Hops Research

The Genomics of Cannabis and Its Close Relatives.

Kovalchuk I, Pellino M, Rigault P, van Velzen R, Ebersbach J, Ashnest JR · Annu Rev Plant Biol (2020)

Xanthohumol: Mechanistic Actions and Emerging Evidence as a Multi-Target Natural Nutraceutical

In plain English: Continued efforts to enhance its bioavailability and conduct rigorous clinical trials are essential to fully establish its clinical relevance in patient populations.

Azuero M, Wenceslau CF, Tan W. · Nutrients (2026)

The Promising Ability of Humulus lupulus L. Iso-α-acids vs. Diabetes, Inflammation, and Metabolic Syndrome: A Systematic Review.

Ponticelli M, Russo D, Faraone I, Sinisgalli C, Labanca F, Lela L · Molecules (2021)

Biological Activity of Hops (Humulus lupulus L.): Molecular Mechanisms and Significance for Human Health-A Review

In plain English: The development of delivery systems and consideration of the role of the gut microbiota may further increase its clinical application.

Kogut Ł et al. · Nutrients (2026)

Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: a randomized, placebo-controlled, double-blind, crossover pilot study.

Kyrou I, Christou A, Panagiotakos D, Stefanaki C, Skenderi K, Katsana K · Hormones (Athens) (2017)

A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts.

Erkkola R, Vervarcke S, Vansteelandt S, Rompotti P, De Keukeleire D, Heyerick A · Phytomedicine (2010)

A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts.

Heyerick A, Vervarcke S, Depypere H, Bracke M, De Keukeleire D · Maturitas (2006)

Effect of Humulus lupulus L. (Hop) on Postmenopausal Sexual Dysfunction: A Randomized Clinical Trial.

Vahedpoorfard Z, Ferdosi S, Rahimi H, Motedayyen H · Int J Clin Pract (2023)

The fixed combination of valerian and hops (Ze91019) acts via a central adenosine mechanism.

Schellenberg R, Sauer S, Abourashed EA, Koetter U, Brattström A · Planta Med (2004)

Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance.

Yajima H, Ikeshima E, Shiraki M, Kanaya T, Fujiwara D, Odai H · J Biol Chem (2004)

New Zealand Bitter Hops Extract Reduces Hunger During a 24 h Water Only Fast.

Walker E, Lo K, Tham S, Pahl M, Lomiwes D, Cooney J · Nutrients (2019)

A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder.

Koetter U, Schrader E, Käufeler R, Brattström A · Phytother Res (2007)

Disposition of hop prenylflavonoids in human breast tissue.

Bolca S, Li J, Nikolic D, Roche N, Blondeel P, Possemiers S · Mol Nutr Food Res (2010)

Clinical safety and efficacy of NG440: a novel combination of rho iso-alpha acids from hops, rosemary, and oleanolic acid for inflammatory conditions.

Minich DM, Bland JS, Katke J, Darland G, Hall A, Lerman RH · Can J Physiol Pharmacol (2007)

Effects of intraduodenal or intragastric administration of a bitter hop extract (Humulus lupulus L.), on upper gut motility, gut hormone secretion and energy intake in healthy-weight men.

Bitarafan V, Fitzgerald PCE, Poppitt SD, Ingram JR, Feinle-Bisset C · Appetite (2023)

The Oral Bioavailability of 8-Prenylnaringenin from Hops (Humulus Lupulus L.) in Healthy Women and Men is Significantly Higher than that of its Positional Isomer 6-Prenylnaringenin in a Randomized Crossover Trial.

Calvo-Castro LA, Burkard M, Sus N, Scheubeck G, Leischner C, Lauer UM · Mol Nutr Food Res (2018)

A Xanthohumol-Rich Hop Extract Diminishes Endotoxin-Induced Activation of TLR4 Signaling in Human Peripheral Blood Mononuclear Cells: A Study in Healthy Women.

Jung F, Staltner R, Baumann A, Burger K, Halilbasic E, Hellerbrand C · Int J Mol Sci (2022)

A dietary supplement to improve the quality of sleep: a randomized placebo controlled trial.

Cornu C, Remontet L, Noel-Baron F, Nicolas A, Feugier-Favier N, Roy P · BMC Complement Altern Med (2010)

β-Eudesmol, an Oxygenized Sesquiterpene, Reduces the Increase in Saliva 3-Methoxy-4-Hydroxyphenylglycol After the "Trier Social Stress Test" in Healthy Humans: A Randomized, Double-Blind, Placebo-Controlled Cross-Over Study.

Ohara K, Misaizu A, Kaneko Y, Fukuda T, Miyake M, Miura Y · Nutrients (2018)

An extract of hops (Humulus lupulus L.) modulates gut peptide hormone secretion and reduces energy intake in healthy-weight men: a randomized, crossover clinical trial.

Walker EG, Lo KR, Pahl MC, Shin HS, Lang C, Wohlers MW · Am J Clin Nutr (2022)