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4 peer-reviewed studies
What the evidence says
Most Horse Chestnut studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1998–2015.
Based on 4 studies · 1 meta-analysis
Confidence
ModerateNewest study from 2015 · Latest meta-analysis: 2012
A Cochrane review concluded horse chestnut seed extract is an efficacious and safe short-term treatment for chronic venous insufficiency.
Pittler MH et al. · The Cochrane database of systematic reviews (2012)
A criteria-based systematic review supported horse chestnut seed extract for chronic venous insufficiency.
Pittler MH et al. · Archives of dermatology (1998)
A systematic review of bioactive compounds in cardiovascular/venous health included horse chestnut aescin.
Pastor-Villaescusa B et al. · Annals of nutrition & metabolism (2015)
A clinical study examined aescin's effect on microcirculation in venous disease.
Luzzi R et al. · Panminerva medica (2011)