Gg7.5

Guggul Research

39 peer-reviewed studies · Evidence score: 7.5/10

A Systematic Review and Meta-Analysis of Ayurvedic Herbal Preparations for Hypercholesterolemia

Gyawali D et al. • Medicina (Kaunas, Lithuania) (2021)

In addition, minimal evidence was found for any side effects associated with these herbs, positioning them as safe adjuvants to conventional treatments.

Meta-analysis of the trials showed that guggulu reduced total cholesterol and low-density lipoprotein levels by 16.78 mg/dL (95% C.I. 13.96 to 2.61; p-value = 0.02) and 18.78 mg/dL (95% C.I. 34.07 to 3.48; p = 0.02), respectively.
Garlic reduced LDL-C by 10.37 mg/dL (95% C.I. -17.58 to -3.16; p-value = 0.005).
Black cumin lowered total cholesterol by 9.28 mg/dL (95% C.I. -17.36, to -1.19, p-value = 0.02).

Meta-Analysisn=1,386

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Current stage of preclinical and clinical development of guggulsterone in cancers: Challenges and promises

Ijaz S et al. • Cell biology international (2024)

This comprehensive review provides a foundation for ongoing research, offering insights into the potential of GS as a valuable addition to the armamentarium against cancer.

The review synthesizes evidence from diverse studies, underscoring the multifaceted biological activities of GS in cancer prevention and treatment.
To advance our understanding, future clinical and translational studies are imperative to determine effective doses in humans.
Additionally, there is a need for the development of new pharmaceutical forms of GS to optimize therapeutic effects.

Systematic Review

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The Potential of Natural Products in the Management of Cardiovascular Disease

Singhai H et al. • Current pharmaceutical design (2024)

Some natural products with potential in the management of cardiovascular diseases such as Allium sativum L., Ginkgo biloba, Cinchona ledgeriana, Ginseng, Commiphora mukul, Digitalis lanata, Digitalis purpurea L., Murrayakoenigii, Glycyrrhiza glabra, Polygonum cuspidatum, Fenugreek, Capsicum annuum, etc. are discussed in this article.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

This potentiates the use of medicinal plants, which are still a viable alternative therapy for a number of diseases, including CVD.
Natural products' cardio-protective effects result from their anti-oxidative, anti-hypercholesterolemia, anti-ischemic, and platelet aggregation-inhibiting properties.
The conventional therapies used to treat CVD have the potential to be explored in light of the recent increase in the popularity of natural goods and alternative medicine.

Systematic Review

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Exploring the Promising Role of Guggulipid in Rheumatoid Arthritis Management: An In-depth Analysis

Sahu A et al. • Current rheumatology reviews (2024)

This review provides a deeper understanding of the therapeutic mechanisms and potential of guggulipid in the management of rheumatoid arthritis.

This review provides a deeper understanding of the therapeutic mechanisms and potential of guggulipid in the management of rheumatoid arthritis.
The collective evidence strongly supports the promising role of guggulipid as a therapeutic agent, encouraging further research and development in guggulipid-based treatments for these conditions.
Further research warranted to confirm findings

Systematic Review

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Supplements for Lipid Lowering: What Does the Evidence Show?

Mirzai S et al. • Current cardiology reports (2023)

Patients should be educated on the difference between these DSs and evidence-based lipid-lowering medications proven to improve cardiovascular outcomes.

Systematic review examining Guggul efficacy
Further research warranted to confirm findings

Systematic Review

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Commiphora mukul (Hook. ex Stocks) Engl.: Historical records, application rules, phytochemistry, pharmacology, clinical research, and adverse reaction

Garang Z et al. • Journal of ethnopharmacology (2023)

As an essential traditional medicine, C. mukul is widely used in the national traditional medicine system, and rich in chemical constituents and exhibit pharmacological activities.

As an essential traditional medicine, C. mukul is widely used in the national traditional medicine system, and rich in chemical constituents and exhibit pharmacological activities.
This study found that current research on C. mukul mainly focuses on its chemical composition and pharmacological properties.
However, scientific research on the quality control of medicinal materials, identification of original plants, pharmacokinetics, and toxicology are relatively weak, and research in this area needs to be strengthened.

Systematic Review

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A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview

Maideen NMP et al. • Current drug metabolism (2021)

The prescribers and the pharmacists are needed to be aware of the drugs interacting with β-blockers to prevent possible adverse drug interactions.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

John's wort and Yohimbine.
This article focuses on clinically relevant drug interactions of β-blockers with commonly prescribed medications.
In addition to Pharmacokinetics and Pharmacodynamics of the drug interactions, recommendations for clinical practice are highlighted.

