analysis: 2024
200620162026
1Meta-Analysis2024
Maselli-Schoueri JH, Aguiar Junior PN, Giglio AD · Rev Assoc Med Bras (1992) (2024)
Wang L, Xu X, Guo M, Dong Y, Ding H, Hao S, Huo L, Song Y, Gu J, Yu Z. · Frontiers in pharmacology (2025)
Moreover, Withania somnifera was found to be the most promising option for reducing fatigue (99.9%), pain (100.0%), and nausea (98.6%).
Conclusion The network meta-analysis indicates that Withania somnifera was effective in enhancing quality of life and contributed to a reduction in therapeutic side effects in BC patients.
Our findings support the therapeutic potential of plant bioactive substances in breast cancer care; however, further clinical validation of their efficacy is warranted.
In plain English: Well-designed, multicenter trials are essential to determine whether phytotherapy can meaningfully contribute to CRF management.
Matsas S, Medeiros Araujo de Matos U, Molina Llata C, Del Giglio A. · Diseases (Basel, Switzerland) (2026)
Standardized mean differences (SMDs) were pooled using a DerSimonian-Laird random-effects model.
Overall, phytotherapy provided a modest improvement in CRF (SMD = 0.31; 95% CI, 0.08-0.53; p = 0.022), though heterogeneity was substantial (I 2 = 56.7%).
In subgroup analyses, only the group of "other formulations" demonstrated significant benefit; ginseng and guaraná did not demonstrate statistically significant effects.
In plain English: Excessive EDs consumption poses a real cardiotoxic risk, especially in vulnerable populations, underscoring the need for further human research and potential regulatory consideration.
Ghamlouch A, Di Fazio N, Racciatti M, Del Duca F, Treves B, De Angelis G, De Matteis A, Maiese A, Frati P. · Cardiovascular toxicology (2025)
Notably, similarities between EDs and cocaine emerged, including shared mechanisms involving ion channel blockade, sympathetic overactivation, vasoconstriction, and prothrombotic states.
Chronic use of either substance can result in structural heart damage and remodelling.
Although EDs and cocaine differ in legal status and potency, their overlapping cardiovascular effects warrant greater clinical awareness and public education.
In plain English: Conclusion Acute ingestion of guarana improves the capacity to perform intermittent exercise in soccer players but seems to be ineffective to improve lower limb power, sprint, and agility.
Estrázulas JA, Pereira Dos Santos F, Taborda Machado AJ, Legnani E, Bertuzzi R, Lima-Silva AE. · Journal of the American Nutrition Association (2024)
However, guarana ingestion increased the distance covered in the YYIR1, compared with placebo ingestion ( p = 0.01).
The battery of tests included a countermovement jump test, sprints of 10 and 20 m, an Illinois agility test, and a Yo-Yo Intermittent Recovery Test level 1 (YYIR1).
Results Guarana ingestion did not improve countermovement jump, sprints, or agility ( p > 0.05).