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Hpr3.0

Hemp Protein Research

Mostly mechanism / observational

6 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Hemp Protein studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from high-quality randomised trials published 2018–2024 with a typical study size of 35 participants.

Based on 6 studies · 2 RCTs · 35 total participants

Confidence

Low confidence

Active research area

4 studies in the last 5 years

20182024

1RCT2021

Mollard RC, Johnston A, Serrano Leon A, Wang H, Jones PJ, MacKay DS · Appl Physiol Nutr Metab (2021)

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2Review2024

In plain English: In the final part of the chapter-for evaluating their propensity to be transported by intestinal cells-the transepithelial transport of peptides within hempseed protein hydrolysate is highlighted.

Aita SE, Montone CM, Taglioni E, Capriotti AL. · Advances in food and nutrition research (2024)

This chapter targets the nutritional and chemical composition of hempseed in terms of short- and medium-chain bioactive peptides.
The analytical approaches for their characterization and multifunctional properties are summarized in detail.
Moreover, the processing, functionality, and application of various hempseed protein products are discussed.

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3RCTn=35 · small study2024

Samsamikor M, Mackay DS, Mollard RC, Alashi AM, Aluko RE. · The American journal of clinical nutrition (2024)

Results Compared with casein, after HSP+ consumption, 24-h SBP and 24-h DBP decreased from 135.1 and 80.0 mmHg to 128.1 ± 1.6 (P < 0.0001) and 76.0 ± 1.4 mmHg (P < 0.0001), respectively, whereas these values were 133.5 ± 1.6 and 78.9 ± 1.4 mmHg after HSP consumption (P < 0.0001).
There were no differences between the HSP and HSP+ consumption in plasma angiotensin-converting enzyme (ACE) activity, renin, or nitric oxide (NO) concentrations.
However, these 2 treatments were able to lower both ACE and renin activities and raise NO concentration in plasma compared with casein.

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4In Vitro2018

In plain English: Leucine content ranged from 5.1% for hemp to 13.5% for corn protein, compared with 7.0% for egg — hemp had the lowest leucine of the proteins measured.

Gorissen SHM, Crombag JJR, Senden JMG, et al. · Amino Acids (2018)

Measured amino-acid composition of hemp and other plant vs animal protein isolates by UPLC-MS/MS
Hemp had the lowest leucine (~5.1%) of all proteins assessed, with low total essential amino acids and limiting lysine/methionine
Confirms hemp's weaker anabolic amino-acid profile vs whey, soy, and egg

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5Review2019

In plain English: Hempseed protein has good nutritional value and superior digestibility, with edestin and albumin as its main fractions and bioactive peptides of interest.

Wang Q, Xiong YL · Compr Rev Food Sci Food Saf (2019)

Review of hempseed protein chemistry, nutritional quality, and processing
Main proteins (edestin, albumin) are well digested; hemp yields bioactive peptides
Characterizes hemp as a nutritionally useful but secondary plant protein; no muscle-efficacy trials cited

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6In Vitro2022

In plain English: Hempseed meal contains ~24% essential amino acids of total amino acids, with edestin and albumin identified in the extracts.

Cabral EM, Poojary MM, Lund MN, Curtin J, Fenelon M, Tiwari BK · J Sci Food Agric (2022)

Characterized hempseed protein extraction and essential-amino-acid content
Essential amino acids made up ~24% of total amino acids — modest versus animal proteins
Confirms edestin/albumin composition and hemp's moderate essential-amino-acid quality

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View in Research Library

Hemp Protein Research

Mostly mechanism / observational

Acute effects of hemp protein consumption on glycemic and satiety control: results of 2 randomized crossover trials.

Hempseed protein-derived short- and medium-chain peptides and their multifunctional properties

Hemp seed protein and its hydrolysate compared with casein protein consumption in adults with hypertension: a double-blind crossover study

Protein content and amino acid composition of commercially available plant-based protein isolates.

Processing, Nutrition, and Functionality of Hempseed Protein: A Review.

Effect of solvent composition on the extraction of proteins from hemp oil processing stream.