Systematic Review

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Pharmacological Uses of the Plants Belonging to the Genus Commiphora

Latha S et al. • Cardiovascular & hematological agents in medicinal chemistry (2021)

This review indicates the necessity of further in-depth research, pre-clinical, and clinical studies with Commiphora genus, which may help to detect the unidentified potential of the Commiphora plant species.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Furthermore, the review also included various secondary metabolites isolated from various species of Commiphora genus along with their chemical structures serving as a ready resource for researchers.
We conclude that the plant species belonging to the genus Commiphora possesses abundant pharmacological properties with a huge treasure of diverse secondary metabolites within themselves.
Further research warranted to confirm findings

Systematic Review

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An Evidence-based Review of Medicinal Plants used in Traditional Persian Medicine for Treatment of Osteoarthritis

Karami S et al. • Current drug discovery technologies (2021)

Medicinal plants seem to be a valuable source for discovering and identifying new drugs for treatment of OA; however, since most of the studies are preclinical, further clinical trials are required to achieve more conclusive results.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

The prevalence of this disease in adults over 60 years was 9.6% in men and 18% in women.
In this paper, different sources of Traditional Persian Medicine (TPM) were searched to obtain any evidence evaluating any medicinal plants in the management of OA.
The most important medicinal plants with direct evidence in the management of OA are Allium sativum, Commiphora mukul, Linum usitatissimum, Matricaria chamomilla, Nigella sativa, Zingiber officinale, and Piper nigrum.

Systematic Review

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Pharmacological properties of guggulsterones, the major active components of gum guggul

Shah R et al. • Phytotherapy research : PTR (2012)

This review highlights the taxonomic details, phytochemical properties and pharmacological profile of gum guggul.

Its active constituents, the Z- and E-guggulsterones, have been demonstrated to exhibit their biological activities by binding to nuclear receptors and modulating the expression of proteins involved in carcinogenic activities.
Considerable scientific evidence indicates the use of gum guggul as a therapeutic agent in the treatment of inflammation, nervous disorders, hyperlipidaemia and associated cardiac disorders such as hypertension and ischaemia, skin disorders, cancer and urinary disorders.
This review highlights the taxonomic details, phytochemical properties and pharmacological profile of gum guggul.

Systematic Review

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Guggulipid: A Promising Multi-Purpose Herbal Medicinal Agent

Ahmad MA et al. • Drug research (2020)

Graphical Abstract Graphical Abstract.© Georg Thieme Verlag KG Stuttgart · New York.

Guggul has been used for thousands of years in the treatment of arthritis, inflammation, obesity, cardiac protection, anti-ulcer, anti-epileptic and disorders of lipid metabolism.
This review is an assortment of available information reported on its chemical, pharmacological and toxicological properties in various research studies.
The available therapeutic properties of guggulipid make it suitable natural product for the treatment of various disorders like inflammation, pain, wounds, liver disorder and Acne etc.

Systematic Review

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Medicinal plants in treatment of hypertriglyceridemia: A review based on their mechanisms and effectiveness

Mollazadeh H et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2019)

It seems that use of these plants as complementary therapeutics or extraction of their active ingredients along with currently available drugs will improve the management of HTg in patients.

It seems that use of these plants as complementary therapeutics or extraction of their active ingredients along with currently available drugs will improve the management of HTg in patients.
Further research warranted to confirm findings

Systematic Review

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Traditional and modern aspects of hemorrhoid treatment in Iran: a review

Dehdari S et al. • Journal of integrative medicine (2018)

Among the mentioned herbal medicines, six species, including Allium ampeloprasum, Phyllanthus emblica, Aloe vera, Terminalia chebula, Vitis vinifera and Commiphora mukul, had the largest number of ...

Among the mentioned herbal medicines, six species, including Allium ampeloprasum, Phyllanthus emblica, Aloe vera, Terminalia chebula, Vitis vinifera and Commiphora mukul, had the largest number of related pharmacological effects documented in scientific databases.
These herbs from ITM should be considered as important resources for producing novel drugs for hemorrhoid treatment.

Systematic Review

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Medicinal plants with traditional use: Ethnobotany in the Indian subcontinent

Rupani R et al. • Clinics in dermatology (2018)

In developing countries, the majority of people rely on traditional medicines; however, many of these practices have not been rigorously and systematically studied or reported.

