1Meta-Analysis2022
Ren S, Yao C, Liu Y, Feng G, Dong X, Gao B · Eur Neurol (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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57 peer-reviewed studies
What the evidence says
Idebenone doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality meta-analyses and randomised trials published 1992–2026.
Based on 57 studies · 6 meta-analyses · 32 RCTs
Confidence
High confidenceBy outcome
18 studies in the last 5 years · Latest meta-analysis: 2025
Ren S, Yao C, Liu Y, Feng G, Dong X, Gao B · Eur Neurol (2022)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Kearney M, Orrell RW, Fahey M, Brassington R, Pandolfo M · Cochrane Database Syst Rev (2016)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Mestre T, Ferreira J, Coelho MM, Rosa M, Sampaio C · Cochrane Database Syst Rev (2009)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Garegnani L, Hyland M, Roson Rodriguez P, Escobar Liquitay CM, Franco JV · Cochrane Database Syst Rev (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ambika S, Srilekha S · Indian J Ophthalmol (2026)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Karaarslan C · Adv Ther (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Trujillo-Martín MM, Serrano-Aguilar P, Monton-Alvarez F, Carrillo-Fumero R · Mov Disord (2009)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Vogel AP, Folker J, Poole ML · Cochrane Database Syst Rev (2014)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Yu M, Bega D · Tremor Other Hyperkinet Mov (N Y) (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Bourke JP, Bueser T, Quinlivan R · Cochrane Database Syst Rev (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: The findings of the LEROS study will help guide the clinical management of patients with LHON.
Yu-Wai-Man P, Carelli V, Newman NJ, Silva MJ, Linden A, Van Stavern G, Szaflik JP, Banik R, Lubiński W, Pemp B, Liao YJ, Subramanian PS, Misiuk-Hojło M, Newman S, Castillo L, Kocięcki J, Levin MH, Muñoz-Negrete FJ, Yagan A, Cherninkova S, Katz D, Meunier A, Votruba M, Korwin M, Dziedziak J, Jurkutė N, Harvey JP, La Morgia C, Priglinger C, Llòria X, Tomasso L, Klopstock T, LEROS Study Group. · Cell reports. Medicine (2024)
Greener J, Enderby P, Whurr R · Cochrane Database Syst Rev (2001)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: Future studies investigating oxidative stress and antioxidant therapies in FRDA should adopt a prospective, multicenter, long-term, double-blind design.
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Cárcamo-Fonfría A, Martín-Gómez MA, Agúndez JAG. · Cells (2025)
In plain English: There was no data for improvement at 2 years for idebenone, only for rAAV2-ND4. rAAV2-ND4 provides better visual acuity results at 6 months, and idebenone provides better visual acuity results at 1 year.
Hassan AK, Abu Serhan H. · Indian journal of ophthalmology (2025)
Kosa P, Wu T, Phillips J, Leinonen M, Masvekar R, Komori M · Mult Scler Relat Disord (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Drinkard BE, Keyser RE, Paul SM, Arena R, Plehn JF, Yanovski JA · Arch Phys Med Rehabil (2010)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Rudolph G, Dimitriadis K, Büchner B, Heck S, Al-Tamami J, Seidensticker F · J Neuroophthalmol (2013)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Klopstock T, Metz G, Yu-Wai-Man P, Büchner B, Gallenmüller C, Bailie M · Brain (2013)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Buyse GM, Goemans N, van den Hauwe M, Thijs D, de Groot IJ, Schara U · Neuromuscul Disord (2011)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Buyse GM, Voit T, Schara U, Straathof CSM, D'Angelo MG, Bernert G · Lancet (2015)
No plain-language summary recorded for this citation — open the paper to read its abstract.