1Systematic Review2022
Grant JK, Dangl M, Koester M, Tegegn M, Knijnik L, Singh H · J Clin Lipidol (2022)
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44 peer-reviewed studies
What the evidence says
Most Icosapent Ethyl (Vascepa) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2011–2026 with a typical study size of 13,078 participants.
Based on 44 studies · 1 meta-analysis · 41 RCTs · 21,257 total participants
Confidence
High confidenceBy outcome
25 studies in the last 5 years · Latest meta-analysis: 2022
Grant JK, Dangl M, Koester M, Tegegn M, Knijnik L, Singh H · J Clin Lipidol (2022)
Bhatt DL, Steg PG, Brinton EA, Jacobson TA, Miller M, Tardif JC · Clin Cardiol (2017)
Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, Dunbar RL · J Am Heart Assoc (2025)
Ballantyne CM, Braeckman RA, Bays HE, Kastelein JJ, Otvos JD, Stirtan WG · J Clin Lipidol (2015)
Miller M, Ballantyne CM, Bays HE, Granowitz C, Doyle RT, Juliano RA · Am J Cardiol (2019)
Ballantyne CM, Bays HE, Braeckman RA, Philip S, Stirtan WG, Doyle RT · J Clin Lipidol (2016)
Peterson BE, Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA · J Am Heart Assoc (2022)
Selvaraj S, Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA · J Am Heart Assoc (2022)
Ballantyne CM, Bays HE, Kastelein JJ, Stein E, Isaacsohn JL, Braeckman RA · Am J Cardiol (2012)
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB · N Engl J Med (2019)
Szarek M, Bhatt DL, Miller M, Brinton EA, Jacobson TA, Tardif JC · J Am Coll Cardiol (2024)
Brinton EA, Ballantyne CM, Bays HE, Kastelein JJ, Braeckman RA, Soni PN · Cardiovasc Diabetol (2013)
Weintraub WS, Bhatt DL, Zhang Z, Dolman S, Boden WE, Bress AP · J Am Heart Assoc (2024)
Miller M, Bhatt DL, Steg PG, Brinton EA, Jacobson TA, Jiao L · Eur Heart J Cardiovasc Pharmacother (2023)
Bhatt DL, Miller M, Brinton EA, Jacobson TA, Steg PG, Ketchum SB · Circulation (2020)
Miyauchi K, Iwata H, Nishizaki Y, Inoue T, Hirayama A, Kimura K · Circulation (2024)
Gaba P, Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA · J Am Coll Cardiol (2022)
Vijayaraghavan K, Szerlip HM, Ballantyne CM, Bays HE, Philip S, Doyle RT · Postgrad Med (2019)
Mosca L, Ballantyne CM, Bays HE, Guyton JR, Philip S, Doyle RT · Am J Cardiol (2017)
Verma S, Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA · Circulation (2021)