In developing countries, the majority of people rely on traditional medicines; however, many of these practices have not been rigorously and systematically studied or reported.
We review the current understanding and research behind traditional therapies prevalent in the Indian subcontinent, including mind-body and energy-based healing, botanical medicine, and herbal remedies.
Topics covered include Ayurveda, yoga, naturopathy, Unani, Siddha, Sowa-Rigpa, homeopathy, and medicinal plants such as neem, guggul, tulsi, amla, and turmeric.

Systematic Review

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Guggulsterone for Chemoprevention of Cancer

Shishodia S et al. • Current pharmaceutical design (2016)

This review describes the anti-cancer properties, molecular targets, and the apoptotic effects of guggulsterone.

Guggulsterone modulates the expression of gene products involved in metastasis (MMP-9, COX-2, and VEGF) of tumor cells.
Guggulsterone mediates gene expression through the modulation of several transcription factors, including NF-κB, STAT3, C/EBPα, androgen receptor, and glucocorticoid receptors.
This review describes the anti-cancer properties, molecular targets, and the apoptotic effects of guggulsterone.

Systematic Review

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Guggulsterone and Its Role in Chronic Diseases

Yamada T et al. • Advances in experimental medicine and biology (2016)

This review aimed to clarify the cell signal pathways targeted by guggulsterone and the bioactivities of guggulsterone in animal models and humans.

This plant steroid has been reported to work as an antagonist of certain nuclear receptors, especially farnesoid X receptor, which regulates bile acids and cholesterol metabolism.
Guggulsterone also mediates gene expression through the regulation of transcription factors, including nuclear factor-kappa B and signal transducer and activator of transcription 3, which plays important roles in the development of inflammation and tumorigenesis.
Guggulsterone has been shown to downregulate the expression of proteins involved in anti-apoptotic, cell survival, cell proliferation, angiogenic, metastatic, and chemoresistant activities in tumor cells.

Systematic Review

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Traditional herbs: a remedy for cardiovascular disorders

Rastogi S et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2016)

Although the mechanisms of action are not very clear, there is enough evidence of their efficacy in various cardiovascular disorders.

Although the mechanisms of action are not very clear, there is enough evidence of their efficacy in various cardiovascular disorders.
However, for bringing more objectivity and also to confirm traditional claims, more systematic, well-designed animal and randomized clinical studies with sufficient sample sizes are necessary.
Multidisciplinary research is still required to exploit the vast potential of these plants.

Systematic Review

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Cancer chemopreventive and therapeutic potential of guggulsterone

Almazari I et al. • Topics in current chemistry (2013)

This review highlights some of the cancer chemopreventive/therapeutic targets of GS and the underlying molecular mechanisms.

Guggulsterone (GS) is a phytosterol derived from the gum resin of guggul plants that have been used traditionally to treat various disorders such as burns, wounds, gastric ulcer, cough, gum diseases, urinary complaints, diarrhea, stomach cramps, fascioliasis, and intestinal worms.
It has anti-inflammatory and antioxidative properties and has recently attracted substantial attention due to its cancer chemopreventive and therapeutic potential exemplified by its antiproliferative, antimetastatic, and proapoptotic properties in many cancer cell lines and animal models.
This review highlights some of the cancer chemopreventive/therapeutic targets of GS and the underlying molecular mechanisms.

Systematic Review

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Acute liver failure caused by 'fat burners' and dietary supplements: a case report and literature review

Yellapu RK et al. • Canadian journal of gastroenterology = Journal canadien de gastroenterologie (2011)

Until these products are more closely regulated and their advertising better scrutinized, physicians and patients should become more familiar with herbal products that are commonly used as weight loss supplements and recognize those that are potentially harmful.

The present report describes a young healthy woman who presented with fulminant hepatic failure requiring emergent liver transplantation caused by a dietary supplement and fat burner containing usnic acid, green tea and guggul tree extracts.
Thorough investigation, including histopathological examination, revealed no other cause of hepatotoxicity.
The present case adds to the increasing number of reports of hepatotoxicity associated with dietary supplements containing usnic acid, and highlights that herbal extracts from green tea or guggul tree may not be free of adverse effects.

Systematic Review

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The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review

Hasani-Ranjbar S et al. • Current pharmaceutical design (2010)

Amongst reviewed studies, 22 natural products were found effective in the treatment of hyperlipidemia that deserve further works to isolate and characterization of their constituents to reach novel therapeutic and more effective agents.

Amongst reviewed studies, 22 natural products were found effective in the treatment of hyperlipidemia that deserve further works to isolate and characterization of their constituents to reach novel therapeutic and more effective agents.
Further research warranted to confirm findings

Systematic Review

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