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5 peer-reviewed studies
What the evidence says
Most Gynostemma studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality meta-analyses and randomised trials published 2014–2025 with a typical study size of 80 participants.
Based on 5 studies · 1 meta-analysis · 3 RCTs · 196 total participants
Confidence
ModerateBy outcome
4 studies in the last 5 years · Latest meta-analysis: 2023
A 12-week randomized, double-blind, placebo-controlled trial (n=80) found a heat-processed Gynostemma extract (actiponin) reduced body weight, body fat, and BMI in obese adults.
Park SH et al. · Obesity (Silver Spring) (2014)
A small meta-analysis (15 studies) reported Gynostemma lowers triglycerides and raises HDL cholesterol; the paper is mostly preclinical (HFD mice + metabolomics).
Li Y et al. · Am J Chin Med (2023)
A small crossover RCT (n=16) found Gynostemma (450mg) improved exercise performance and altered mitochondrial markers in healthy untrained males.
Nayyar D et al. · Nutrients (2023)
A review described how Gynostemma saponins (gypenosides) regulate triglyceride and cholesterol metabolism.
Xie P et al. · J Ethnopharmacol (2024)
A 24-week randomized, double-blind, placebo-controlled trial (n=100) found a Gynostemma extract improved hair elasticity, density, and diameter.
Lee J et al. · Nutrients (2025)