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Hso2.5

Hemp Seed Oil Research

Mostly mechanism / observationalHigh safety

4 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Hemp Seed Oil studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from medium-quality randomised trials published 2005–2021.

Based on 4 studies · 2 RCTs

Confidence

Low

By outcome

Skin healthPossible reduction in skin dryness/itch in atopic dermatitis (one small crossover); not confirmed in larger trials · Weeks to a few months
Too few graded studies2 studies

Steady research

1 study in the last 5 years

200520132021

1Systematic Reviewn=596 participants across 11 RCTs · very large study2012

There is no convincing evidence of the benefit of dietary supplements in eczema, and they cannot be recommended for the public or for clinical practice at present.

Bath-Hextall FJ, Jenkinson C, Humphreys R, Williams HC · Cochrane Database Syst Rev (2012)

Cochrane review of 11 RCTs (596 participants) of dietary supplements for atopic eczema, including a hempseed oil vs placebo trial
No convincing evidence that dietary supplements as a class benefit eczema
Provides an honest counterweight to the single positive hempseed-oil crossover

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2Crossover2005

Skin dryness and itchiness improved and dermal medication usage decreased after the hempseed oil intervention.

Callaway J, Schwab U, Harvima I, Halonen P, Mykkänen O, Hyvönen P, Järvinen T · J Dermatolog Treat (2005)

20-week randomized single-blind crossover comparing dietary hempseed oil with olive oil in atopic patients
Hempseed oil raised linoleic, alpha-linolenic, and gamma-linolenic acid across lipid fractions
Skin dryness and itch improved (p=0.027) and dermal medication use fell (p=0.024); transepidermal water loss trended down (p=0.074)

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3Review2021

Hempseed oil is a source of healthy polyunsaturated fatty acids, while hempseed itself is a valuable source of essential amino acids, minerals, vitamins, and fibers.

Cerino P, Buonerba C, Cannazza G, D'Auria J, Ottoni E, Fulgione A, Di Stasio A, Pierri B, Gallo A · Cannabis Cannabinoid Res (2021)

Narrative review of hemp as food/nutritional supplement across composition and regulation
Confirms hemp SEED oil's value as a polyunsaturated-fat source and distinguishes it from cannabinoid-rich (CBD) hemp products
Notes most evidence for seed/seed-oil health claims remains preliminary

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4Crossovern=14 healthy volunteers · very large study2006

The hempseed oil period resulted in a lower total-to-HDL cholesterol ratio compared with flaxseed oil, with only minor effects on fasting serum lipid concentrations.

Schwab US, Callaway JC, Erkkilä AT, Gynther J, Uusitupa MI, Järvinen T · Eur J Nutr (2006)

Randomized double-blind crossover in 14 healthy volunteers, 30 ml/day of hempseed oil vs flaxseed oil for 4 weeks each
Hempseed oil raised serum linoleic and gamma-linolenic acid proportions
Trend toward a lower total-to-HDL cholesterol ratio (p=0.065), but no significant change in fasting total/lipoprotein lipids, glucose, insulin, or haemostatic factors

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View in Research Library

Hemp Seed Oil Research

Mostly mechanism / observational

Dietary supplements for established atopic eczema.

Efficacy of dietary hempseed oil in patients with atopic dermatitis.

A Review of Hemp as Food and Nutritional Supplement.

Effects of hempseed and flaxseed oils on the profile of serum lipids, serum total and lipoprotein lipid concentrations and haemostatic factors.