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5 peer-reviewed studies
What the evidence says
Most Humanin studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from mixed-quality studies published 2001–2018.
Based on 5 studies
Confidence
LowBy outcome
Newest study from 2018
Humanin antagonizes neurotoxicity caused by various familial Alzheimer's disease genes and amyloid-beta.
Hashimoto, Niikura, Ito, Sudo, Hata, Arakawa · The Journal of neuroscience : the official journal of the Society for Neuroscience (2001)
Humanin may link the shared pathophysiology of Alzheimer's disease and type 2 diabetes.
Mahboobi, Golmirzaei, Gan, Jalalian, Kamal · CNS & neurological disorders drug targets (2014)
Mitochondrial-derived peptides including humanin help preserve mitochondrial function and cell viability under stress.
Mendelsohn, Larrick · Rejuvenation research (2018)
A humanin analogue given before cardiac ischemia attenuated heart and brain mitochondrial dysfunction.
Kumfu, Charununtakorn, Jaiwongkam, Chattipakorn, Chattipakorn · Journal of Alzheimer's disease : JAD (2018)
Mitochondrial-derived peptides such as humanin and MOTS-c are candidate players in exceptional longevity.
Fuku, Pareja-Galeano, Zempo, Alis, Arai, Lucia · Aging cell (2015)