66 peer-reviewed studies · Evidence score: 8/10
Gupta N et al. • Journal of orthopaedic surgery and research (2025)
These findings emphasize the sustained efficacy of PRP, particularly when combined with HA, in providing superior long-term pain relief and functional improvement in knee OA compared to other intra-articular injectables, highlighting its potential as a preferred treatment modality.
Jawanda H et al. • Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association (2024)
At a minimum 6-month follow-up, PRP demonstrated significantly improved pain and function for patients with knee osteoarthritis compared with placebo.
Luo Y et al. • American journal of obstetrics and gynecology (2024)
Hyaluronic acid can safely and effectively reduce the incidence of intrauterine adhesions and may improve fertility outcomes.
Qiao X et al. • BMC musculoskeletal disorders (2023)
The current study found that PRP and PRP + HA were the most successful in improving function and alleviating pain after 3, 6, and 12 months of follow-up.
Khan M et al. • Sports health (2023)
This systematic review and meta-analysis support HA's efficacy in the treatment of a variety of soft tissue indications.
Familiari F et al. • Journal of orthopaedic research : official publication of the Orthopaedic Research Society (2023)
Journal of Orthopaedic Research®
Belk JW et al. • Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association (2023)
Patients undergoing treatment for knee OA with PRP or BMAC can be expected to experience improved clinical outcomes when compared with patients who receive HA.
Zhang J et al. • Lasers in medical science (2023)
The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
Elrosasy A et al. • Archives of dermatological research (2024)
While no significant differences were observed in efficacy among HA fillers, Giselleligne emerged as a potentially safer option for the cheeks volume restoration.
Dong Z et al. • Journal of orthopaedic surgery (Hong Kong) (2023)
Arthroscopic surgery combined with hyaluronic acid for meniscal injury can improve the efficiency of treatment compared with arthroscopic surgery alone, as well as the efficacy in relieving joint pain and improving joint function and mobility, without increasing the incidence of complications.
Bannuru RR et al. • Annals of internal medicine (2015)
This method allowed comparison of common treatments of knee OA according to their relative efficacy.
Mao B et al. • Journal of orthopaedic surgery and research (2022)
The current meta-analysis suggested that HA is a beneficial treatment procedure in improving the ROM of the shoulder for patients with FS, whereas the effect in relieving pain may be equal to the existing therapy.
Migliorini F et al. • European journal of orthopaedic surgery & traumatology : orthopedie traumatologie (2024)
The current level I evidence suggests that ozone and HA intra-articular injections achieve similar pain control between 4 and 6 months of follow-up.
Gong H et al. • Medicine (2021)
In improving knee function and quality of life, PRP showed superiority over HA in long-term follow-up from well-designed double-blind trials, but a large number of high-quality multi-center studies are still needed to provide more sufficient evidence.
Zhao J et al. • BMC musculoskeletal disorders (2020)
Compared with intra-articular injection of PRP alone, that of PRP combined with HA can improve the WOMAC Function Scores, WOMAC Total Score, 6-month follow-up VAS ratings, and Lequesne Index scores.
Xu H et al. • BMC musculoskeletal disorders (2025)
Based on the current evidence, intra-articular injection of PRP appears to be more effective than HA for the treatment of KOA, as indicated by the analysis of VAS, WOMAC scores, and other evaluation indices.
Du D et al. • Journal of orthopaedic surgery and research (2025)
This meta-analysis reveals that, for patients with KOA, PRP + HA therapy is safe and yields better outcomes in pain relief and functional improvement compared to PRP monotherapy.
Roth BJ et al. • Sexual medicine reviews (2025)
Literature on hyaluronic acid for urologic issues demonstrates promising results; however, the quality of studies was variable.
Flores-Fraile J et al. • Dental and medical problems (2025)
In individuals with TMJ pain and dysfunction, HA has shown safety and effectiveness in reducing pain and enhancing the maximum mouth opening (MMO).
Xu J et al. • Head & face medicine (2023)
PRP and PRF exhibited similar short-term efficacy in treating TMD, while PRF was more advantageous in terms of long-term efficacy.